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6MYU
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AVIAN MITOCHONDRIAL COMPLEX II CRYSTALLIZED IN THE PRESENCE OF HQNO
Descriptor:Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial, Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, ...
Authors:Berry, E.A., Huang, L.-S.
Deposit date:2018-11-02
Release date:2019-11-06
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Crystallographic studies of the binding of ligands to the Ubiquinone site of Mitochondrial Respiratory Complex II
To be published
6MYZ
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CRYSTAL STRUCTURE OF TDP1 CATALYTIC DOMAIN IN COMPLEX WITH COMPOUND XZ520
Descriptor:Tyrosyl-DNA phosphodiesterase 1, 4-oxo-8-phenyl-1,4-dihydroquinoline-3-carboxylic acid, 1,2-ETHANEDIOL
Authors:Lountos, G.T., Zhao, X.Z., Kiselev, E., Tropea, J.E., Needle, D., Burke Jr., T.R., Pommier, Y., Waugh, D.S.
Deposit date:2018-11-02
Release date:2019-11-06
Method:X-RAY DIFFRACTION (1.661 Å)
Cite:Structure of Tdp1 catalytic domain in complex with compound XZ520
To Be Published
6MZ0
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CRYSTAL STRUCTURE OF TDP1 CATALYTIC DOMAIN IN COMPLEX WITH COMPOUND XZ530
Descriptor:Tyrosyl-DNA phosphodiesterase 1, 5-hydroxypyrazine-2,3-dicarboxylic acid, 1,2-ETHANEDIOL
Authors:Lountos, G.T., Zhao, X.Z., Kiselev, E., Tropea, J.E., Needle, D., Burke Jr., T.R., Pommier, Y., Waugh, D.S.
Deposit date:2018-11-02
Release date:2019-11-06
Method:X-RAY DIFFRACTION (1.969 Å)
Cite:Structure of Tdp1 catalytic domain in complex with compound XZ530
To Be Published
6N7Y
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CRYSTAL STRUCTURE OF HUMAN FPPS IN COMPLEX WITH AN ALLOSTERIC INHIBITOR MIT-01-102
Descriptor:Farnesyl pyrophosphate synthase, GLYCEROL, [(1R)-1-{[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}-2-phenylethyl]phosphonic acid, ...
Authors:Park, J., Berghuis, A.M.
Deposit date:2018-11-28
Release date:2019-11-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Chirality-Driven Mode of Binding of alpha-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS).
J.Med.Chem., 2019
6N7Z
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CRYSTAL STRUCTURE OF HUMAN FPPS IN COMPLEX WITH AN ALLOSTERIC INHIBITOR YF-02037
Descriptor:Farnesyl pyrophosphate synthase, GLYCEROL, [(1S)-1-{[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}-2-phenylethyl]phosphonic acid, ...
Authors:Park, J., Berghuis, A.M.
Deposit date:2018-11-28
Release date:2019-11-06
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Chirality-Driven Mode of Binding of alpha-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS).
J.Med.Chem., 2019
6N82
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CRYSTAL STRUCTURE OF HUMAN FPPS IN COMPLEX WITH AN ALLOSTERIC INHIBITOR YF-02037
Descriptor:Farnesyl pyrophosphate synthase, GLYCEROL, [(1S)-1-{[6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}-2-(3-fluorophenyl)ethyl]phosphonic acid, ...
Authors:Park, J., Schilling, M.A., Berghuis, A.M.
Deposit date:2018-11-28
Release date:2019-11-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Chirality-Driven Mode of Binding of alpha-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS).
J.Med.Chem., 2019
6N83
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CRYSTAL STRUCTURE OF HUMAN FPPS IN COMPLEX WITH AN ALLOSTERIC INHIBITOR YF-02037
Descriptor:Farnesyl pyrophosphate synthase, [(1R)-1-{[6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}-2-(3-fluorophenyl)ethyl]phosphonic acid, PHOSPHATE ION, ...
Authors:Park, J., Schilling, M.A., Berghuis, A.M.
Deposit date:2018-11-28
Release date:2019-11-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Chirality-Driven Mode of Binding of alpha-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS).
J.Med.Chem., 2019
6N90
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YOEB/PARE TOXIN FROM AGROBACTERIUM TUMEFACIENS
Descriptor:Uncharacterized protein, 6-tungstotellurate(VI)
Authors:Bourne, C.R., Reddem, E.R.
