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6KO8
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CRYSTAL STRUCTURE OF THE CHOLIC ACID BOUND RAMR DETERMINED WITH XTALAB SYNERGY
Descriptor:Putative regulatory protein, CHOLIC ACID, SULFATE ION
Authors:Matsumoto, T., Nakashima, R., Yamano, A., Nishino, K.
Deposit date:2019-08-08
Release date:2019-10-09
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Development of a structure determination method using a multidrug-resistance regulator protein as a framework.
Biochem.Biophys.Res.Commun., 518, 2019
6KO9
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CRYSTAL STRUCTURE OF THE GEFITINIB INTERMEDIATE 1 BOUND RAMR DETERMINED WITH XTALAB SYNERGY
Descriptor:Putative regulatory protein, 4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-7-methoxy-quinazolin-6-ol, SULFATE ION
Authors:Matsumoto, T., Nakashima, R., Yamano, A., Nishino, K.
Deposit date:2019-08-08
Release date:2019-10-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Development of a structure determination method using a multidrug-resistance regulator protein as a framework.
Biochem.Biophys.Res.Commun., 518, 2019
6Q2J
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CRYO-EM STRUCTURE OF EXTRACELLULAR DIMERIC COMPLEX OF RET/GFRAL/GDF15
Descriptor:Growth/differentiation factor 15, GDNF family receptor alpha-like, Proto-oncogene tyrosine-protein kinase receptor Ret, ...
Authors:Li, J., Shang, G.J., Chen, Y.J., Brautigam, C.A., Liou, J., Zhang, X.W., Bai, X.C.
Deposit date:2019-08-08
Release date:2019-10-02
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands.
Elife, 8, 2019
6Q2M
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CRYSTAL STRUCTURE OF PHOTINUS PYRALIS LUCIFERASE PPS6 MUTANT IN COMPLEX WITH DLSA
Descriptor:Luciferin 4-monooxygenase, SULFATE ION, (2S,5S)-hexane-2,5-diol, ...
Authors:Patel, K.D., Gulick, A.M.
Deposit date:2019-08-08
Release date:2019-10-16
Last modified:2019-11-06
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Mutagenesis and Structural Studies Reveal the Basis for the Activity and Stability Properties That Distinguish thePhotinusLuciferasesscintillansandpyralis.
Biochemistry, 58, 2019
6Q2N
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CRYO-EM STRUCTURE OF RET/GFRA1/GDNF EXTRACELLULAR COMPLEX
Descriptor:Glial cell line-derived neurotrophic factor, GDNF family receptor alpha-1, Proto-oncogene tyrosine-protein kinase receptor Ret, ...
Authors:Li, J., Shang, G.J., Chen, Y.J., Brautigam, C.A., Liou, J., Zhang, X.W., Bai, X.C.
Deposit date:2019-08-08
Release date:2019-10-02
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands.
Elife, 8, 2019
6Q2O
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CRYO-EM STRUCTURE OF RET/GFRA2/NRTN EXTRACELLULAR COMPLEX. THE 3D REFINEMENT WAS APPLIED WITH C2 SYMMETRY.
Descriptor:Neurturin, GDNF family receptor alpha-2, Proto-oncogene tyrosine-protein kinase receptor Ret, ...
Authors:Li, J., Shang, G.J., Chen, Y.J., Brautigam, C.A., Liou, J., Zhang, X.W., Bai, X.C.
Deposit date:2019-08-08
Release date:2019-10-02
Method:ELECTRON MICROSCOPY (3.65 Å)
Cite:Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands.
Elife, 8, 2019
6Q2R
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CRYO-EM STRUCTURE OF RET/GFRA2/NRTN EXTRACELLULAR COMPLEX IN THE TETRAMERIC FORM
Descriptor:Neurturin, GDNF family receptor alpha-2, Proto-oncogene tyrosine-protein kinase receptor Ret, ...
Authors:Li, J., Shang, G.J., Chen, Y.J., Brautigam, C.A., Liou, J., Zhang, X.W., Bai, X.C.
Deposit date:2019-08-08
Release date:2019-10-02
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands.
Elife, 8, 2019
6Q2S
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CRYO-EM STRUCTURE OF RET/GFRA3/ARTN EXTRACELLULAR COMPLEX. THE 3D REFINEMENT WAS APPLIED WITH C2 SYMMETRY.
Descriptor:Ubiquitin-like protein SMT3,Artemin, GDNF family receptor alpha-3, Proto-oncogene tyrosine-protein kinase receptor Ret, ...
Authors:Li, J., Shang, G.J., Chen, Y.J., Brautigam, C.A., Liou, J., Zhang, X.W., Bai, X.C.
Deposit date:2019-08-08
Release date:2019-10-02
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands.
