Mine: Advanced search results

Advanced query:
Add keyword:
Search
Go to Advanced search
6PED
  • Download 6ped
  • View 6ped
Molmil generated image of 6ped
CRYSTAL STRUCTURE OF HEMK2-TRMT112 COMPLEX
Descriptor:Methyltransferase N6AMT1, Multifunctional methyltransferase subunit TRM112-like protein, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Dong, C., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2019-06-20
Release date:2019-07-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of HEMK2-TRMT112 complex
To Be Published
6PET
  • Download 6pet
  • View 6pet
Molmil generated image of 6pet
CRYSTAL STRUCTURE OF 8-HYDROXYCHROMENE COMPOUND 30 BOUND TO ESTROGEN RECEPTOR ALPHA
Descriptor:Estrogen receptor, (2S)-3-(3-hydroxyphenyl)-2-(4-iodophenyl)-4-methyl-2H-1-benzopyran-6-ol, (2S)-2-(4-{2-[3-(fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-3-(3-hydroxyphenyl)-4-methyl-2H-1-benzopyran-8-ol, ...
Authors:Kiefer, J.R., Vinogradova, M., Liang, J., Wang, X., Zbieg, J., Labadie, S.S., Zhang, B., Li, J., Liang, W.
Deposit date:2019-06-20
Release date:2019-07-17
Method:X-RAY DIFFRACTION (2.203 Å)
Cite:Discovery of a C-8 Hydroxychromene as a Potent Degrader of Estrogen Receptor alpha with Improved Rat Oral Exposure over GDC-0927
Bioorg.Med.Chem.Lett., 2019
6K9U
  • Download 6k9u
  • View 6k9u
Molmil generated image of 6k9u
DISCOVERY OF PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVE AS A HIGHLY SELECTIVE PDE10A INHIBITOR
Descriptor:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ...
Authors:Takedomi, K., Koizumi, Y.
Deposit date:2019-06-18
Release date:2019-07-17
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Discovery of a pyrazolo[1,5-a]pyrimidine derivative (MT-3014) as a highly selective PDE10A inhibitor via core structure transformation from the stilbene moiety.
Bioorg.Med.Chem., 2019
6S11
  • Download 6s11
  • View 6s11
Molmil generated image of 6s11
CRYSTAL STRUCTURE OF DYRK1A WITH SMALL MOLECULE INHIBITOR
Descriptor:Dual specificity tyrosine-phosphorylation-regulated kinase 1A, CHLORIDE ION, 6-pyridin-4-yl-3-[3-(trifluoromethyloxy)phenyl]imidazo[1,2-b]pyridazine
Authors:Sorrell, F.J., Henderson, S.H., Redondo, C., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Elkins, J.M.
Deposit date:2019-06-18
Release date:2019-06-26
Method:X-RAY DIFFRACTION (2.445 Å)
Cite:Kinase Scaffold Repurposing in the Public Domain
To be published
6S14
  • Download 6s14
  • View 6s14
Molmil generated image of 6s14
CRYSTAL STRUCTURE OF DYRK1A WITH SMALL MOLECULE INHIBITOR
Descriptor:Dual specificity tyrosine-phosphorylation-regulated kinase 1A, SULFATE ION, ~{N}-cyclopropyl-~{N}-methyl-4-pyrazolo[1,5-b]pyridazin-3-yl-pyrimidin-2-amine
Authors:Sorrell, F.J., Henderson, S.H., Redondo, C., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Elkins, J.M.
Deposit date:2019-06-18
Release date:2019-06-26
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Kinase Scaffold Repurposing in the Public Domain
To be published
6S17
  • Download 6s17
  • View 6s17
Molmil generated image of 6s17
CRYSTAL STRUCTURE OF DYRK1A WITH SMALL MOLECULE INHIBITOR
Descriptor:Dual specificity tyrosine-phosphorylation-regulated kinase 1A, SULFATE ION, 1,2-ETHANEDIOL, ...
Authors:Sorrell, F.J., Henderson, S.H., Redondo, C., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Elkins, J.M.
