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6WE5
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CRYSTAL STRUCTURE OF AN INORGANIC PYROPHOSPHATASE FROM CHLAMYDIA TRACHOMATIS D/UW-3/CX
Descriptor:Inorganic pyrophosphatase, SODIUM ION
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2020-04-01
Release date:2020-04-08
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of an inorganic pyrophosphatase from Chlamydia trachomatis D/UW-3/Cx
To Be Published
7BTF
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SARS-COV-2 RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH COFACTORS IN REDUCED CONDITION
Descriptor:SARS-Cov-2 NSP12, SARS-Cov-2 NSP7, SARS-Cov-2 NSP8, ...
Authors:Gao, Y., Yan, L., Huang, Y., Liu, F., Cao, L., Wang, T., Wang, Q., Lou, Z., Rao, Z.
Deposit date:2020-04-01
Release date:2020-04-08
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Structure of RNA-dependent RNA polymerase from 2019-nCoV, a major antiviral drug target
Biorxiv, 2020
6WCT
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CRYSTAL STRUCTURE OF A GUANYLATE KINASE FROM STENOTROPHOMONAS MALTOPHILIA K279A BOUND TO GUANOSINE-5'-MONOPHOSPHATE
Descriptor:Guanylate kinase, GUANOSINE-5'-MONOPHOSPHATE, PHOSPHATE ION, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2020-03-31
Release date:2020-04-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of a guanylate kinase from Stenotrophomonas maltophilia K279a bound to guanosine-5'-monophosphate
To Be Published
6YI3
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THE N-TERMINAL RNA-BINDING DOMAIN OF THE SARS-COV-2 NUCLEOCAPSID PHOSPHOPROTEIN
Descriptor:N-NTD
Authors:Veverka, V., Boura, E.
Deposit date:2020-03-31
Release date:2020-04-08
Method:SOLUTION NMR
Cite:The N-terminal RNA-binding domain of the SARS-CoV-2 nucleocapsid phosphoprotein
To Be Published
6YI4
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STRUCTURE OF IMP-13 METALLO-BETA-LACTAMASE COMPLEXED WITH CITRATE ANION
Descriptor:Beta-lactamase, 1,2-ETHANEDIOL, CITRATE ANION, ...
Authors:Zak, K.M., Zhou, R.X., Softley, C.A., Bostock, M.J., Sattler, M., Popowicz, G.M.
Deposit date:2020-03-31
Release date:2020-04-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of IMP-13 metallo-beta-lactamase complexed with citrate anion
Not published
6WCI
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CRYSTAL STRUCTURE OF A CYSTEINE DESULFURASE SUFS FROM STENOTROPHOMONAS MALTOPHILIA K279A
Descriptor:Cysteine desulfurase, 1,2-ETHANEDIOL, SULFATE ION
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2020-03-30
Release date:2020-04-08
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of a cysteine desulfurase SufS from Stenotrophomonas maltophilia K279a
To Be Published
6YHE
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TRNA-GUANINE TRANSGLYCOSYLASE (TGT) LABELED WITH 5-FLUOROTRYPTOPHAN IN CO-CRYSTALLIZED COMPLEX WITH 6-AMINO-4-(2-((3AR,4R,6R,6AR)-6-METHOXY-2,2-DIMETHYLTETRAHYDROFURO[3,4-D][1,3]DIOXOL-4-YL)ETHYL)-2-(METHYLAMINO)-1H-IMIDAZO[4,5-G]QUINAZOLIN-8(7H)-ONE
Descriptor:Queuine tRNA-ribosyltransferase, ZINC ION, 4-[2-[(3~{a}~{R},4~{R},6~{R},6~{a}~{R})-4-methoxy-2,2-dimethyl-3~{a},4,6,6~{a}-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]ethyl]-6-azanyl-2-(methylamino)-1,7-dihydroimidazo[4,5-g]quinazolin-8-one
Authors:Nguyen, A., Heine, A., Klebe, G.
