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6ULO
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STRUCTURE OF AN N-TERMINALLY TRUNCATED UNCHARACTERIZED PROTEIN FROM LEPTOSPIRA INTERROGANS SEROGROUP ICTEROHAEMORRHAGIAE SEROVAR COPENHAGENI (STRAIN FIOCRUZ L1-130)
Descriptor:Uncharacterized protein, CHLORIDE ION
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2019-10-08
Release date:2019-10-16
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure of an N-terminally truncated uncharacterized protein from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Copenhageni (strain Fiocruz L1-130)
to be published
6ULD
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CRYSTAL STRUCTURE OF SERINE HYDROXYMETHYLTRANSFERASE FROM MYCOBACTERIUM TUBERCULOSIS WITH BOUND PLP FORMING A SCHIFF BASE WITH SUBSTRATE SERINE IN ONE MONOMER AND PLP FORMING A SCHIFF BASE WITH PRODUCT GLYCINE IN THE OTHER MONOMER
Descriptor:Serine hydroxymethyltransferase, PYRIDOXAL-5'-PHOSPHATE, GLYCINE, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2019-10-07
Release date:2019-10-16
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of serine hydroxymethyltransferase from Mycobacterium tuberculosis with bound PLP forming a Schiff base with substrate Serine in one monomer and PLP forming a Schiff base with product Glycine in the other monomer
to be published
6UK3
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CRYSTAL STRUCTURE OF S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE FROM ACANTHAMOEBA CASTELLANII WITH BOUND NAD AND ADENOSINE
Descriptor:Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ADENOSINE, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2019-10-04
Release date:2019-10-16
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal Structure of S-adenosyl-L-homocysteine hydrolase from Acanthamoeba castellanii with bound NAD and Adenosine
to be published
6L2H
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CGTASE MUTANT-Y167H
Descriptor:Alpha-cyclodextrin glucanotransferase, CALCIUM ION
Authors:Fan, T.W., Hou, A.Q., Chao, Y.P., Sun, Y.
Deposit date:2019-10-03
Release date:2019-10-16
Method:X-RAY DIFFRACTION (2.096 Å)
Cite:Structure basis of a mutant a-CGTase tyrosine167histidine from Bacillus sp. 602-1 with enhanced a-CD production
To Be Published
6UJK
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CRYSTAL STRUCTURE OF A PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE (RV1144) FROM MYCOBACTERIUM TUBERCULOSIS WITH BOUND NAD
Descriptor:Uncharacterized oxidoreductase Rv1144, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 1,2-ETHANEDIOL, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2019-10-03
Release date:2019-10-16
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Crystal Structure of a Probable short-chain type dehydrogenase/reductase (Rv1144) from Mycobacterium tuberculosis with bound NAD
to be published
6SZM
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CRYSTAL STRUCTURE OF THE ACVR1 (ALK2) KINASE IN COMPLEX WITH THE COMPOUND M4K2009
Descriptor:Activin receptor type I, 1-[4-[4-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]piperazine, SULFATE ION, ...
Authors:Adamson, R.J., Williams, E.P., Smil, D., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.N.
Deposit date:2019-10-02
Release date:2019-10-16
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2009
To Be Published
6UJD
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CRYSTAL STRUCTURE OF CYSTEINE-TRNA LIGASE FROM ELIZABETHKINGIA SP.
Descriptor:Cysteine--tRNA ligase, ZINC ION, CHLORIDE ION, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2019-10-02
Release date:2019-10-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of Cysteine-tRNA ligase from Elizabethkingia sp.
TO BE PUBLISHED
6SYP
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HUMAN DHODH BOUND TO INHIBITOR IPP/CNRS-A017
Descriptor:Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ...
Authors:Kraemer, A., Janin, Y., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2019-09-30
Release date:2019-10-09
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Human DHODH bound to SGC chemical probe IPP/CNRS-A017-A04
To Be Published
6L1K
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CRYSTAL STRUCTURE OF NADH-DEPENDENT BUTANOL DEHYDROGENASE A FROM FUSOBACTERIUM NUCLEATUM
Descriptor:NADH-dependent butanol dehydrogenase A, PHOSPHATE ION
Authors:Lan, J., Shang, F., Liu, W., Xu, Y., Chen, Y.
Deposit date:2019-09-29
Release date:2019-10-16
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Crystal structure of NADH-dependent butanol dehydrogenase A from Fusobacterium nucleatum
To Be Published
6SYH
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WOLINELLA SUCCINOGENES L-ASPARAGINASE MUTANT V23Q,K24T IN P 22121
Descriptor:L-asparaginase
Authors:Timofeev, V.I., Kuranova, I.P.
