Mine: Advanced search results

Advanced query:
Add keyword:
Search
Go to Advanced search
6O3I
  • Download 6o3i
  • View 6o3i
Molmil generated image of 6o3i
CRYSTAL STRUCTURE OF HUMAN IDO1 BOUND TO NAVOXIMOD (NLG-919)
Descriptor:Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, trans-4-{(1R)-2-[(5S)-6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl]-1-hydroxyethyl}cyclohexan-1-ol
Authors:Harris, S.F., Oh, A.
Deposit date:2019-02-26
Release date:2019-07-17
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Discovery of Clinical Candidate (1 R,4 r)-4-(( R)-2-(( S)-6-Fluoro-5 H-imidazo[5,1- a]isoindol-5-yl)-1-hydroxyethyl)cyclohexan-1-ol (Navoximod), a Potent and Selective Inhibitor of Indoleamine 2,3-Dioxygenase 1.
J.Med.Chem., 2019
6OD9
  • Download 6od9
  • View 6od9
Molmil generated image of 6od9
CO-CRYSTAL STRUCTURE OF THE FUSOBACTERIUM ULCERANS ZTP RIBOSWITCH USING AN X-RAY FREE-ELECTRON LASER
Descriptor:RNA (75-MER), MAGNESIUM ION, AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, ...
Authors:Jones, C.P., Tran, B., Ferre-D'Amare, A.R.
Deposit date:2019-03-26
Release date:2019-07-17
Method:X-RAY DIFFRACTION (4.102 Å)
Cite:Co-crystal structure of the Fusobacterium ulcerans ZTP riboswitch using an X-ray free-electron laser
Acta Crystallogr.,Sect.F, 2019
6OKO
  • Download 6oko
  • View 6oko
Molmil generated image of 6oko
CRYSTAL STRUCTURE OF MRIPK3 COMPLEXED WITH N-(3-FLUORO-4-{1H-PYRROLO[2,3-B]PYRIDIN-4-YLOXY}PHENYL)-1-(4-FLUOROPHENYL)-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE
Descriptor:Receptor-interacting serine/threonine-protein kinase 3, 1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide
Authors:Pokross, M.E.
Deposit date:2019-04-14
Release date:2019-07-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Identification of RIPK3 Type II Inhibitors Using High-Throughput Mechanistic Studies in Hit Triage
Acs Med.Chem.Lett., 2019
6OMB
  • Download 6omb
  • View 6omb
Molmil generated image of 6omb
CDC48 HEXAMER (SUBUNITS A TO E) WITH SUBSTRATE BOUND TO THE CENTRAL PORE
Descriptor:Cell division control protein 48, Substrate of Cdc48, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Cooney, I., Han, H., Stewart, M., Carson, R.H., Hansen, D., Price, J.C., Hill, C.P., Shen, P.S.
Deposit date:2019-04-18
Release date:2019-07-17
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structure of the Cdc48 segregase in the act of unfolding an authentic substrate.
Science, 2019
6OOR
  • Download 6oor
  • View 6oor
Molmil generated image of 6oor
STRUCTURE OF 1B1 BOUND TO MOUSE CD1D
Descriptor:Antigen-presenting glycoprotein CD1d1, Beta-2-microglobulin, Antibody 1B1 Light chain, ...
Authors:Ying, G., Zajonc, D.M.
Deposit date:2019-04-23
Release date:2019-07-17
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural basis of NKT cell inhibition using the T-cell receptor-blocking anti-CD1d antibody 1B1
J.Biol.Chem., 2019
6OS3
  • Download 6os3
  • View 6os3
Molmil generated image of 6os3
CRYSTAL STRUCTURE OF NATIVE CYMD PRENYLTRANSFERASE
Descriptor:CymD prenyltransferase, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Roose, B.W., Christianson, D.W.
Deposit date:2019-05-01
Release date:2019-07-17
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Basis of Tryptophan Reverse N-Prenylation Catalyzed by CymD.
Biochemistry, 2019
6OS5
  • Download 6os5
  • View 6os5
Molmil generated image of 6os5
CRYSTAL STRUCTURE OF CYMD PRENYLTRANSFERASE COMPLEXED WITH L-TRYPTOPHAN
Descriptor:CymD prenyltransferase, TRYPTOPHAN, BENZOIC ACID, ...