Deposit date:2020-03-29
Release date:2020-04-08
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Co-crystallization, 19F NMR and nanoESI-MS reveal dimer disturbing inhibitors and conformational changes at dimer contacts
To Be Published
6YGY
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TRNA-GUANINE TRANSGLYCOSYLASE (TGT) LABELED WITH 5-FLUOROTRYPTOPHAN IN CO-CRYSTALLIZED COMPLEX WITH 6-AMINO-4-[2-(4-METHYLPHENYL)ETHYL]-1,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE
Descriptor:Queuine tRNA-ribosyltransferase, ZINC ION, 6-AMINO-4-[2-(4-METHYLPHENYL)ETHYL]-1,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE
Authors:Nguyen, A., Heine, A., Klebe, G.
Deposit date:2020-03-28
Release date:2020-04-08
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Co-crystallization, nanoESI-MS and 19F NMR reveal dimer disturbing inhibitors and conformational changes at dimer contacts
To Be Published
6YGZ
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TRNA GUANINE TRANSGLYCOSYLASE (TGT) LABELLED WITH 5-FLUORO-TRYPTOPHAN IN CO-CRYSTALLIZED COMPLEX WITH 6-AMINO-4-(2-PHENYLETHYL)-1,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE
Descriptor:Queuine tRNA-ribosyltransferase, ZINC ION, 6-AMINO-4-(2-PHENYLETHYL)-1,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE
Authors:Nguyen, A., Heine, A., Klebe, G.
Deposit date:2020-03-28
Release date:2020-04-08
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Co-crystallization, 19F NMR and nanoESI-MS reveal dimer disturbing inhibitors and conformational changes at dimer contacts
To Be Published
6YH1
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TRNA-GUANINE TRANSGLYCOSYLASE (TGT) LABELED WITH 5-FLUOROTRYPTOPHAN IN CO-CRYSTALLIZED COMPLEX WITH 6-AMINO-2-(METHYLAMINO)-4-(4-(TRIFLUOROMETHYL)PHENETHYL)-3,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE
Descriptor:Queuine tRNA-ribosyltransferase, ZINC ION, 6-amino-2-(methylamino)-4-(4-(trifluoromethyl)phenethyl)-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
Authors:Nguyen, A., Heine, A., Klebe, G.
Deposit date:2020-03-28
Release date:2020-04-08
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Co-crystallization, nanoESI-MS and 19F NMR reveal dimer disturbing inhibitors and conformational changes at dimer contacts
To Be Published
6YH2
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TRNA-GUANINE TRANSGLYCOSYLASE (TGT) LABELED WITH 5-FLUOROTRYPTOPHAN IN CO-CRYSTALLIZED COMPLEX WITH 2-(METHYLAMINO)-1,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE
Descriptor:Queuine tRNA-ribosyltransferase, ZINC ION, GLYCEROL, ...
Authors:Nguyen, A., Heine, A., Klebe, G.
Deposit date:2020-03-28
Release date:2020-04-08
Method:X-RAY DIFFRACTION (1.19 Å)
Cite:Co-crystallization, nanoESI-MS and 19F NMR reveal dimer disturbing inhibitors and conformational changes at dimer contacts
To Be Published
6YH3
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TRNA-GUANINE TRANSGLYCOSYLASE (TGT) IN CO-CRYSTALLIZED COMPLEX WITH 6-AMINO-2-(METHYLAMINO)-4-PHENETHYL-1,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE
Descriptor:Queuine tRNA-ribosyltransferase, ZINC ION, 6-amino-2-(methylamino)-4-phenethyl-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one
Authors:Nguyen, A., Heine, A., Klebe, G.