Deposit date:2019-09-29
Release date:2019-10-09
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Wolinella succinogenes L-asparaginase mutant V23Q,K24T in P 22121
To Be Published
6UHW
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SOLUTION STRUCTURE OF AN ORGANIC HYDROPEROXIDE RESISTANCE PROTEIN FROM BURKHOLDERIA PSEUDOMALLEI. SEATTLE STRUCTURAL GENOMICS CENTER FOR INFECTIOUS DISEASE TARGET BUPSA.00074.A.
Descriptor:Organic hydroperoxide resistance protein
Authors:Buchko, G.W., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2019-09-29
Release date:2019-10-16
Method:SOLUTION NMR
Cite:Backbone and side chain (1)H, (13)C, and (15)N NMR assignments for the organic hydroperoxide resistance protein (Ohr) from Burkholderia pseudomallei.
Biomol NMR Assign, 3, 2009
6L19
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THE CRYSTAL STRUCTURE OF COMPETENCE OR DAMAGE-INDUCIBLE PROTEIN FROM ENTEROBACTER ASBURIAE
Descriptor:PncC family amidohydrolase, CHLORIDE ION, SODIUM ION, ...
Authors:Wang, L., Chen, Y., Liu, W., Lan, J., Shang, F., Xu, Y.
Deposit date:2019-09-28
Release date:2019-10-16
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:The crystal structure of Competence or damage-inducible protein from Enterobacter asburiae
To Be Published
6L0Z
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THE CRYSTAL STRUCTURE OF SALMONELLA ENTERICA SUGAR-BINDING PROTEIN MALE
Descriptor:Maltodextrin-binding protein, (4S)-2-METHYL-2,4-PENTANEDIOL, METHOXYETHANE, ...
Authors:Wang, L., Chen, Y., Liu, W., Lan, J., Shang, F., Xu, Y.
Deposit date:2019-09-27
Release date:2019-10-16
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The crystal structure of Salmonella enterica sugar-binding protein MalE
To Be Published
6UHD
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CRYSTAL STRUCTURE OF HUMAN HISTONE ACETYLTRANSFERASE 1 (HAT1) IN COMPLEX WITH ISOBUTYRYL-COA AND K12A MUTANT VARIANT OF HISTONE PEPTIDE H4
Descriptor:Histone acetyltransferase type B catalytic subunit, Histone H4, ACETATE ION, ...
Authors:Halabelian, L., Zeng, H., Dong, A., Loppnau, P., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
Deposit date:2019-09-27
Release date:2019-10-16
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of human histone acetyltransferase 1 (HAT1) in complex with Isobutyryl-CoA and K12A mutant variant of histone peptide H4
to be published
6SXW
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CRYSTAL STRUCTURE OF THE FIRST RRM DOMAIN OF HUMAN ZINC FINGER PROTEIN 638 (ZNF638)
Descriptor:Zinc finger protein 638, SULFATE ION
Authors:Newman, J.A., Aitkenhead, H., Wang, D., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2019-09-26
Release date:2019-10-16
Method:X-RAY DIFFRACTION (2.751 Å)
Cite:Crystal structure of the first RRM domain of human Zinc finger protein 638 (ZNF638)
To Be Published
6UGD
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KATANIN HEXAMER IN THE SPIRAL CONFORMATION IN COMPLEX WITH SUBSTRATE
Descriptor:Meiotic spindle formation protein mei-1, Polyglutamate peptide, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Zehr, E.A., Roll-Mecak, A.
Deposit date:2019-09-26
Release date:2019-10-09
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Katanin grips the b-tubulin tail through an electropositive double spiral to sever microtubules
To Be Published
6UGE
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KATANIN HEXAMER IN THE RING CONFORMATION IN COMPLEX WITH SUBSTRATE
Descriptor:Meiotic spindle formation protein mei-1, Polyglutamate peptide, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Zehr, E.A., Roll-Mecak, A.
Deposit date:2019-09-26
Release date:2019-10-09
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Katanin grips the b-tubulin tail through an electropositive double spiral to sever microtubules
To Be Published
6UGF
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KATANIN HEXAMER IN THE RING CONFORMATION WITH RESOLVED PROTOMER ONE IN COMPLEX WITH SUBSTRATE
Descriptor:Meiotic spindle formation protein mei-1, Polyglutamate peptide, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Zehr, E.A., Roll-Mecak, A.