Authors:Roose, B.W., Christianson, D.W.
Deposit date:2019-05-01
Release date:2019-07-17
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Structural Basis of Tryptophan Reverse N-Prenylation Catalyzed by CymD.
Biochemistry, 2019
6OS6
  • Download 6os6
  • View 6os6
Molmil generated image of 6os6
CRYSTAL STRUCTURE OF CYMD PRENYLTRANSFERASE COMPLEXED WITH L-TRYPTOPHAN AND DMSPP
Descriptor:CymD prenyltransferase, S-(3-methylbut-2-en-1-yl) trihydrogen thiodiphosphate, TRYPTOPHAN, ...
Authors:Roose, B.W., Christianson, D.W.
Deposit date:2019-05-01
Release date:2019-07-17
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:Structural Basis of Tryptophan Reverse N-Prenylation Catalyzed by CymD.
Biochemistry, 2019
6P9F
  • Download 6p9f
  • View 6p9f
Molmil generated image of 6p9f
CRYSTAL STRUCTURE OF RAR-RELATED ORPHAN RECEPTOR C (NHIS-RORGT(244-487)-L6-SRC1(678-692)) IN COMPLEX WITH A PHENYL (3-PHENYLPYRROLIDIN-3-YL)SULFONE INHIBITOR
Descriptor:Nuclear receptor ROR-gamma, Nuclear receptor coactivator 1 chimera, trans-4-{(3R)-3-[(4-fluorophenyl)sulfonyl]-3-[4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)phenyl]pyrrolidine-1-carbonyl}cyclohexane-1-carboxylic acid
Authors:Sack, J.
Deposit date:2019-06-10
Release date:2019-07-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as ROR gamma t inverse agonists.
Bioorg.Med.Chem.Lett., 2019
6PET
  • Download 6pet
  • View 6pet
Molmil generated image of 6pet
CRYSTAL STRUCTURE OF 8-HYDROXYCHROMENE COMPOUND 30 BOUND TO ESTROGEN RECEPTOR ALPHA
Descriptor:Estrogen receptor, (2S)-3-(3-hydroxyphenyl)-2-(4-iodophenyl)-4-methyl-2H-1-benzopyran-6-ol, (2S)-2-(4-{2-[3-(fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-3-(3-hydroxyphenyl)-4-methyl-2H-1-benzopyran-8-ol, ...
Authors:Kiefer, J.R., Vinogradova, M., Liang, J., Wang, X., Zbieg, J., Labadie, S.S., Zhang, B., Li, J., Liang, W.
Deposit date:2019-06-20
Release date:2019-07-17
Method:X-RAY DIFFRACTION (2.203 Å)
Cite:Discovery of a C-8 Hydroxychromene as a Potent Degrader of Estrogen Receptor alpha with Improved Rat Oral Exposure over GDC-0927
Bioorg.Med.Chem.Lett., 2019
6PFM
  • Download 6pfm
  • View 6pfm
Molmil generated image of 6pfm
CRYSTAL STRUCTURE OF GDC-0927 BOUND TO ESTROGEN RECEPTOR ALPHA
Descriptor:Estrogen receptor, (2S)-2-(4-{2-[3-(fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-3-(3-hydroxyphenyl)-4-methyl-2H-1-benzopyran-6-ol
Authors:Kiefer, J.R., Vinogradova, M., Liang, J., Zhang, B., Wang, X., Zbieg, J.R., Labadie, S.S., Li, J., Ray, N.C., Ortwine, D.
Deposit date:2019-06-21
Release date:2019-07-17
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Discovery of a C-8 Hydroxychromene as a Potent Degrader of Estrogen Receptor alpha with Improved Rat Oral Exposure over GDC-0927
Bioorg.Med.Chem.Lett., 2019
6PNV
  • Download 6pnv
  • View 6pnv
Molmil generated image of 6pnv
1.42 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF TRANSLOCATION PROTEIN TOLB FROM SALMONELLA ENTERICA
Descriptor:Tol-Pal system protein TolB, POTASSIUM ION, SODIUM ION
Authors:Minasov, G., Shuvalova, L., Dubrovska, I., Kiryukhina, O., Endres, M., Satchell, K.J.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2019-07-03
Release date:2019-07-17
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:1.42 Angstrom Resolution Crystal Structure of Translocation Protein TolB from Salmonella enterica
To Be Published
6PO4
  • Download 6po4
  • View 6po4
Molmil generated image of 6po4
2.1 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF 5'-METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE (MTNN) FROM HAEMOPHILUS INFLUENZAE PITTII.