Deposit date:2020-03-28
Release date:2020-04-08
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Co-crystallization, 19F NMR and nanoESI-MS reveal dimer disturbing inhibitors and conformational changes at dimer contacts
To Be Published
6YHD
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TRNA-GUANINE TRANSGLYCOSYLASE (TGT) LABELED WITH 5-FLUOROTRYPTOPHAN IN CO-CRYSTALLIZED COMPLEX WITH 6-AMINO-4-(2-((2R,3S,4R,5R)-3,4-DIHYDROXY-5-METHOXYTETRAHYDROFURAN-2-YL)ETHYL)-2-(METHYLAMINO)-3,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE
Descriptor:Queuine tRNA-ribosyltransferase, methyl 6-[6-amino-2-(methylamino)-8-oxo-7,8-dihydro-1H-imidazo[4,5-g]quinazolin-4-yl]-5,6-dideoxy-beta-D-ribo-hexofuranoside, GLYCEROL, ...
Authors:Nguyen, A., Heine, A., Klebe, G.
Deposit date:2020-03-28
Release date:2020-04-08
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Co-crystallization, nanoESI-MS and 19F NMR reveal dimer disturbing inhibitors and conformational changes at dimer contacts
To Be Published
6YGK
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TGT Y330F MUTANT CRYSTALLISED AT PH 8.5
Descriptor:Queuine tRNA-ribosyltransferase, GLYCEROL, ZINC ION
Authors:Nguyen, A., Heine, A., Klebe, G.
Deposit date:2020-03-27
Release date:2020-04-08
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Mutation study on tRNA-guanine transglycosylase for catalysis Testing
To Be Published
6YGL
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TGT W326F MUTANT LABELLED MIT 5F-TRP CRYSTALLISED AT PH 5.5
Descriptor:Queuine tRNA-ribosyltransferase, GLYCEROL, ZINC ION, ...
Authors:Nguyen, A., Heine, A., Klebe, G.
Deposit date:2020-03-27
Release date:2020-04-08
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Mutation study on tRNA-guanine transglycosylase within 19F NMR experiments for conformational change analysis
To Be Published
6YGM
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TGT W95F MUTANT LABELLED MIT 5F-TRP CRYSTALLISED AT PH 5.5
Descriptor:Queuine tRNA-ribosyltransferase, ZINC ION
Authors:Nguyen, A., Heine, A., Klebe, G.
Deposit date:2020-03-27
Release date:2020-04-08
Method:X-RAY DIFFRACTION (1.23 Å)
Cite:Mutation study on tRNA-guanine transglycosylase within 19F NMR experiments for conformational change analysis
To Be Published
6YGO
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TGT W95F MUTANT LABELLED MIT 5F-TRP CRYSTALLISED AT PH 8.5
Descriptor:Queuine tRNA-ribosyltransferase, ZINC ION, GLYCEROL
Authors:Nguyen, A., Heine, A., Klebe, G.
Deposit date:2020-03-27
Release date:2020-04-08
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Mutation study on tRNA-guanine transglycosylase within 19F NMR experiments for conformational change analysis
To Be Published
6YGP
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TGT WT LABELLED MIT 5F-TRP CRYSTALLISED AT PH 5.5
Descriptor:Queuine tRNA-ribosyltransferase, GLYCEROL, ZINC ION, ...
Authors:Nguyen, A., Heine, A., Klebe, G.
Deposit date:2020-03-27
Release date:2020-04-08
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:Mutation study on tRNA-guanine transglycosylase within 19F NMR experiments for conformational change analysis
To Be Published
6YGR
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TRNA-GUANINE TRANSGLYCOSYLASE (TGT) IN CO-CRYSTALLIZED COMPLEX WITH 6-AMINO-4-(2-PHENYLETHYL)-1,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE
Descriptor:Queuine tRNA-ribosyltransferase, ZINC ION, 6-AMINO-4-(2-PHENYLETHYL)-1,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE
Authors:Nguyen, A., Heine, A., Klebe, G.