Deposit date:2019-06-18
Release date:2019-06-26
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Kinase Scaffold Repurposing in the Public Domain
To be published
6S1B
  • Download 6s1b
  • View 6s1b
Molmil generated image of 6s1b
CRYSTAL STRUCTURE OF DYRK1A WITH SMALL MOLECULE INHIBITOR
Descriptor:Dual specificity tyrosine-phosphorylation-regulated kinase 1A, SULFATE ION, ~{N}-methyl-4-pyrazolo[1,5-b]pyridazin-3-yl-pyrimidin-2-amine, ...
Authors:Sorrell, F.J., Henderson, S.H., Redondo, C., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Elkins, J.M.
Deposit date:2019-06-18
Release date:2019-06-26
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Kinase Scaffold Repurposing in the Public Domain
To be published
6S1H
  • Download 6s1h
  • View 6s1h
Molmil generated image of 6s1h
CRYSTAL STRUCTURE OF DYRK1A WITH SMALL MOLECULE INHIBITOR
Descriptor:Dual specificity tyrosine-phosphorylation-regulated kinase 1A, SULFATE ION, ~{N},~{N}-dimethyl-4-(1~{H}-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine, ...
Authors:Sorrell, F.J., Henderson, S.H., Redondo, C., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Elkins, J.M.
Deposit date:2019-06-18
Release date:2019-06-26
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Kinase Scaffold Repurposing in the Public Domain
To be published
6S1I
  • Download 6s1i
  • View 6s1i
Molmil generated image of 6s1i
CRYSTAL STRUCTURE OF DYRK1A WITH SMALL MOLECULE INHIBITOR
Descriptor:Dual specificity tyrosine-phosphorylation-regulated kinase 1A, SULFATE ION, TETRAETHYLENE GLYCOL, ...
Authors:Sorrell, F.J., Henderson, S.H., Redondo, C., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Elkins, J.M.
Deposit date:2019-06-18
Release date:2019-06-26
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Kinase Scaffold Repurposing in the Public Domain
To be published
6S1J
  • Download 6s1j
  • View 6s1j
Molmil generated image of 6s1j
CRYSTAL STRUCTURE OF DYRK1A WITH SMALL MOLECULE INHIBITOR
Descriptor:Dual specificity tyrosine-phosphorylation-regulated kinase 1A, 3-[2-[(3~{S})-3-fluoranylpyrrolidin-1-yl]pyrimidin-4-yl]pyrazolo[1,5-b]pyridazine, 1,2-ETHANEDIOL, ...
Authors:Sorrell, F.J., Henderson, S.H., Redondo, C., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Elkins, J.M.
Deposit date:2019-06-18
Release date:2019-06-26
Method:X-RAY DIFFRACTION (1.408 Å)
Cite:Kinase Scaffold Repurposing in the Public Domain
To be published
6S0O
  • Download 6s0o
  • View 6s0o
Molmil generated image of 6s0o
CRYSTAL STRUCTURE OF TWO-DOMAIN LACCASE FROM STREPTOMYCES GRISEOFLAVUS PRODUCED AT 0.25 MM COPPER SULFATE IN GROWTH MEDIUM
Descriptor:Two-domain laccase, COPPER (II) ION, HYDROGEN PEROXIDE, ...
Authors:Gabdulkhakov, A.G., Tishchenko, T.V., Kolyadenko, I.A.
Deposit date:2019-06-17
Release date:2019-07-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Investigations of Accessibility of T2/T3 Copper Center of Two-Domain Laccase fromStreptomyces griseoflavusAc-993.
Int J Mol Sci, 20, 2019
6PBR
  • Download 6pbr
  • View 6pbr
Molmil generated image of 6pbr
CATALYTIC DOMAIN OF E.COLI DIHYDROLIPOAMIDE SUCCINYLTRANSFERASE IN I4 SPACE GROUP
Descriptor:Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, SODIUM ION
Authors:Andi, B., Soares, A., Shi, W., McSweeney, S., Liu, Q.
Deposit date:2019-06-14
Release date:2019-06-26
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the dihydrolipoamide succinyltransferase catalytic domain from Escherichia coli in a novel crystal form: a tale of a common protein crystallization contaminant
To Be Published
6S07
  • Download 6s07
  • View 6s07
Molmil generated image of 6s07
STRUCTURE OF FORMYLGLYCINE-GENERATING ENZYME AT 1.04 A IN COMPLEX WITH COPPER AND SUBSTRATE REVEALS AN ACIDIC POCKET FOR BINDING AND ACTI-VATION OF MOLECULAR OXYGEN.
