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6X7V
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CRYSTAL STRUCTURE OF THE HUMAN NUDIX HYDROLASE NUDT16
Descriptor:U8 snoRNA-decapping enzyme, MANGANESE (II) ION, CHLORIDE ION
Authors:Hamilton, K., Tong, L.
Deposit date:2020-05-30
Release date:2020-07-01
Last modified:2020-07-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mammalian Nudix proteins cleave nucleotide metabolite caps on RNAs.
Nucleic Acids Res., 48, 2020
6Z7F
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C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH N-(2-(1H-IMIDAZOL-4-YL)ETHYL)-4-ACETAMIDO-3-(BENZYLOXY)BENZAMIDE
Descriptor:Bromodomain-containing protein 2, DI(HYDROXYETHYL)ETHER, 1,2-ETHANEDIOL, ...
Authors:Chung, C.
Deposit date:2020-05-30
Release date:2020-07-29
Method:X-RAY DIFFRACTION (1.605 Å)
Cite:The Design and Synthesis of a Highly Selective and In Vivo Capable Inhibitor of the Second Bromodomain (BD2) of the Bromodomain and Extra Terminal Domain (BET) Family of Proteins.
J.Med.Chem., 2020
6Z7G
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N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH N-(2-(1H-IMIDAZOL-4-YL)ETHYL)-4-ACETAMIDO-3-(BENZYLOXY)BENZAMIDE
Descriptor:Bromodomain-containing protein 4, N-(2-(1H-imidazol-4-yl)ethyl)-4-acetamido-3-(benzyloxy)benzamide
Authors:Chung, C.
Deposit date:2020-05-30
Release date:2020-07-29
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:The Design and Synthesis of a Highly Selective and In Vivo Capable Inhibitor of the Second Bromodomain (BD2) of the Bromodomain and Extra Terminal Domain (BET) Family of Proteins.
J.Med.Chem., 2020
6X7B
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BRD4 BROMODOMAIN 1 IN COMPLEX WITH MULTI-ACTION INHIBITOR SRX3212P
Descriptor:Bromodomain-containing protein 4, 7-[7-oxo-5-(piperazin-1-yl)-7H-thieno[3,2-b]pyran-3-yl]-N-[(pyridin-3-yl)methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide
Authors:Vann, K.R., Kutateladze, T.G.
Deposit date:2020-05-29
Release date:2020-08-05
Method:X-RAY DIFFRACTION (1.951 Å)
Cite:Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets.
Sci Rep, 10, 2020
6X7C
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BRD4 BROMODOMAIN 1 IN COMPLEX WITH MULTI-ACTION INHIBITOR SRX3212
Descriptor:Bromodomain-containing protein 4, 7-[5-(morpholin-4-yl)-7-oxo-7H-thieno[3,2-b]pyran-3-yl]-N-[(pyridin-3-yl)methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide
Authors:Vann, K.R., Kutateladze, T.G.
Deposit date:2020-05-29
Release date:2020-08-05
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets.
Sci Rep, 10, 2020
6X7D
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BRD4 BROMODOMAIN 1 IN COMPLEX WITH MULTI-ACTION INHIBITOR SF2523P
Descriptor:Bromodomain-containing protein 4, 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(piperazin-1-yl)-7H-thieno[3,2-b]pyran-7-one
Authors:Vann, K.R., Kutateladze, T.G.
Deposit date:2020-05-29
Release date:2020-08-05
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets.
Sci Rep, 10, 2020
6Z6S
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CRYSTAL STRUCTURE OF UBA4-URM1 FROM CHAETOMIUM THERMOPHILUM
Descriptor:Adenylyltransferase and sulfurtransferase uba4, Ubiquitin-related modifier 1, ZINC ION
Authors:Grudnik, P., Pabis, M., Ethiraju Ravichandran, K., Glatt, S.
Deposit date:2020-05-29
Release date:2020-07-22
Method:X-RAY DIFFRACTION (3.153 Å)
Cite:Molecular basis for the bifunctional Uba4-Urm1 sulfur relay system in tRNA thiolation and ubiquitin-like conjugation
To Be Published
6Z6U
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1.25 A STRUCTURE OF HUMAN APOFERRITIN OBTAINED FROM TITAN MONO-BCOR MICROSCOPE
Descriptor:Ferritin heavy chain, SODIUM ION, MAGNESIUM ION
Authors:Yip, K.M., Fischer, N., Paknia, E., Chari, A., Stark, H.