Deposit date:2018-11-30
Release date:2019-11-06
Method:X-RAY DIFFRACTION (1.755 Å)
Cite:YoeB/ParE toxin from Agrobacterium tumefaciens
Biorxiv, 2019
6NF5
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BG505 MD64 N332-GT5 SOSIP TRIMER IN COMPLEX WITH BG18-LIKE PRECURSOR HMP1 FRAGMENTANTIGEN BINDING AND BASE-BINDING RM20A3 FRAGMENT ANTIGEN BINDING
Descriptor:HIV-1 Env BG505 MD64 N332-GT5 SOSIP gp120, HIV-1 Env BG505 MD64 N332-GT5 SOSIP gp41, BG18-like precursor HMP1 fragment antigen binding heavy chain, ...
Authors:Ozorowski, G., Torres, J.L., Steichen, J.M., Schief, W.R., Ward, A.B.
Deposit date:2018-12-18
Release date:2019-11-06
Last modified:2019-11-13
Method:ELECTRON MICROSCOPY (3.71 Å)
Cite:A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses.
Science, 2019
6NFC
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BG505 MD64 N332-GT5 SOSIP TRIMER IN COMPLEX WITH BG18-LIKE PRECURSOR HMP42 FRAGMENTANTIGEN BINDING AND BASE-BINDING RM20A3 FRAGMENT ANTIGEN BINDING
Descriptor:base-binding RM20A3 fragment antigen binding heavy chain, base-binding RM20A3 fragment antigen binding light chain, HIV-1 Env BG505 MD64 N332-GT5 SOSIP gp120, ...
Authors:Ozorowski, G., Torres, J.L., Ward, A.B.
Deposit date:2018-12-19
Release date:2019-11-06
Last modified:2019-11-13
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses.
Science, 2019
6NFW
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POTYVIRUS VIRAL PROTEIN GENOME LINKED (VPG) EMULATES THE M7G CAP TO RECRUIT THE EUKARYOTIC TRANSLATION INITIATION FACTOR EIF4E
Descriptor:VPg
Authors:Borden, K., Volpon, L., Osborne, M.
Deposit date:2018-12-21
Release date:2019-11-06
Last modified:2019-11-13
Method:SOLUTION NMR
Cite:Structural studies of the eIF4E-VPg complex reveal a direct competition for capped RNA: implications for translation
Proc.Natl.Acad.Sci.USA, 2019
6NL1
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STRUCTURE OF T. BRUCEI MERS1 PROTEIN IN ITS APO FORM
Descriptor:Mitochondrial edited mRNA stability factor 1, SULFATE ION
Authors:Schumacher, M.A.
Deposit date:2019-01-07
Release date:2019-11-06
Method:X-RAY DIFFRACTION (2.297 Å)
Cite:Structures of MERS1, the 5' processing enzyme of mitochondrial mRNAs in Trypanosoma brucei
Rna, 2019
6NWC
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PYL10 BOUND TO THE ABA PAN-AGONIST 3CB
Descriptor:Abscisic acid receptor PYL10, 1-{[(4-cyano-3-cyclopropylphenyl)acetyl]amino}cyclohexane-1-carboxylic acid
Authors:Peterson, F.C., Vaidya, A., Jensen, D.R., Volkman, B.F., Cutler, S.R.
Deposit date:2019-02-06
Release date:2019-11-06
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Dynamic control of plant water use using designed ABA receptor agonists.
Science, 366, 2019
6NZD
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CRYO-EM STRUCTURE OF THE LYSOSOMAL FOLLICULIN COMPLEX (FLCN-FNIP2-RAGA-RAGC-RAGULATOR)
Descriptor:Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ...
Authors:Fromm, S.A., Young, L.N., Hurley, J.H.
Deposit date:2019-02-13
Release date:2019-11-06
Last modified:2019-11-13
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex.
Science, 2019
6O4I
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STRUCTURE OF ALDH7A1 MUTANT E399D COMPLEXED WITH ALPHA-AMINOADIPATE
Descriptor:Alpha-aminoadipic semialdehyde dehydrogenase, 2-AMINOHEXANEDIOIC ACID, 1,2-ETHANEDIOL
Authors:Tanner, J.J., Korasick, D.A., Laciak, A.R.
Deposit date:2019-02-28
Release date:2019-11-06
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural Analysis of Pathogenic Mutations Targeting Glu427 of ALDH7A1, the Hot Spot Residue of Pyridoxine-Dependent Epilepsy.
