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6I29
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X-RAY STRUCTURE OF THE P53-MDM2 INHIBITOR NMI801 BOUND TO HDM2 AT 2.1A RESOLUTION
Descriptor:Human E3 Ubiquitin-Protein Ligase MDM2, 6-chloranyl-3-[3-[(1~{S})-1-(4-chlorophenyl)ethyl]-5-phenyl-imidazol-4-yl]-~{N}-[2-[4-(2-oxidanylidene-1,3-oxazinan-3-yl)piperidin-1-yl]pyridin-3-yl]-1~{H}-indole-2-carboxamide
Authors:Kallen, J.
Deposit date:2018-11-01
Release date:2019-11-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:p53 dynamics vary between tissues and are linked with radiation sensitivity
To be published
6I2F
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HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH 4-PROPOXYBENZENESULFONAMIDE
Descriptor:Carbonic anhydrase 2, ZINC ION, MERCURY (II) ION, ...
Authors:Gloeckner, S., Heine, A., Klebe, G.
Deposit date:2018-11-01
Release date:2019-11-20
Method:X-RAY DIFFRACTION (1.198 Å)
Cite:Human Carbonic Anhydrase II in complex with 4-Propoxybenzenesulfonamide
To Be Published
6I2H
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CRYSTAL STRUCTURE OF THE PROTEIN-KINASE A CATALYTIC SUBUNIT FROM CRICETULUS GRISEUS IN COMPLEX WITH COMPOUNDS RKP182 AND RKP190
Descriptor:cAMP-dependent protein kinase catalytic subunit alpha, UPF0418 protein FAM164A, [2-[[2-(isoquinolin-5-ylsulfonylamino)ethylamino]methyl]phenyl]boronic acid, ...
Authors:Mueller, J.M., Heine, A., Klebe, G.
Deposit date:2018-11-01
Release date:2019-11-20
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Crystal Structure of the Protein-Kinase A catalytic subunit from Cricetulus Griseus in complex with compounds RKp182 and RKp190
To be published
6I33
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CRYSTAL STRUCTURE OF HUMAN GLYCINE DECARBOXYLASE (P-PROTEIN)
Descriptor:Glycine dehydrogenase (decarboxylating), mitochondrial, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Van Laer, B., Kapp, U., Leonard, G., Mueller-Dieckmann, C.
Deposit date:2018-11-05
Release date:2019-11-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insights in human glycine decarboxylase and comparison with the Neanderthal variant
To Be Published
6I34
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CRYSTAL STRUCTURE OF NEANDERTHAL GLYCINE DECARBOXYLASE (P-PROTEIN)
Descriptor:Neanderthal Glycine decarboxylase, PYRIDOXAL-5'-PHOSPHATE, 1,2-ETHANEDIOL, ...
Authors:Van Laer, B., Kapp, U., Leonard, G., Mueller-Dieckmann, C.
Deposit date:2018-11-05
Release date:2019-11-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural insights in human glycine decarboxylase and comparison with the Neanderthal variant
To Be Published
6I35
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CRYSTAL STRUCTURE OF HUMAN GLYCINE DECARBOXYLASE (P-PROTEIN) BOUND WITH PYRIDOXYL-GLYCINE-5'-MONOPHOSPHATE
Descriptor:Glycine dehydrogenase (decarboxylating), mitochondrial, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], ...
Authors:Van Laer, B., Kapp, U., Leonard, G., Mueller-Dieckmann, C.
Deposit date:2018-11-05
Release date:2019-11-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural insights in human glycine decarboxylase and comparison with the Neanderthal variant
To Be Published
6I37
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CRYSTAL STRUCTURE OF NV1PIZZA6-AYW, A CIRCULARLY PERMUTED DESIGNER PROTEIN
Descriptor:nv1Pizza6-AYW, SULFATE ION
Authors:Mylemans, B., Noguchi, H., Deridder, E., Voet, A.R.D.
Deposit date:2018-11-05
Release date:2019-11-20
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Circularization and circular permutations of the symmetric designer protein Pizza6-AYW
To Be Published
6I38
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CRYSTAL STRUCTURE OF NV2PIZZA6-AYW, A CIRCULARLY PERMUTED DESIGNER PROTEIN
Descriptor:nv2Pizza6-AYW
Authors:Mylemans, B., Noguchi, H., Deridder, E., Voet, A.R.D.