Elife, 8, 2019
6Q2T
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HUMAN STEROL 14A-DEMETHYLASE (CYP51) IN COMPLEX WITH THE FUNCTIONALLY IRREVERSIBLE INHIBITOR (R)-N-(1-(3-CHLORO-4'-FLUORO-[1,1'-BIPHENYL]-4-YL)-2-(1H-IMIDAZOL-1-YL)ETHYL)-4-(5-(3-FLUORO-5-(5-FLUOROPYRIMIDIN-4-YL)PHENYL)-1,3,4-OXADIAZOL-2-YL)BENZAMIDE
Descriptor:Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, N-[(1R)-1-(3-chloro-4'-fluoro[1,1'-biphenyl]-4-yl)-2-(1H-imidazol-1-yl)ethyl]-4-{5-[3-fluoro-5-(5-fluoropyrimidin-4-yl)phenyl]-1,3,4-oxadiazol-2-yl}benzamide, ...
Authors:Friggeri, L., Hargrove, T.Y., Wawrzak, Z., Lepesheva, G.I.
Deposit date:2019-08-08
Release date:2019-11-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Validation of human sterol 14 alpha-demethylase (CYP51) druggability: structure-guided design, synthesis and evaluation of stoichiometric, functionally irreversible inhibitors.
J.Med.Chem., 2019
6SHS
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ABETA FIBRIL (MORPHOLOGY I)
Descriptor:Amyloid-beta precursor protein
Authors:Kollmer, M., Fandrich, M.
Deposit date:2019-08-08
Release date:2019-11-06
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Cryo-EM structure and polymorphism of A beta amyloid fibrils purified from Alzheimer's brain tissue.
Nat Commun, 10, 2019
6TYA
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STRUCTURE OF N-TERMINUS LOCKED ESP WITH ONE PRO-PEPTIDE RESIDUE - V67C, D255C
Descriptor:Glutamyl endopeptidase
Authors:Manne, K., Narayana, S.V.L.
Deposit date:2019-08-08
Release date:2019-08-28
Method:X-RAY DIFFRACTION (2.065943 Å)
Cite:Structural Insights into the Role of N-Terminus in the Activation and Function of Extracellular Serine Protease of Staphylococcus epidermidis
To Be Published
6TYB
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ISOLATION AND STRUCTURE OF AN ANTIBODY THAT FULLY NEUTRALIZES ISOLATE SIVMAC239 REVEALS FUNCTIONAL SIMILARITY OF SIV AND HIV GLYCAN SHIELDS
Descriptor:Envelope glycoprotein gp160, T-cell surface glycoprotein CD4, NEUTRALIZING ANTIBODY ITS90.03 FAB HEAVY CHAIN, ...
Authors:Gorman, J., Kwong, P.D.
Deposit date:2019-08-08
Release date:2019-10-02
Last modified:2019-10-30
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Isolation and Structure of an Antibody that Fully Neutralizes Isolate SIVmac239 Reveals Functional Similarity of SIV and HIV Glycan Shields.
Immunity, 51, 2019
6TYH
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FOUR-DISULFIDE INSULIN ANALOG A22/B22
Descriptor:Insulin A chain, Insulin B chain, PHENOL, ...
Authors:Blakely, A.D., Xiong, X.
Deposit date:2019-08-08
Release date:2019-11-13
Method:X-RAY DIFFRACTION (1.600019 Å)
Cite:Novel Four-Disulfide Insulin Analog with High Aggregation Stability and Potency
Chem Sci, 2019
6KNS
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CRYSTAL STRUCTURE OF THE METALLO-BETA-LACTAMASE FOLD PROTEIN YHFI FROM BACILLUS SUBTILIS (SPACE GROUP I4122)
Descriptor:Putative metal-dependent hydrolase, CALCIUM ION, ZINC ION
Authors:Na, H.W., Namgung, B., Song, W.S., Yoon, S.I.
Deposit date:2019-08-07
Release date:2019-09-18
Last modified:2019-10-09
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural and biochemical analyses of the metallo-beta-lactamase fold protein YhfI from Bacillus subtilis.
Biochem.Biophys.Res.Commun., 519, 2019
6KNT
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CRYSTAL STRUCTURE OF THE METALLO-BETA-LACTAMASE FOLD PROTEIN YHFI FROM BACILLUS SUBTILIS (SPACE GROUP P4332)
Descriptor:Putative metal-dependent hydrolase, ZINC ION
Authors:Na, H.W., Namgung, B., Song, W.S., Yoon, S.I.
Deposit date:2019-08-07
Release date:2019-09-18
Last modified:2019-10-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and biochemical analyses of the metallo-beta-lactamase fold protein YhfI from Bacillus subtilis.
Biochem.Biophys.Res.Commun., 519, 2019
6KNU
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THRB MUTATION WITH A NOVEL AGONIST
Descriptor:Thyroid hormone receptor beta, Nuclear receptor coactivator 2, 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid
Authors:Yao, B.Q., Li, Y.
