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6JLQ
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CRYSTAL STRUCTURE OF HUMAN USP46-WDR48-WDR20 COMPLEX
Descriptor:Ubiquitin carboxyl-terminal hydrolase 46, WD repeat-containing protein 48, WD repeat-containing protein 20,highly similar to WD repeat protein 20,WD repeat-containing protein 20, ...
Authors:Zhu, H., Zhang, T., Ding, J.
Deposit date:2019-03-06
Release date:2019-07-10
Method:X-RAY DIFFRACTION (3.101 Å)
Cite:Crystal structure of human USP46-WDR48-WDR20 complex
To Be Published
6JQV
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA NRP2
Descriptor:NAP1-related protein 2
Authors:Kumar, A., Vasudevan, D.
Deposit date:2019-04-01
Release date:2019-07-10
Method:X-RAY DIFFRACTION (3.42 Å)
Cite:Structural Characterization ofArabidopsis thalianaNAP1-Related Protein 2 (AtNRP2) and Comparison with its Homolog AtNRP1.
Molecules, 24, 2019
6K1H
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STRUCTURE OF MEMBRANE PROTEIN
Descriptor:PTS system mannose-specific EIID component, PTS mannose/fructose/sorbose transporter subunit IIC, ALPHA-D-MANNOSE
Authors:Wang, J.W., Zeng, J.W.
Deposit date:2019-05-10
Release date:2019-07-10
Method:ELECTRON MICROSCOPY (3.52 Å)
Cite:Structure of the mannose transporter of the bacterial phosphotransferase system
Cell Research, 2019
6K28
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CRYSTAL STRUCTURE OF THE 5-(HYDROXYETHYL)-METHYLTHIAZOLE KINASE THIM FROM KLEBSIELLA PNEUMONIA IN COMPLEX WITH TZE
Descriptor:Hydroxyethylthiazole kinase, 2-(4-METHYL-THIAZOL-5-YL)-ETHANOL, MAGNESIUM ION
Authors:Chen, Y., Wang, L., Shang, F., Lan, J., Liu, W., Xu, Y.
Deposit date:2019-05-13
Release date:2019-07-10
Method:X-RAY DIFFRACTION (2.002 Å)
Cite:Crystal structure of the 5-(Hydroxyethyl)-methylthiazole Kinase ThiM from Klebsiella pneumonia
To Be Published
6K2K
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SOLUTION STRUCTURE OF MUL1-RING DOMAIN
Descriptor:Mitochondrial ubiquitin ligase activator of NFKB 1, ZINC ION
Authors:Lee, M.S., Lee, M.K., Ryu, K.S., Chi, S.W.
Deposit date:2019-05-14
Release date:2019-07-10
Method:SOLUTION NMR
Cite:Solution structure of MUL1-RING domain and its interaction with p53 transactivation domain.
Biochem.Biophys.Res.Commun., 2019
6K71
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EIF2 - EIF2B COMPLEX
Descriptor:Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, Translation initiation factor eIF-2B subunit gamma, ...
Authors:Kashiwagi, K., Yokoyama, T., Ito, T.
Deposit date:2019-06-05
Release date:2019-07-10
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structural basis for eIF2B inhibition in integrated stress response.
Science, 364, 2019
6K72
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EIF2(AP) - EIF2B COMPLEX
Descriptor:Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, Translation initiation factor eIF-2B subunit gamma, ...
Authors:Kashiwagi, K., Yokoyama, T., Ito, T.
Deposit date:2019-06-05
Release date:2019-07-10
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structural basis for eIF2B inhibition in integrated stress response.
Science, 364, 2019
6KBS
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CRYSTAL STRUCTURE OF YEDK IN COMPLEX WITH SSDNA
Descriptor:SOS response-associated protein, DNA (5'-D(*CP*GP*GP*TP*CP*GP*AP*TP*TP*C)-3')
Authors:Wang, N., Bao, H., Huang, H.
Deposit date:2019-06-26
Release date:2019-07-10
Method:X-RAY DIFFRACTION (1.601 Å)
Cite:Crystal structure of yedK in complex with ssDNA
To Be Published
6KBU
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CRYSTAL STRUCTURE OF YEDK
Descriptor:SOS response-associated protein, GLYCEROL
Authors:Wang, N., Bao, H., Huang, H.
Deposit date:2019-06-26
Release date:2019-07-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of yedK
To Be Published
6KBX
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CRYSTAL STRUCTURE OF YEDK IN COMPLEX WITH SSDNA CONTAINING ABASIC SITE
Descriptor:SOS response-associated protein, DNA 5'-D (*CP*GP*GP*TP* (PED)P*GP*AP*TP*TP*C)-3'
Authors:Wang, N., Bao, H., Huang, H.