Deposit date:2018-11-05
Release date:2019-11-20
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Circularization and circular permutations of the symmetric designer protein Pizza6-AYW
To Be Published
6I39
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CRYSTAL STRUCTURE OF V13PIZZA6-AYW, A CIRCULARLY PERMUTED DESIGNER PROTEIN
Descriptor:v13Pizza6-AYW, MAGNESIUM ION
Authors:Mylemans, B., Noguchi, H., Deridder, E., Voet, A.R.D.
Deposit date:2018-11-05
Release date:2019-11-20
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Circularization and circular permutations of the symmetric designer protein Pizza6-AYW
To Be Published
6I3A
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CRYSTAL STRUCTURE OF V22PIZZA6-AYW, A CIRCULARLY PERMUTED DESIGNER PROTEIN
Descriptor:v22Pizza6-AYW, BROMIDE ION
Authors:Mylemans, B., Noguchi, H., Deridder, E., Voet, A.R.D.
Deposit date:2018-11-05
Release date:2019-11-20
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Circularization and circular permutations of the symmetric designer protein Pizza6-AYW
To Be Published
6I3B
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CRYSTAL STRUCTURE OF CPIZZA6-AYW, A CIRCULARLY PERMUTED DESIGNER PROTEIN
Descriptor:cPizza6-AYW
Authors:Mylemans, B., Noguchi, H., Deridder, E., Voet, A.R.D.
Deposit date:2018-11-05
Release date:2019-11-20
Method:X-RAY DIFFRACTION (1 Å)
Cite:Circularization and circular permutations of the symmetric designer protein Pizza6-AYW
To Be Published
6I3E
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HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH 4-BUTYLBENZENESULFONAMIDE
Descriptor:Carbonic anhydrase 2, ZINC ION, DIMETHYL SULFOXIDE, ...
Authors:Gloeckner, S., Ngo, K., Heine, A., Klebe, G.
Deposit date:2018-11-05
Release date:2019-11-20
Method:X-RAY DIFFRACTION (1.07 Å)
Cite:Human Carbonic Anhydrase II in complex with 4-Butylbenzenesulfonamide
To Be Published
6I3N
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HELICAL MYD88 DEATH DOMAIN FILAMENT
Descriptor:Myeloid differentiation primary response protein MyD88
Authors:Moncrieffe, M.C., Bollschweiler, D., Penczek, P.A.P., Gay, N.J.
Deposit date:2018-11-06
Release date:2019-11-20
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Death domain filaments in TLR signaling
To Be Published
6I3Z
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FAB FRAGMENT OF AN ANTIBODY SELECTIVE FOR WILD-TYPE ALPHA-1-ANTITRYPSIN IN COMPLEX WITH ITS ANTIGEN
Descriptor:Alpha-1-antitrypsin, Fab 2H2 heavy chain, Fab 2H2 light chain, ...
Authors:Laffranchi, M., Elliston, E.L.K., Miranda, E., Perez, J., Jagger, A.M., Fra, A., Lomas, D.A., Irving, J.A.
Deposit date:2018-11-08
Release date:2019-11-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Characterisation of polymers extracted from the liver tissue of individuals with the MZ alpha-1-antitrypsin deficiency genotype
To Be Published
6I4P
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CRYSTAL STRUCTURE OF THE DISEASE-CAUSING G194C MUTANT OF THE HUMAN DIHYDROLIPOAMIDE DEHYDROGENASE
Descriptor:Dihydrolipoyl dehydrogenase, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Szabo, E., Wilk, P., Torocsik, B., Weiss, M.S., Adam-Vizi, V., Ambrus, A.
Deposit date:2018-11-10
Release date:2019-11-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Underlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants.
Hum.Mol.Genet., 2019
6I4Q
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CRYSTAL STRUCTURE OF THE HUMAN DIHYDROLIPOAMIDE DEHYDROGENASE AT 1.75 ANGSTROM RESOLUTION
Descriptor:Dihydrolipoyl dehydrogenase, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Nagy, B., Szabo, E., Wilk, P., Torocsik, B., Weiss, M.S., Adam-Vizi, V., Ambrus, A.
Deposit date:2018-11-10
Release date:2019-11-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Underlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants.
Hum.Mol.Genet., 2019
6I4R
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CRYSTAL STRUCTURE OF THE DISEASE-CAUSING R460G MUTANT OF THE HUMAN DIHYDROLIPOAMIDE DEHYDROGENASE AT 1.44 ANGSTROM RESOLUTION
Descriptor:Dihydrolipoyl dehydrogenase, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Szabo, E., Wilk, P., Bui, D., Torocsik, B., Weiss, M.S., Adam-Vizi, V., Ambrus, A.
