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6ZWV
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CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE PROTEINS ON INTACT VIRIONS: 3 CLOSED RBDS
分子名称:Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose
著者Ke, Z., Qu, K., Nakane, T., Xiong, X., Cortese, M., Zila, V., Scheres, S.H.W., Briggs, J.A.G.
登録日2020-07-28
公開日2020-08-05
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structures and distributions of SARS-CoV-2 spike proteins on intact virions
To Be Published
7JJL
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CRYSTAL STRUCTURE OF IMPORTIN ALPHA 3 IN COMPLEX WITH HUMAN LSD1 NLS
分子名称:Importin subunit alpha-3, Lysine-specific histone demethylase 1A
著者Tu, W.J., McCuaig, R., Tan, H.Y.A., Hardy, K., Seddiki, N., Ali, S., Dahlstrom, J.E., Bean, E.G., Dunn, J., Forwood, J.K., Tsimbalyuk, S., Smith, K., Yip, D., Malik, L., Prasana, T., Milburn, P., Rao, S.
登録日2020-07-27
公開日2020-08-05
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch.
Front Immunol, 11, 2020
7JJM
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CRYSTAL STRUCTURE OF IMPORTIN ALPHA 2 IN COMPLEX WITH LSD1 NLS
分子名称:Lysine-specific histone demethylase 1A, Importin subunit alpha-1, CHLORIDE ION
著者Tu, W.J., McGuaig, R., Tan, H.Y.A., Hardy, C., Seddiki, N., Ali, S., Dahlstrom, J.E., Bean, E.G., Dunn, J., Forwood, J.K., Tsimbalyuk, S., Smith, K.M., Yip, D., Malik, L., Prasana, T., Milburn, P., Rao, S.
登録日2020-07-27
公開日2020-08-05
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch.
Front Immunol, 11, 2020
7JK7
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CRYSTAL STRUCTURE OF IMPORTIN ALPHA 2 IN COMPLEX WITH LSD1 NLS S111E MUTANT
分子名称:Lysine-specific histone demethylase 1A, Importin subunit alpha-1, GLYCEROL
著者Tu, W.J., McCuaig, R., Tan, A.H.Y., Hardy, K., Seddiki, N., Ali, S., Dahlstron, J.E., Bean, E.G., Dunn, J., Forwood, J.K., Tsimbalyuk, S., Smith, K.M., Yip, D., Malik, L., Prasana, T., Milburn, P., Rao, S.
登録日2020-07-27
公開日2020-08-05
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch.
Front Immunol, 11, 2020
7CM2
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THE CRYSTAL STRUCTURE OF HUMAN USP7 USP DOMAIN FROM WUXI BIORTUS.
分子名称:Ubiquitin carboxyl-terminal hydrolase 7, GLYCEROL
著者Wang, F., Cheng, W., Lv, Z., Lin, D., Zhu, B., Miao, Q., Bao, X., Shang, H.
登録日2020-07-24
公開日2020-08-05
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献The Crystal Structure of human USP7 USP domain from Wuxi Biortus.
To Be Published
7JIR
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THE CRYSTAL STRUCTURE OF PAPAIN-LIKE PROTEASE OF SARS COV-2 , C111S MUTANT, IN COMPLEX WITH PLP_SNYDER457
分子名称:Papain-like protease, 5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide, ZINC ION, ...
著者Osipiuk, J., Tesar, C., Endres, M., Lisnyak, V., Maki, S., Taylor, C., Zhang, Y., Zhou, Z., Azizi, S.A., Jones, K., Kathayat, R., Snyder, S.A., Dickinson, B.C., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2020-07-23
公開日2020-08-05
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献The crystal structure of Papain-Like Protease of SARS CoV-2 , C111S mutant, in complex with PLP_Snyder457
to be published
7JIT
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THE CRYSTAL STRUCTURE OF PAPAIN-LIKE PROTEASE OF SARS COV-2 , C111S MUTANT, IN COMPLEX WITH PLP_SNYDER495
分子名称:Papain-like protease, 5-[(carbamoylcarbamoyl)amino]-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]benzamide, ZINC ION, ...
著者Osipiuk, J., Tesar, C., Endres, M., Lisnyak, V., Maki, S., Taylor, C., Zhang, Y., Zhou, Z., Azizi, S.A., Jones, K., Kathayat, R., Snyder, S.A., Dickinson, B.C., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2020-07-23
公開日2020-08-05
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献The crystal structure of Papain-Like Protease of SARS CoV-2 , C111S mutant, in complex with PLP_Snyder495
to be published
7JIV
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THE CRYSTAL STRUCTURE OF PAPAIN-LIKE PROTEASE OF SARS COV-2 , C111S MUTANT, IN COMPLEX WITH PLP_SNYDER530
分子名称:Papain-like protease, 5-(acryloylamino)-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]benzamide, ZINC ION, ...
著者Osipiuk, J., Tesar, C., Endres, M., Lisnyak, V., Maki, S., Taylor, C., Zhang, Y., Zhou, Z., Azizi, S.A., Jones, K., Kathayat, R., Snyder, S.A., Dickinson, B.C., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2020-07-23
公開日2020-08-05
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献The crystal structure of Papain-Like Protease of SARS CoV-2 , C111S mutant, in complex with PLP_Snyder530
to be published
7JIW
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THE CRYSTAL STRUCTURE OF PAPAIN-LIKE PROTEASE OF SARS COV-2 IN COMPLEX WITH PLP_SNYDER530
分子名称:Papain-Like Protease, 5-(acryloylamino)-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]benzamide, ZINC ION, ...