Deposit date:2019-09-26
Release date:2019-10-09
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Katanin grips the b-tubulin tail through an electropositive double spiral to sever microtubules
To Be Published
6UH2
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CRYSTAL STRUCTURE OF SHORT CHAIN DEHYDROGENASE FROM LEPTOSPIRA BORGPETERSENII SEROVAR HARDJO-BOVIS (STRAIN JB197) WITH BOUND NAD+
Descriptor:Short chain dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2019-09-26
Release date:2019-10-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:TBD
TO BE PUBLISHED
6KZU
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MACROCYCLIZATION OF AN ALL-D LINEAR PEPTIDE IMPROVES TARGET AFFINITY AND IMPARTS CELLULAR ACTIVITY: A NOVEL STAPLED ALPHA-HELICAL PEPTIDE MODALITY
Descriptor:E3 ubiquitin-protein ligase Mdm2, 2JN-DAL-E03-DTY-2JN-DSG-TDF-DGL-MK8-DLE-DLE-2JN
Authors:Jiang, S., Brown, C.J.
Deposit date:2019-09-25
Release date:2019-10-16
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Macrocyclization of an all-D linear peptide improves target affinity and imparts cellular activity: A novel stapled alpha-helical peptide modality
To Be Published
6KZW
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CRYSTAL STRUCTURE OF YGGS FAMILY PYRIDOXAL PHOSPHATE-DEPENDENT ENZYME PIPY FROM FUSOBACTERIUM NUCLEATUM
Descriptor:Pyridoxal phosphate homeostasis protein, PHOSPHATE ION
Authors:Chen, Y., Wang, L., Shang, F., Lan, J., Liu, W., Xu, Y.
Deposit date:2019-09-25
Release date:2019-10-16
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Crystal structure of YggS family pyridoxal phosphate-dependent enzyme PipY from Fusobacterium nucleatum
To Be Published
6KZC
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CRYSTAL STRUCTURE OF TRKC IN COMPLEX WITH 3-(IMIDAZO[1,2-A]PYRAZIN-3-YLETHYNYL)-2-METHYL-N-(3-((4- METHYLPIPERAZIN-1-YL)METHYL)-5- (TRIFLUOROMETHYL)PHENYL)BENZAMIDE
Descriptor:NT-3 growth factor receptor, 3-(2-imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methyl-~{N}-[3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]benzamide
Authors:Zhang, Z.M., Wang, Y.
Deposit date:2019-09-23
Release date:2019-10-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design, synthesis and biological evaluation of 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methylbenzamides as potent and selective pan-tropomyosin receptor kinase (TRK) inhibitors.
Eur.J.Med.Chem., 179, 2019
6KZD
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CRYSTAL STRUCTURE OF TRKC IN COMPLEX WITH 3-((6-(4-AMINOPHENYL)IMIDAZO[1,2-A]PYRAZIN-3-YL)ETHYNYL)- N-(3-ISOPROPYL-5-((4-METHYLPIPERAZIN-1-YL)METHYL)PHENYL)-2- METHYLBENZAMIDE
Descriptor:NT-3 growth factor receptor, 3-[2-[6-(4-aminophenyl)imidazo[1,2-a]pyrazin-3-yl]ethynyl]-2-methyl-~{N}-[3-(4-methylpiperazin-1-yl)-5-propan-2-yl-phenyl]benzamide, PHOSPHATE ION
Authors:Wang, Y., Zhang, Z.M.
Deposit date:2019-09-23
Release date:2019-10-09
Method:X-RAY DIFFRACTION (1.708 Å)
Cite:Design, synthesis and biological evaluation of 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methylbenzamides as potent and selective pan-tropomyosin receptor kinase (TRK) inhibitors.
Eur.J.Med.Chem., 179, 2019
6UEV
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STRUCTURE OF UNLIGANDED TRNA (GUANINE-N1)-METHYLTRANSFERASE FOUND IN ANAPLASMA PHAGOCYTOPHILUM
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, GLYCEROL
Authors:Jannotta, C., Edele, D., Levanti, D., Carson, M., Prucha, G., Caesar, J., Collins, K., Garland, E., Handley-Pendleton, J., Hernandez, V., Leffler, S., Williams, D., Stojanoff, V., Perez, A., Halloran, J., Bolen, R.
Deposit date:2019-09-23
Release date:2019-10-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of unliganded tRNA (guanine-N1)-methyltransferase found in Anaplasma phagocytophilum
To Be Published
6KYL
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CRYSTAL STRUCTURE OF PHOSPHATIDIC ACID TRANSPORTER UPS1/MDM35 IN COMPLEX WITH (2R)-3-(PHOSPHONOOXY)PROPANE-1,2-DIYL DIHEXANOATE
Descriptor:Mitochondrial distribution and morphology protein 35, Protein UPS1, mitochondrial, ...
Authors:Lu, J., Chan, K.C., Zhai, Y., Fan, J., Sun, F.
Deposit date:2019-09-19
Release date:2019-10-02
Method:X-RAY DIFFRACTION (3.55 Å)
Cite:Structure of a phospholipid transport complex
To Be Published