Deposit date:2020-03-27
Release date:2020-04-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Co-crystallization and nanoESI-MS reveal dimer disturbing inhibitors and conformational changes at dimer contacts
To Be Published
6YGS
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TRNA-GUANINE TRANSGLYCOSYLASE (TGT) IN CO-CRYSTALLIZED COMPLEX WITH 6-AMINO-2-(METHYLAMINO)-4-(4-(TRIFLUOROMETHYL)PHENETHYL)-3,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE
Descriptor:Queuine tRNA-ribosyltransferase, ZINC ION, 6-amino-2-(methylamino)-4-(4-(trifluoromethyl)phenethyl)-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, ...
Authors:Nguyen, A., Heine, A., Klebe, G.
Deposit date:2020-03-27
Release date:2020-04-08
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Co-crystallization and 19F NMR reveal dimer disturbing inhibitors and conformational changes at dimer contacts
To Be Published
6YGV
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TRNA-GUANINE TRANSGLYCOSYLASE (TGT) IN CO-CRYSTALLIZED COMPLEX WITH (E)-N-ETHYL-4-OXO-4-PHENYLBUT-2-ENAMIDE
Descriptor:Queuine tRNA-ribosyltransferase, GLYCEROL, ZINC ION, ...
Authors:Nguyen, A., Heine, A., Klebe, G.
Deposit date:2020-03-27
Release date:2020-04-08
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Ligands disturb dimer contacts
To Be Published
6YGW
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TGT W178F MUTANT LABELLED MIT 5F-TRP CRYSTALLISED AT PH 5.5
Descriptor:Queuine tRNA-ribosyltransferase, GLYCEROL, ZINC ION, ...
Authors:Nguyen, A., Heine, A., Klebe, G.
Deposit date:2020-03-27
Release date:2020-04-08
Method:X-RAY DIFFRACTION (1.16 Å)
Cite:Mutation study on tRNA-guanine transglycosylase within 19F NMR experiments for conformational change analysis
To Be Published
6YGX
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TRNA-GUANINE TRANSGLYCOSYLASE (TGT) LABELED WITH 5-FLUOROTRYPTOPHAN IN CO-CRYSTALLIZED COMPLEX WITH 6-AMINO-2-(METHYLAMINO)-4-(2-((2R,3R,4S,5R,6S)-3,4,5,6-TETRAMETHOXYTETRAHYDRO-2H-PYRAN-2-YL)ETHYL)-1H-IMIDAZO[4,5-G]QUINAZOLIN-8(7H)-ONE
Descriptor:Queuine tRNA-ribosyltransferase, ZINC ION, 6-azanyl-2-(methylamino)-4-[2-[(2~{R},3~{R},4~{S},5~{R},6~{S})-3,4,5,6-tetramethoxyoxan-2-yl]ethyl]-1,7-dihydroimidazo[4,5-g]quinazolin-8-one
Authors:Nguyen, A., Heine, A., Klebe, G.
Deposit date:2020-03-27
Release date:2020-04-08
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Co-crystallization, nanoESI-MS and 19F NMR reveal dimer disturbing inhibitors and conformational changes at dimer contacts
To Be Published
6WBD
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CRYSTAL STRUCTURE OF LYSYL-TRNA SYNTHETASE FROM STENOTROPHOMONAS MALTOPHILIA WITH BOUND L-LYSINE
Descriptor:Lysine--tRNA ligase, LYSINE, 1,2-ETHANEDIOL, ...
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2020-03-26
Release date:2020-04-08
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal Structure of Lysyl-tRNA synthetase from Stenotrophomonas maltophilia with bound L-lysine
to be published
6YFW
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TGT H333F MUTANT CRYSTALLISED AT PH 8.5
Descriptor:Queuine tRNA-ribosyltransferase, ZINC ION, GLYCEROL, ...
Authors:Nguyen, A., Heine, A., Klebe, G.
Deposit date:2020-03-26
Release date:2020-04-08
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Mutation study on tRNA-guanine transglycosylase for catalysis Testing
To Be Published