Deposit date:2019-06-26
Release date:2019-07-10
Method:X-RAY DIFFRACTION (1.221 Å)
Cite:Crystal structure of yedK in complex with ssDNA containing abasic site
To Be Published
6KBZ
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CRYSTAL STRUCTURE OF YEDK WITH SSDNA CONTAINING A TETRAHYDROFURAN ABASIC SITE
Descriptor:SOS response-associated protein, 5'-D (*CP*GP*GP*TP* (3DR) P*GP*AP*TP*TP*C)-3', MAGNESIUM ION
Authors:Wang, N., Bao, H., Huang, H.
Deposit date:2019-06-26
Release date:2019-07-10
Method:X-RAY DIFFRACTION (1.653 Å)
Cite:Crystal structure of yedK
To Be Published
6KCQ
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CRYSTAL STRUCTURE OF YEDK WITH SSDNA CONTAINING AN ABASIC SITE
Descriptor:SOS response-associated protein, DNA (5'-D(P*AP*AP*AP*(PED)P*AP*A)-3')
Authors:Wang, N., Bao, H., Huang, H.
Deposit date:2019-06-28
Release date:2019-07-10
Method:X-RAY DIFFRACTION (1.701 Å)
Cite:Crystal structure of yedK
To Be Published
6MCW
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CRYSTAL STRUCTURE OF THE P450 DOMAIN OF THE CYP51-FERREDOXIN FUSION PROTEIN FROM METHYLOCOCCUS CAPSULATUS, COMPLEX WITH THE DETERGENT ANAPOE-X-114
Descriptor:Cytochrome P450 51, 23-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]-3,6,9,12,15,18,21-heptaoxatricosan-1-ol, PROTOPORPHYRIN IX CONTAINING FE
Authors:Hargrove, T., Wawrzak, Z., Lamb, D.C., Lepesheva, G.I.
Deposit date:2018-09-02
Release date:2019-07-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the P450 domain of the CYP51-ferredoxin fusion protein from Methylococcus capsulatus, complex with the detergent Anapoe-X-114
To Be Published
6MI0
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CRYSTAL STRUCTURE OF THE P450 DOMAIN OF THE CYP51-FERREDOXIN FUSION PROTEIN FROM METHYLOCOCCUS CAPSULATUS, LIGAND-FREE STATE
Descriptor:Cytochrome P450 51, PROTOPORPHYRIN IX CONTAINING FE
Authors:Hargrove, T., Wawrzak, Z., Lamb, D.C., Lepesheva, G.I.
Deposit date:2018-09-18
Release date:2019-07-10
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:Crystal structure of the P450 domain of the CYP51-ferredoxin fusion protein from Methylococcus capsulatus
To Be Published
6N0J
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THE COMPLEX OF CCG-222740 BOUND TO PIRIN
Descriptor:Pirin, FE (III) ION, (3S)-N-(4-chlorophenyl)-5,5-difluoro-1-[3-(furan-2-yl)benzene-1-carbonyl]piperidine-3-carboxamide, ...
Authors:Lisabeth, E.M., Jin, X., Neubig, R.
Deposit date:2018-11-07
Release date:2019-07-10
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Identification of Pirin as a Molecular Target of the CCG-1423/CCG-203971 Series of Antifibrotic and Antimetastatic Compounds
ACS Pharmacol Transl Sci, 2, 2019
6N0K
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THE COMPLEX OF CCG-257081 BOUND TO PIRIN
Descriptor:Pirin, FE (III) ION, (3R)-N-(4-chlorophenyl)-5,5-difluoro-1-[3-fluoro-5-(pyridin-4-yl)benzene-1-carbonyl]piperidine-3-carboxamide, ...
Authors:Lisabeth, E.M., Jin, X., Neubig, R.
Deposit date:2018-11-07
Release date:2019-07-10
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Identification of Pirin as a Molecular Target of the CCG-1423/CCG-203971 Series of Antifibrotic and Antimetastatic Compounds
ACS Pharmacol Transl Sci, 2, 2019
6N2I
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LON PROTEASE AAA+ DOMAIN
Descriptor:DNA-binding ATP-dependent protease La, ADENOSINE-5'-DIPHOSPHATE
Authors:Botos, I., Li, M., Wlodawer, A., Gustchina, A.
Deposit date:2018-11-13
Release date:2019-07-10
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:New insights into structural and functional relationships between LonA proteases and ClpB chaperones.