Descriptor:5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, 2-AMINO-4-MERCAPTO-BUTYRIC ACID, ADENINE, ...
Authors:Minasov, G., Shuvalova, L., Cardona-Correa, A., Dubrovska, I., Grimshaw, S., Kwon, K., Satchell, K.J.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2019-07-03
Release date:2019-07-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:2.1 Angstrom Resolution Crystal Structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (mtnN) from Haemophilus influenzae PittII.
To Be Published
6QH3
  • Download 6qh3
  • View 6qh3
Molmil generated image of 6qh3
CATALYTIC DOMAIN OF THE HUMAN UBIQUITIN-CONJUGATING ENZYME UBE2S C118M
Descriptor:Ubiquitin-conjugating enzyme E2 S, 1,2-ETHANEDIOL
Authors:Liess, A.K.L., Lorenz, S.
Deposit date:2019-01-15
Release date:2019-07-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Autoinhibition Mechanism of the Ubiquitin-Conjugating Enzyme UBE2S by Autoubiquitination.
Structure, 2019
6QHK
  • Download 6qhk
  • View 6qhk
Molmil generated image of 6qhk
PAO-LINKED DIMER OF THE CATALYTIC DOMAIN OF THE HUMAN UBIQUITIN-CONJUGATING ENZYME UBE2S
Descriptor:Ubiquitin-conjugating enzyme E2 S, CHLORIDE ION, 1,2-ETHANEDIOL, ...
Authors:Liess, A.K.L., Lorenz, S.
Deposit date:2019-01-16
Release date:2019-07-17
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Autoinhibition Mechanism of the Ubiquitin-Conjugating Enzyme UBE2S by Autoubiquitination.
Structure, 2019
6QI4
  • Download 6qi4
  • View 6qi4
Molmil generated image of 6qi4
NCS-1 BOUND TO A LIGAND
Descriptor:Neuronal calcium sensor 1, CALCIUM ION, HEXAETHYLENE GLYCOL, ...
Authors:Sanchez-Barrena, M.J., Blanco-Gabella, P.
Deposit date:2019-01-17
Release date:2019-07-17
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library.
Nat Commun, 10, 2019
6QK7
  • Download 6qk7
  • View 6qk7
Molmil generated image of 6qk7
ELONGATOR CATALYTIC SUBCOMPLEX ELP123 LOBE
Descriptor:Elongator complex protein 1, Elongator complex protein 2, Elongator complex protein 3, ...
Authors:Dauden, M.I., Jaciuk, M., Glatt, S.
Deposit date:2019-01-28
Release date:2019-07-17
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Molecular basis of tRNA recognition by the Elongator complex
Sci Adv, 2019
6QKP
  • Download 6qkp
  • View 6qkp
Molmil generated image of 6qkp
NMR SOLUTION STRUCTURE OF LSR2 BINDING DOMAIN.
Descriptor:Nucleoid-associated protein Lsr2
Authors:Barthe, P., Cohen-Gonsaud, M., Mukamolova, G.V.
Deposit date:2019-01-30
Release date:2019-07-17
Method:SOLUTION NMR
Cite:Protein kinase B controls Mycobacterium tuberculosis growth via phosphorylation of the global transcriptional regulator Lsr2.
To Be Published
6QKQ
  • Download 6qkq
  • View 6qkq
Molmil generated image of 6qkq
NMR SOLUTION STRUCTURE OF LSR2-T112D BINDING DOMAIN.
Descriptor:Nucleoid-associated protein Lsr2
Authors:Barthe, P., Cohen-Gonsaud, M., Mukamolova, G.V.
Deposit date:2019-01-30
Release date:2019-07-17
Method:SOLUTION NMR
Cite:Protein kinase B controls Mycobacterium tuberculosis growth via phosphorylation of the global transcriptional regulator Lsr2.