Descriptor:Formylglycine-generating enzyme, Abz-ALA-THR-THR-PRO-LEU-CYS-GLY-PRO-SER-ARG-ALA-SER-ILE-LEU-SER-GLY-ARG, COPPER (I) ION, ...
Authors:Leisinger, F., Miarzlou, D.A., Seebeck, F.P.
Deposit date:2019-06-14
Release date:2019-06-26
Method:X-RAY DIFFRACTION (1.04 Å)
Cite:Structure of formylglycine-generating enzyme in complex with copper and a substrate reveals an acidic pocket for binding and activation of molecular oxygen
Chem Sci, 2019
6PBB
  • Download 6pbb
  • View 6pbb
Molmil generated image of 6pbb
CRYSTAL STRUCTURE OF HEN EGG WHITE LYSOZYME IN COMPLEX WITH I3C
Descriptor:Lysozyme, 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid, CHLORIDE ION
Authors:Truong, J.Q.
Deposit date:2019-06-13
Release date:2019-07-10
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.891511 Å)
Cite:Combining random microseed matrix screening and the magic triangle for the efficient structure solution of a potential lysin from bacteriophage P68
Acta Crystallogr.,Sect.D, 2019
6PBG
  • Download 6pbg
  • View 6pbg
Molmil generated image of 6pbg
CRYSTAL STRUCTURE OF WD-REPEAT DOMAIN OF HUMAN COATOMER SUBUNIT ALPHA (COPA)
Descriptor:Coatomer subunit alpha, L(+)-TARTARIC ACID, UNKNOWN ATOM OR ION
Authors:Halabelian, L., Zeng, H., Dong, A., Loppnau, P., Seitova, A., Hutchinson, A., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
Deposit date:2019-06-13
Release date:2019-06-26
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Crystal structure of W repeat domain of human coatomer subunit Alpha (COPA)
to be published
6RZA
  • Download 6rza
  • View 6rza
Molmil generated image of 6rza
CRYO-EM STRUCTURE OF THE HUMAN INNER ARM DYNEIN DNAH7 MICROTUBULE BINDING DOMAIN BOUND TO MICROTUBULES
Descriptor:Cytoplasmic dynein 1 heavy chain 1,Dynein heavy chain 7, axonemal,Cytoplasmic dynein 1 heavy chain 1, Tubulin alpha-1B chain, ...
Authors:Lacey, S.E., He, S., Scheres, S.H.W., Carter, A.P.
Deposit date:2019-06-13
Release date:2019-07-10
Last modified:2019-07-17
Method:ELECTRON MICROSCOPY (5.4 Å)
Cite:Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule.
Elife, 8, 2019
6RZB
  • Download 6rzb
  • View 6rzb
Molmil generated image of 6rzb
CRYO-EM STRUCTURE OF MOUSE CYTOPLASMIC DYNEIN-1 MICROTUBULE BINDING DOMAIN BOUND TO MICROTUBULES
Descriptor:Tubulin alpha-1B chain, Tubulin beta chain, MKIAA0325 protein, ...
Authors:Lacey, S.E., He, S., Scheres, S.H.W., Carter, A.P.
Deposit date:2019-06-13
Release date:2019-07-10
Last modified:2019-07-17
Method:ELECTRON MICROSCOPY (5 Å)
Cite:Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule.
Elife, 8, 2019
6RZP
  • Download 6rzp
  • View 6rzp
Molmil generated image of 6rzp
MULTICRYSTAL STRUCTURE OF PROTEINASE K AT ROOM TEMPERATURE USING A MULTILAYER MONOCHROMATOR.
Descriptor:Proteinase K, GLYCEROL, SULFATE ION, ...
Authors:Sandy, J., Sandy, E., Sanchez-Weatherby, J., Mikolajek, H.
Deposit date:2019-06-13
Release date:2019-07-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Multicrystal structure of Proteinase K at room temperature using a multilayer monochromator.
To Be Published
6RZZ
  • Download 6rzz
  • View 6rzz
Molmil generated image of 6rzz
CRYO-EM STRUCTURES OF LSG1-TAP PRE-60S RIBOSOMAL PARTICLES
Descriptor:25S ribosomal RNA, 60S ribosomal protein L2-A, 60S ribosomal protein L3, ...
Authors:Kargas, V., Warren, A.J.