Febs Open Bio, 2019
6N84
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MBP-FUSION PROTEIN OF TRANSDUCIN-ALPHA RESIDUES 327-350
Descriptor:G alpha t C terminal fragment fused to maltose binding protein, MALTOSE, SULFATE ION
Authors:Srivastava, D., Gakhar, L., Artemyev, N.O.
Deposit date:2018-11-28
Release date:2019-07-10
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural underpinnings of Ric8A function as a G-protein alpha-subunit chaperone and guanine-nucleotide exchange factor
Nat Commun, 2019
6N85
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RESISTANCE TO INHIBITORS OF CHOLINESTERASE 8A (RIC8A) PROTEIN IN COMPLEX WITH MBP-TAGGED TRANSDUCIN-ALPHA RESIDUES 327-350
Descriptor:Synembryn-A, G alpha t C terminal fragment fused to maltose binding protein, MALTOSE
Authors:Srivastava, D., Gakhar, L., Artemyev, N.O.
Deposit date:2018-11-28
Release date:2019-07-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural underpinnings of Ric8A function as a G-protein alpha-subunit chaperone and guanine-nucleotide exchange factor
Nat Commun, 2019
6N86
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RESISTANCE TO INHIBITORS OF CHOLINESTERASE 8A (RIC8A) PROTEIN
Descriptor:Synembryn-A
Authors:Srivastava, D., Gakhar, L., Artemyev, N.O.
Deposit date:2018-11-28
Release date:2019-07-10
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Structural underpinnings of Ric8A function as a G-protein alpha-subunit chaperone and guanine-nucleotide exchange factor
Nat Commun, 2019
6NJY
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TYPE IV CRISPR ASSOCIATED RNA ENDONUCLEASE CAS6 - APO FORM
Descriptor:Type IV CRISPR associated Cas6 RNA endonuclease, SULFATE ION, BETA-D-GLUCOSE
Authors:Jackson, R.N., Warner, E., Olsen, K.J.
Deposit date:2019-01-04
Release date:2019-07-10
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structural basis of Type IV CRISPR RNA biogenesis by a Cas6 endoribonuclease.
Rna Biol., 2019
6NNG
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TUBULIN-RB3_SLD-TTL IN COMPLEX WITH COMPOUND DJ95
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Kumar, G., Wang, Y., Li, W., White, S.W.
Deposit date:2019-01-15
Release date:2019-07-10
Method:X-RAY DIFFRACTION (2.397 Å)
Cite:Colchicine Binding Site Agent DJ95 Overcomes Drug Resistance and Exhibits Antitumor Efficacy.
Mol.Pharmacol., 96, 2019
6NT2
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TYPE 1 PRMT IN COMPLEX WITH THE INHIBITOR GSK3368715
Descriptor:Protein arginine N-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, N~1~-({5-[4,4-bis(ethoxymethyl)cyclohexyl]-1H-pyrazol-4-yl}methyl)-N~1~,N~2~-dimethylethane-1,2-diamine, ...
Authors:Concha, N.O.
Deposit date:2019-01-28
Release date:2019-07-10
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss
Cancer Cell, 2019
6NVG
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FGFR4 COMPLEX WITH N-(3,5-DICHLORO-2-((5-((2,6-DICHLORO-3,5-DIMETHOXYBENZYL)OXY)PYRIMIDIN-2-YL)AMINO)PHENYL)ACRYLAMIDE
Descriptor:Fibroblast growth factor receptor 4, SULFATE ION, N-[3,5-dichloro-2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)phenyl]propanamide
Authors:Lin, X., Smaill, J.B., Squire, C.J., Yosaatmadja, Y.
Deposit date:2019-02-05
Release date:2019-07-10
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Rotational freedom, steric hindrance and protein dynamics explain BLU554 selectivity for the hinge cysteine of FGFR4
Acs Med.Chem.Lett., 2019
6NVH
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FGFR4 COMPLEX WITH N-(2-((5-((2,6-DICHLORO-3,5-DIMETHOXYBENZYL)OXY)PYRIMIDIN-2-YL)AMINO)-3-METHYLPHENYL)ACRYLAMIDE
Descriptor:Fibroblast growth factor receptor 4, SULFATE ION, N-[2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)-3-methylphenyl]propanamide
Authors:Lin, X., Smaill, J.B., Squire, C.J.
Deposit date:2019-02-05
Release date:2019-07-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Rotational freedom, steric hindrance and protein dynamics explain BLU554 selectivity for the hinge cysteine of FGFR4
Acs Med.Chem.Lett., 2019