J. Inherit. Metab. Dis., 2019
6O4K
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STRUCTURE OF ALDH7A1 MUTANT E399Q COMPLEXED WITH NAD
Descriptor:Alpha-aminoadipic semialdehyde dehydrogenase, 1,2-ETHANEDIOL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Tanner, J.J., Korasick, D.A., Laciak, A.R.
Deposit date:2019-02-28
Release date:2019-11-06
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structural Analysis of Pathogenic Mutations Targeting Glu427 of ALDH7A1, the Hot Spot Residue of Pyridoxine-Dependent Epilepsy.
J. Inherit. Metab. Dis., 2019
6O4L
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STRUCTURE OF ALDH7A1 MUTANT E399D COMPLEXED WITH NAD
Descriptor:Alpha-aminoadipic semialdehyde dehydrogenase, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Tanner, J.J., Korasick, D.A., Laciak, A.R.
Deposit date:2019-02-28
Release date:2019-11-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Analysis of Pathogenic Mutations Targeting Glu427 of ALDH7A1, the Hot Spot Residue of Pyridoxine-Dependent Epilepsy.
J. Inherit. Metab. Dis., 2019
6O67
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CRYSTAL STRUCTURE OF HUMAN PPARGAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH MITOGLITAZONE
Descriptor:Peroxisome proliferator-activated receptor gamma, Mitoglitazone, nonanoic acid
Authors:Shang, J., Kojetin, D.J.
Deposit date:2019-03-05
Release date:2019-11-06
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Quantitative structural assessment of graded receptor agonism.
Proc.Natl.Acad.Sci.USA, 116, 2019
6O68
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CRYSTAL STRUCTURE OF HUMAN PPARGAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH CIGLITAZONE
Descriptor:Peroxisome proliferator-activated receptor gamma, Ciglitazone
Authors:Shang, J., Kojetin, D.J.
Deposit date:2019-03-05
Release date:2019-11-06
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Quantitative structural assessment of graded receptor agonism.
Proc.Natl.Acad.Sci.USA, 116, 2019
6OAG
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CRYSTAL STRUCTURE OF HUMAN FPPS IN COMPLEX WITH AN ALLOSTERIC INHIBITOR YF-02-82
Descriptor:Farnesyl pyrophosphate synthase, [(1S)-1-{[6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}-2-phenylethyl]phosphonic acid, PHOSPHATE ION
Authors:Park, J., Berghuis, A.M.
Deposit date:2019-03-16
Release date:2019-11-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Chirality-Driven Mode of Binding of alpha-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS).
J.Med.Chem., 2019
6OAH
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CRYSTAL STRUCTURE OF HUMAN FPPS IN COMPLEX WITH AN ALLOSTERIC INHIBITOR YF-02-78
Descriptor:Farnesyl pyrophosphate synthase, GLYCEROL, [(1R)-1-{[6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}-2-phenylethyl]phosphonic acid, ...
Authors:Park, J., Berghuis, A.M.
Deposit date:2019-03-16
Release date:2019-11-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Chirality-Driven Mode of Binding of alpha-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS).
J.Med.Chem., 2019
6OIM
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CRYSTAL STRUCTURE OF HUMAN KRAS G12C COVALENTLY BOUND TO AMG 510
Descriptor:GTPase KRas, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Mohr, C.
Deposit date:2019-04-09
Release date:2019-11-06
Last modified:2019-11-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity.
Nature, 2019
6OTT
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STRUCTURE OF PURF IN COMPLEX WITH PPAPP
Descriptor:Amidophosphoribosyltransferase, PurF, MAGNESIUM ION, ...
Authors:Grant, R.A., Wang, B., Laub, M.T.
Deposit date:2019-05-03
Release date:2019-11-06
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:An interbacterial toxin inhibits target cell growth by synthesizing (p)ppApp
Nature, 2019
6OY3
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NHTMEM16 L302A +CA2+ IN NANODISCS
Descriptor:nhTMEM16, CALCIUM ION
Authors:Falzone, M., Lee, B.C., Accardi, A.
Deposit date:2019-05-14
Release date:2019-11-06
Method:ELECTRON MICROSCOPY (4 Å)
Cite:nhTMEM16 L302A +Ca2+ in nanodiscs
To Be Published
6P5R
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STRUCTURE OF T. BRUCEI MERS1-GDP COMPLEX
Descriptor:Mitochondrial edited mRNA stability factor 1, GUANOSINE-5'-DIPHOSPHATE
Authors:Schumacher, M.A.
Deposit date:2019-05-30
Release date:2019-11-06
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structures of MERS1, the 5' processing enzyme of mitochondrial mRNAs in Trypanosoma brucei
Rna, 2019