Deposit date:2019-06-13
Release date:2019-06-26
Last modified:2019-07-10
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Mechanism of completion of peptidyltransferase centre assembly in eukaryotes.
Elife, 8, 2019
6S05
  • Download 6s05
  • View 6s05
Molmil generated image of 6s05
CRYO-EM STRUCTURES OF LSG1-TAP PRE-60S RIBOSOMAL PARTICLES
Descriptor:25S ribosomal RNA, 60S ribosomal protein L2-A, 60S ribosomal protein L3, ...
Authors:Kargas, V., Warren, A.J.
Deposit date:2019-06-13
Release date:2019-06-26
Last modified:2019-07-10
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Mechanism of completion of peptidyltransferase centre assembly in eukaryotes.
Elife, 8, 2019
6RYS
  • Download 6rys
  • View 6rys
Molmil generated image of 6rys
ENGINEERED BETA-LACTOGLOBULIN: VARIANT F105L
Descriptor:Beta-lactoglobulin
Authors:Loch, J.I., Gotkowski, M., Lewinski, K.
Deposit date:2019-06-11
Release date:2019-06-26
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Engineered beta-lactoglobulin: variant F105L
To Be Published
6RYT
  • Download 6ryt
  • View 6ryt
Molmil generated image of 6ryt
ENGINEERED BETA-LACTOGLOBULIN: VARIANT M107L
Descriptor:Beta-lactoglobulin, GLYCEROL, PHOSPHATE ION
Authors:Loch, J.I., Kurpiewska, K., Lewinski, K.
Deposit date:2019-06-11
Release date:2019-06-26
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Engineered beta-lactoglobulin: variant M107L
To Be Published
6P9E
  • Download 6p9e
  • View 6p9e
Molmil generated image of 6p9e
CRYSTAL STRUCTURE OF IL-36GAMMA COMPLEXED TO A-552
Descriptor:Interleukin-36 gamma, (2S)-2-{[4-(3-amino-4-methylphenyl)-6-methylpyrimidin-2-yl]oxy}-3-methoxy-3,3-diphenylpropanoic acid
Authors:Argiriadi, M.A., Todorovic, T., Su, Z., Putman, B., Kakavas, S.J., Salte, K.M., McDonald, H.A., Wetter, J.B., Paulsboe, S.E., Sun, Q., Gerstein, C.E., Medina, L., Sielaff, B., Sadhukhan, R., Stockmann, H., Richardson, P.L., Qiu, W., Henry, R.F., Herold, J.M., Shotwell, J.B., McGaraughty, S.P., Honore, P., Gopalakrishnan, S.M., Sun, C.C., Scott, V.E.
Deposit date:2019-06-10
Release date:2019-06-26
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Small Molecule IL-36 gamma Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis.
Sci Rep, 9, 2019
6P9F
  • Download 6p9f
  • View 6p9f
Molmil generated image of 6p9f
CRYSTAL STRUCTURE OF RAR-RELATED ORPHAN RECEPTOR C (NHIS-RORGT(244-487)-L6-SRC1(678-692)) IN COMPLEX WITH A PHENYL (3-PHENYLPYRROLIDIN-3-YL)SULFONE INHIBITOR
Descriptor:Nuclear receptor ROR-gamma, Nuclear receptor coactivator 1 chimera, trans-4-{(3R)-3-[(4-fluorophenyl)sulfonyl]-3-[4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)phenyl]pyrrolidine-1-carbonyl}cyclohexane-1-carboxylic acid
Authors:Sack, J.
Deposit date:2019-06-10
Release date:2019-07-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as ROR gamma t inverse agonists.
Bioorg.Med.Chem.Lett., 2019
6K7O
  • Download 6k7o
  • View 6k7o
Molmil generated image of 6k7o
COMPLEX STRUCTURE OF LILRB4 AND H128-3 ANTIBODY
Descriptor:Leukocyte immunoglobulin-like receptor subfamily B member 4, h128-3 Fab heavy chain, h128-3 Fab light chain
Authors:Song, H., Chai, Y., Xu, X., Gao, F.G.
Deposit date:2019-06-08
Release date:2019-07-03
Method:X-RAY DIFFRACTION (3.004 Å)
Cite:Disrupting LILRB4/APOE interaction by an efficacious humanized antibody reverses T-cell suppression and blocks AML development.
Cancer Immunol Res, 2019