To Be Published
6QPL
  • Download 6qpl
  • View 6qpl
Molmil generated image of 6qpl
CRYSTAL STRUCTURE OF SPINDLIN1 IN COMPLEX WITH THE INHIBITOR MS31
Descriptor:Spindlin-1, (4S)-2-METHYL-2,4-PENTANEDIOL, DIMETHYL SULFOXIDE, ...
Authors:Johansson, C., Krojer, T., Xiong, Y., Jin, J., Arrowsmith, C.H., Bountra, C., Edwards, A., Oppermann, U.C.T.
Deposit date:2019-02-14
Release date:2019-07-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1).
J.Med.Chem., 2019
6QRR
  • Download 6qrr
  • View 6qrr
Molmil generated image of 6qrr
X-RAY RADIATION DOSE SERIES ON XYLOSE ISOMERASE - 0.13 MGY
Descriptor:Xylose isomerase, 1,2-ETHANEDIOL, ISOPROPYL ALCOHOL, ...
Authors:Taberman, H., Bury, C.S., van der Woerd, M.J., Snell, E.H., Garman, E.F.
Deposit date:2019-02-19
Release date:2019-07-17
Method:X-RAY DIFFRACTION (1.096 Å)
Cite:Structural knowledge or X-ray damage? A case study on xylose isomerase illustrating both.
J.Synchrotron Radiat., 26, 2019
6QRS
  • Download 6qrs
  • View 6qrs
Molmil generated image of 6qrs
X-RAY RADIATION DOSE SERIES ON XYLOSE ISOMERASE - 0.13 MGY
Descriptor:Xylose isomerase, 1,2-ETHANEDIOL, ISOPROPYL ALCOHOL, ...
Authors:Taberman, H., Bury, C.S., van der Woerd, M.J., Snell, E.H., Garman, E.F.
Deposit date:2019-02-19
Release date:2019-07-17
Method:X-RAY DIFFRACTION (1.17 Å)
Cite:Structural knowledge or X-ray damage? A case study on xylose isomerase illustrating both.
J.Synchrotron Radiat., 26, 2019
6QRT
  • Download 6qrt
  • View 6qrt
Molmil generated image of 6qrt
X-RAY RADIATION DOSE SERIES ON XYLOSE ISOMERASE - 1.38 MGY
Descriptor:Xylose isomerase, 1,2-ETHANEDIOL, ISOPROPYL ALCOHOL, ...
Authors:Taberman, H., Bury, C.S., van der Woerd, M.J., Snell, E.H., Garman, E.F.
Deposit date:2019-02-19
Release date:2019-07-17
Method:X-RAY DIFFRACTION (1.17 Å)
Cite:Structural knowledge or X-ray damage? A case study on xylose isomerase illustrating both.
J.Synchrotron Radiat., 26, 2019
6QRU
  • Download 6qru
  • View 6qru
Molmil generated image of 6qru
X-RAY RADIATION DOSE SERIES ON XYLOSE ISOMERASE - 2.01 MGY
Descriptor:Xylose isomerase, 1,2-ETHANEDIOL, ISOPROPYL ALCOHOL, ...
Authors:Taberman, H., Bury, C.S., van der Woerd, M.J., Snell, E.H., Garman, E.F.
Deposit date:2019-02-19
Release date:2019-07-17
Method:X-RAY DIFFRACTION (1.17 Å)
Cite:Structural knowledge or X-ray damage? A case study on xylose isomerase illustrating both.
J.Synchrotron Radiat., 26, 2019
6QRV
  • Download 6qrv
  • View 6qrv
Molmil generated image of 6qrv
X-RAY RADIATION DOSE SERIES ON XYLOSE ISOMERASE - 2.63 MGY
Descriptor:Xylose isomerase, 1,2-ETHANEDIOL, ISOPROPYL ALCOHOL, ...
Authors:Taberman, H., Bury, C.S., van der Woerd, M.J., Snell, E.H., Garman, E.F.
Deposit date:2019-02-19
Release date:2019-07-17
Method:X-RAY DIFFRACTION (1.17 Å)
Cite:Structural knowledge or X-ray damage? A case study on xylose isomerase illustrating both.
J.Synchrotron Radiat., 26, 2019