Deposit date:2020-05-29
Release date:2020-06-24
Method:ELECTRON MICROSCOPY (1.25 Å)
Cite:1.25 A structure of human apoferritin obtained from Titan Mono-BCOR microscope
To Be Published
6Z6V
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GLOBULAR HEAD OF C1Q IN COMPLEX WITH THE NANOBODY C1QNB75
Descriptor:Complement C1q subcomponent subunit A, Complement C1q subcomponent subunit B, Complement C1q subcomponent subunit C, ...
Authors:Laursen, N.S., Andersen, G.R.
Deposit date:2020-05-29
Release date:2020-06-10
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Functional and structural characterization of a potent C1q inhibitor targeting the classical pathway of the complement system
To Be Published
6X6P
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CHARACTERIZATION OF THE SARS-COV-2 S PROTEIN: BIOPHYSICAL, BIOCHEMICAL, STRUCTURAL, AND ANTIGENIC ANALYSIS
Descriptor:SARS-CoV-2 spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Herrera, N.G., Morano, N.C., Celikgil, A., Georgiev, G.I., Malonis, R., Lee, J.H., Tong, K., Vergnolle, O., Massimi, A., Yen, L.Y., Noble, A.J., Kopylov, M., Bonanno, J.B., Garrett-Thompson, S.C., Hayes, D.B., Brenowitz, M., Garforth, S.J., Eng, E.T., Lai, J.R., Almo, S.C.
Deposit date:2020-05-28
Release date:2020-06-10
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.22 Å)
Cite:Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis.
Biorxiv, 2020
6Z6B
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STRUCTURE OF FULL-LENGTH LA CROSSE VIRUS L PROTEIN (POLYMERASE)
Descriptor:RNA (5'-R(P*AP*GP*UP*AP*GP*UP*GP*UP*GP*C)-3'), RNA (5'-R(P*UP*UP*AP*GP*UP*AP*GP*UP*AP*CP*AP*CP*UP*AP*CP*U)-3'), RNA (5'-R(*GP*CP*UP*AP*CP*UP*AP*A)-3'), ...
Authors:Cusack, S., Gerlach, P., Reguera, J.
Deposit date:2020-05-28
Release date:2020-07-29
Method:X-RAY DIFFRACTION (3.961 Å)
Cite:Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes.
Nat Commun, 11, 2020
6Z6G
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CRYO-EM STRUCTURE OF LA CROSSE VIRUS POLYMERASE AT PRE-INITIATION STAGE
Descriptor:5'vRNA 1-10, 5'vRNA 9-16, 3'vRNA 1-16, ...
Authors:Arragain, B., Effantin, G., Gerlach, P., Reguera, J., Schoehn, G., Cusack, S., Malet, H.
Deposit date:2020-05-28
Release date:2020-07-29
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes.
Nat Commun, 11, 2020
6Z6J
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CRYO-EM STRUCTURE OF YEAST LSO2 BOUND TO 80S RIBOSOMES UNDER NATIVE CONDITION
Descriptor:18S rRNA, Protein LSO2, 25S rRNA, ...
Authors:Wells, J.N., Buschauer, R., Mackens-Kiani, T., Best, K., Kratzat, H., Berninghausen, O., Becker, T., Cheng, J., Beckmann, R.
Deposit date:2020-05-28
Release date:2020-07-29
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes.
Plos Biol., 18, 2020
6Z6K
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CRYO-EM STRUCTURE OF YEAST RECONSTITUTED LSO2 BOUND TO 80S RIBOSOMES
Descriptor:18S rRNA, Protein LSO2, 25S rRNA, ...
Authors:Wells, J.N., Buschauer, R., Mackens-Kiani, T., Best, K., Kratzat, H., Berninghausen, O., Becker, T., Cheng, J., Beckmann, R.
Deposit date:2020-05-28
Release date:2020-07-29
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes.
Plos Biol., 18, 2020
6Z6L
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CRYO-EM STRUCTURE OF HUMAN CCDC124 BOUND TO 80S RIBOSOMES
Descriptor:28S rRNA, 5S rRNA, 5.8S rRNA, ...
Authors:Wells, J.N., Buschauer, R., Mackens-Kiani, T., Best, K., Kratzat, H., Berninghausen, O., Becker, T., Cheng, J., Beckmann, R.
Deposit date:2020-05-28
Release date:2020-07-29
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes.
Plos Biol., 18, 2020
6Z6M
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CRYO-EM STRUCTURE OF HUMAN 80S RIBOSOMES BOUND TO EBP1, EEF2 AND SERBP1
Descriptor:28S rRNA, 5S rRNA, 5.8S rRNA, ...