Deposit date:2019-08-07
Release date:2019-10-23
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A novel agonist of THRb
To Be Published
6KNV
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THRB MUTATION WITH A NOVEL AGONIST
Descriptor:Thyroid hormone receptor beta, Nuclear receptor coactivator 2, 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid
Authors:Yao, B.Q., Li, Y.
Deposit date:2019-08-07
Release date:2019-10-23
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A novel agonist of THRb
To Be Published
6KNW
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THRB MUTATION WITH A NOVEL AGONIST
Descriptor:Thyroid hormone receptor beta, Nuclear receptor coactivator 2, 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid
Authors:Yao, B.Q., Li, Y.
Deposit date:2019-08-07
Release date:2019-10-23
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:A novel agonist of THRb
To Be Published
6KNZ
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CRYSTAL STRUCTURE OF T2R-TTL-KXO1 COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Chen, Q., Yu, Y.
Deposit date:2019-08-07
Release date:2019-10-23
Last modified:2019-10-30
Method:X-RAY DIFFRACTION (2.475 Å)
Cite:Reversible binding of the anticancer drug KXO1 (tirbanibulin) to the colchicine-binding site of beta-tubulin explains KXO1's low clinical toxicity.
J.Biol.Chem., 2019
6Q2B
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CRYSTAL STRUCTURE OF PUTATIVE MARR FAMILY TRANSCRIPTIONAL REGULATOR FROM LISTERIA MONOCYTOGENES COMPLEXED WITH 26MER DNA
Descriptor:MarR family transcriptional regulator, DNA (26-MER), ACETIC ACID
Authors:Kim, Y., Tesar, C., Clancy, S., Joachimiak, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2019-08-07
Release date:2019-08-21
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Crystal Structure of Putative MarR Family Transcriptional Regulator from Listeria monocytogenes complexed with 26mer DNA.
To Be Published
6Q2D
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CRYSTAL STRUCTURE OF METHANOBREVIBACTER SMITHII DPH2 IN COMPLEX WITH METHANOBREVIBACTER SMITHII ELONGATION FACTOR 2
Descriptor:2-(3-amino-3-carboxypropyl)histidine synthase, Elongation factor 2, IRON/SULFUR CLUSTER
Authors:Fenwick, M.K., Dong, M., Lin, H., Ealick, S.E.
Deposit date:2019-08-07
Release date:2019-10-16
Last modified:2019-11-13
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:The Crystal Structure of Dph2 in Complex with Elongation Factor 2 Reveals the Structural Basis for the First Step of Diphthamide Biosynthesis.
Biochemistry, 58, 2019
6Q2E
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CRYSTAL STRUCTURE OF METHANOBREVIBACTER SMITHII DPH2 BOUND TO 5'-METHYLTHIOADENOSINE
Descriptor:2-(3-amino-3-carboxypropyl)histidine synthase, 5'-DEOXY-5'-METHYLTHIOADENOSINE, IRON/SULFUR CLUSTER, ...
Authors:Fenwick, M.K., Dong, M., Lin, H., Ealick, S.E.
Deposit date:2019-08-07
Release date:2019-10-16
Last modified:2019-11-13
Method:X-RAY DIFFRACTION (1.768 Å)
Cite:The Crystal Structure of Dph2 in Complex with Elongation Factor 2 Reveals the Structural Basis for the First Step of Diphthamide Biosynthesis.
Biochemistry, 58, 2019
6SHK
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HIGH RESOLUTION STRUCTURE OF THE ANTIMICROBIAL PEPTIDE DERMCIDIN FROM HUMAN
Descriptor:Dermcidin, ZINC ION
Authors:Zeth, K.
Deposit date:2019-08-07
Release date:2019-09-25
Method:X-RAY DIFFRACTION (1.992 Å)
Cite:Crystal Structure and Functional Mechanism of a Human Antimicrobial Membrane Channel
To be published
6SHO
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SAD STRUCTURE OF HUMAN SURVIVIN RECOVERED BY CONTINUOUS ROTATION DATA COLLECTION AND MULTIVARIATE ANALYSIS OF FRIEDEL PAIRS
Descriptor:Baculoviral IAP repeat-containing protein 5, ZINC ION
Authors:Garcia-Bonete, M.J., Katona, G.
Deposit date:2019-08-07
Release date:2019-11-06
Last modified:2019-11-13
Method:X-RAY DIFFRACTION (3.200084 Å)
Cite:Bayesian machine learning improves single-wavelength anomalous diffraction phasing.
Acta Crystallogr.,Sect.A, 75, 2019
6Q1Y
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CRYSTAL STRUCTURE OF ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FROM MYCOBACTERIUM AVIUM WITH BOUND NAD
Descriptor:Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ACETATE ION, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2019-08-06
Release date:2019-08-14
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal Structure of Enoyl-[acyl-carrier-protein] reductase from Mycobacterium avium with bound NAD
to be published