Deposit date:2018-11-10
Release date:2019-11-20
Method:X-RAY DIFFRACTION (1.439 Å)
Cite:Underlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants.
Hum.Mol.Genet., 2019
6I4S
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CRYSTAL STRUCTURE OF THE DISEASE-CAUSING R447G MUTANT OF THE HUMAN DIHYDROLIPOAMIDE DEHYDROGENASE
Descriptor:Dihydrolipoyl dehydrogenase, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Szabo, E., Wilk, P., Hubert, A., Torocsik, B., Weiss, M.S., Adam-Vizi, V., Ambrus, A.
Deposit date:2018-11-10
Release date:2019-11-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Underlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants.
Hum.Mol.Genet., 2019
6I4T
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CRYSTAL STRUCTURE OF THE DISEASE-CAUSING I445M MUTANT OF THE HUMAN DIHYDROLIPOAMIDE DEHYDROGENASE
Descriptor:Dihydrolipoyl dehydrogenase, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Szabo, E., Wilk, P., Zambo, Z., Torocsik, B., Weiss, M.S., Adam-Vizi, V., Ambrus, A.
Deposit date:2018-11-10
Release date:2019-11-20
Method:X-RAY DIFFRACTION (1.823 Å)
Cite:Underlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants.
Hum.Mol.Genet., 2019
6I4U
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CRYSTAL STRUCTURE OF THE DISEASE-CAUSING G426E MUTANT OF THE HUMAN DIHYDROLIPOAMIDE DEHYDROGENASE
Descriptor:Dihydrolipoyl dehydrogenase, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Szabo, E., Wilk, P., Hubert, A., Torocsik, B., Weiss, M.S., Adam-Vizi, V., Ambrus, A.
Deposit date:2018-11-10
Release date:2019-11-20
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Underlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants.
Hum.Mol.Genet., 2019
6I4V
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ALPHA-1-ANTITRYPSIN QUEEN'S (K154N) VARIANT
Descriptor:Alpha-1-antitrypsin, GLYCINE, 3-trimethylsilylpropane-1-sulfonic acid
Authors:Aldobiyan, I., Lomas, D.A., Irving, J.A.
Deposit date:2018-11-12
Release date:2019-11-20
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural determinants of instability in alpha-1-antitrypsin
To Be Published
6I4Z
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CRYSTAL STRUCTURE OF THE DISEASE-CAUSING P453L MUTANT OF THE HUMAN DIHYDROLIPOAMIDE DEHYDROGENASE
Descriptor:Dihydrolipoyl dehydrogenase, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Szabo, E., Wilk, P., Torocsik, B., Weiss, M.S., Adam-Vizi, V., Ambrus, A.
Deposit date:2018-11-12
Release date:2019-11-20
Method:X-RAY DIFFRACTION (2.342 Å)
Cite:Underlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants.
Hum.Mol.Genet., 2019
6I51
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THROMBIN IN COMPLEX WITH FRAGMENT J02
Descriptor:Prothrombin, Hirudin variant-2, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Abazi, N., Heine, A., Klebe, G.
Deposit date:2018-11-12
Release date:2019-11-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Fragment screening of Thrombin using a 96 member fragment library
To Be Published
6I56
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CRYSTAL STRUCTURE OF PBSX EXPORTED PROTEIN XEPA
Descriptor:Phage-like element PBSX protein XepA, GLYCEROL
Authors:Hakansson, H., Svensson, L.A., Welin, M., Al-Karadaghi, S.
Deposit date:2018-11-13
Release date:2019-11-20
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Crystal structures of the Bacillus subtilis prophage lytic cassette proteins XepA and YomS.
Acta Crystallogr D Struct Biol, 75, 2019
6I5O
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CRYSTAL STRUCTURE OF SPBC2 PROPHAGE-DERIVED PROTEIN YOMS
Descriptor:SPBc2 prophage-derived uncharacterized protein YomS
Authors:Hakansson, H., Svensson, L.A., Welin, M., Al-Karadaghi, S.
Deposit date:2018-11-14
Release date:2019-11-20
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:Crystal structures of the Bacillus subtilis prophage lytic cassette proteins XepA and YomS
Acta Crystallogr.,Sect.D, 2019