Authors:Wells, J.N., Buschauer, R., Mackens-Kiani, T., Best, K., Kratzat, H., Berninghausen, O., Becker, T., Cheng, J., Beckmann, R.
Deposit date:2020-05-28
Release date:2020-07-29
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes.
Plos Biol., 18, 2020
6Z6N
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CRYO-EM STRUCTURE OF HUMAN EBP1-80S RIBOSOMES (FOCUS ON EBP1)
Descriptor:28S rRNA, 5S rRNA, 5.8S rRNA, ...
Authors:Wells, J.N., Buschauer, R., Mackens-Kiani, T., Best, K., Kratzat, H., Berninghausen, O., Becker, T., Cheng, J., Beckmann, R.
Deposit date:2020-05-28
Release date:2020-07-29
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes.
Plos Biol., 18, 2020
7C80
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E30 F-PARTICLE IN COMPLEX WITH 4B10
Descriptor:Light chain, Heavy chain, VP1, ...
Authors:Wang, K., Zheng, B., Zhang, L., Cui, L., Su, X., Zhang, Q., Guo, Y., Zhu, L., Zhu, F., Rao, Z., Wang, X.
Deposit date:2020-05-28
Release date:2020-07-29
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B
To Be Published
7C81
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E30 F-PARTICLE IN COMPLEX WITH 6C5
Descriptor:VP1, VP2, VP3, ...
Authors:Wang, K., Zheng, B., Zhang, L., Cui, L., Su, X., Zhang, Q., Guo, Y., Zhu, L., Zhu, F., Rao, Z., Wang, X.
Deposit date:2020-05-28
Release date:2020-07-29
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B.
To Be Published
7C82
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CRYSTAL STRUCTURE OF ALINE4, A SGNH-HYDROLASE FAMILY ESTERASE
Descriptor:SGNH-hydrolase family esterase, ALANINE, CADMIUM ION, ...
Authors:Li, Z., Li, J.
Deposit date:2020-05-28
Release date:2020-07-08
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Structure-guided protein engineering increases enzymatic activities of the SGNH family esterases.
Biotechnol Biofuels, 13, 2020
7C84
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ESTERASE ALINE4 MUTANT, D162A
Descriptor:SGNH-hydrolase family esterase, CADMIUM ION, ACETATE ION, ...
Authors:Li, Z., Li, J.
Deposit date:2020-05-28
Release date:2020-07-08
Method:X-RAY DIFFRACTION (1.552 Å)
Cite:Structure-guided protein engineering increases enzymatic activities of the SGNH family esterases.
Biotechnol Biofuels, 13, 2020
7C85
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ESTERASE ALINE4 MUTANT-S13A
Descriptor:SGNH-hydrolase family esterase, CADMIUM ION, ACETATE ION
Authors:Li, Z., Li, J.
Deposit date:2020-05-28
Release date:2020-07-08
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure-guided protein engineering increases enzymatic activities of the SGNH family esterases.
Biotechnol Biofuels, 13, 2020
6X5Z
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BOVINE CARDIAC MYOSIN IN COMPLEX WITH CHICKEN SKELETAL ACTIN AND HUMAN CARDIAC TROPOMYOSIN IN THE RIGOR STATE
Descriptor:Actin, alpha skeletal muscle, Tropomyosin alpha-1 chain, ...
Authors:Doran, M.H., Lehman, W., Rynkiewicz, M.J., Bullitt, E.
Deposit date:2020-05-27
Release date:2020-07-22
Last modified:2020-08-12
Method:ELECTRON MICROSCOPY (4.24 Å)
Cite:Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments.
Biophys.J., 2020
6X60
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CLPP2 FROM CHLAMYDIA TRACHOMATIS WITH RESOLVED HANDLE LOOP
Descriptor:ATP-dependent Clp protease proteolytic subunit 2
Authors:Azadmanesh, J., Struble, L.R., Seleem, M.A., Ouellette, S., Conda-Sheridan, M., Borgstahl, G.E.O.
Deposit date:2020-05-27
Release date:2020-06-03
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:ClpP2 from Chlamydia trachomatis with resolved handle loop
To Be Published
6X67
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CRYO-EM STRUCTURE OF PIGGYBAC TRANSPOSASE STRAND TRANSFER COMPLEX (STC)
Descriptor:Transposase, DNA (37-MER), DNA (47-MER), ...
Authors:Chen, Q., Hickman, A.B., Dyda, F.
Deposit date:2020-05-27
Release date:2020-07-22
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:Structural basis of seamless excision and specific targeting by piggyBac transposase
Nat Commun, 11, 2020
167518
PDB entries from 2020-08-12