著者Osipiuk, J., Tesar, C., Endres, M., Lisnyak, V., Maki, S., Taylor, C., Zhang, Y., Zhou, Z., Azizi, S.A., Jones, K., Kathayat, R., Snyder, S.A., Dickinson, B.C., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2020-07-23
公開日2020-08-05
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The crystal structure of Papain-Like Protease of SARS CoV-2 in complex with PLP_Snyder530
to be published
6ZU8
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CRYSTAL STRUCTURE OF HUMAN BRACHYURY G177D VARIANT IN COMPLEX WITH AFATINIB
分子名称:Brachyury protein, ZINC ION, N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide
著者Newman, J.A., Gavard, A.E., Shrestha, L., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
登録日2020-07-21
公開日2020-08-05
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal structure of human Brachyury G177D variant in complex with Afatinib
To Be Published
7JHP
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CRYSTAL STRUCTURE OF HRAS IN COMPLEX WITH THE RAS-BINDING AND CYSTEINE-RICH DOMAINS OF CRAF-KINASE
分子名称:GTPase HRas, RAF proto-oncogene serine/threonine-protein kinase, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Cookis, T., Mattos, C.
登録日2020-07-21
公開日2020-08-05
実験手法X-RAY DIFFRACTION (2.766 Å)
主引用文献Crystal structure reveals the full Ras:Raf interface and advances mechanistic understanding of Raf activation
Biorxiv, 2020
7CKJ
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CRYSTAL STRUCTURE OF CMP KINASE IN COMPLEX WITH CMP FROM THERMUS THERMOPHILUS HB8
分子名称:Cytidylate kinase, CYTIDINE-5'-MONOPHOSPHATE
著者Mega, R., Nakagawa, N., Kuramitsu, S., Masui, R., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2020-07-17
公開日2020-07-29
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献The crystal structures of Thermus thermophilus CMP kinase complexed with a phosphoryl group acceptor and donor.
PLoS ONE, 15, 2020
7JFN
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CRYSTAL STRUCTURE OF LEUCINE-, ISOLEUCINE-, VALINE-, THREONINE-, AND ALANINE-BINDING PROTEIN FROM BRUCELLA OVIS, CLOSED CONFORMATION
分子名称:Putative branched chain amino acid ABC transporter, periplasmic amino acid-binding protein, NITRATE ION, ...
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2020-07-17
公開日2020-07-29
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal Structure of Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein from Brucella ovis, closed conformation
to be published
7JFQ
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THE CRYSTAL STRUCTURE OF 3CL MAINPRO OF SARS-COV-2 WITH DE-OXIDIZED C145
分子名称:3C-like proteinase, 1,2-ETHANEDIOL, FORMIC ACID
著者Tan, K., Maltseva, N.I., Welk, L.F., Jedrzejczak, R.P., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2020-07-17
公開日2020-07-29
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献The crystal structure of 3CL MainPro of SARS-CoV-2 with de-oxidized C145
To Be Published
6XT2
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EQADH-NADH-HEPTAFLUOROBUTANOL, P21
分子名称:Alcohol dehydrogenase E chain, ZINC ION, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ...
著者Plapp, B.V., Ramaswamy, S.
登録日2020-07-16
公開日2020-08-05
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Alternative binding modes in abortive NADH and alcohol complexes of horse liver alcohol dehydrogenase
To Be Published
6XS6
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SARS-COV-2 SPIKE D614G VARIANT, MINUS RBD
分子名称:Spike glycoprotein
著者Wang, X., Egri, S.B., Dudkina, N., Luban, J., Shen, K.
登録日2020-07-15
公開日2020-07-22
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant
Biorxiv, 2020
6ZSL
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CRYSTAL STRUCTURE OF THE SARS-COV-2 HELICASE AT 1.94 ANGSTROM RESOLUTION
分子名称:SARS-CoV-2 helicase NSP13, ZINC ION, PHOSPHATE ION
著者Newman, J.A., Yosaatmadja, Y., Douangamath, A., Arrowsmith, C.H., von Delft, F., Edwards, A., Bountra, C., Gileadi, O.
登録日2020-07-15
公開日2020-07-29
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Crystal structure of the SARS-CoV-2 helicase at 1.94 Angstrom resolution
To Be Published
7CJU
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CRYSTAL STRUCTURE OF INACTIVE FORM OF CHITOSANASE CRYSTALLIZED BY AMMONIUM SULFATE
分子名称:Glucanase
著者Guo, Y., Qu, L., Nishida, N., Hoshino, T.
登録日2020-07-14
公開日2020-07-29
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Electrostatic potential around the proteins crystallized by ammonium sulfate
To be published
6XR8
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DISTINCT CONFORMATIONAL STATES OF SARS-COV-2 SPIKE PROTEIN
分子名称:Spike glycoprotein, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zhang, J., Cai, Y.F., Xiao, T.S., Peng, H.Q., Sterling, S.M., Walsh Jr, R.M., Rawson, S., Volloch, S.R., Chen, B.
登録日2020-07-11
公開日2020-07-22
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Distinct conformational states of SARS-CoV-2 spike protein
Science, 2020
6XRA
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DISTINCT CONFORMATIONAL STATES OF SARS-COV-2 SPIKE PROTEIN
分子名称:Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zhang, J., Cai, Y.F., Xiao, T.S., Peng, H.Q., Sterling, S.M., Walsh Jr, R.M., Rawson, S., Rits-Volloch, S., Chen, B.
登録日2020-07-11
公開日2020-07-22
最終更新日2020-08-05
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Distinct conformational states of SARS-CoV-2 spike protein.
Science, 2020
6XQS
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EXTREME MALLEABILITY OF THE SARS-COV-2 3CL MPRO ACTIVE SITE CAVITY FACILITATES BINDING OF CLINICAL ANTIVIRALS: PROSPECTS FOR REPURPOSING EXISTING DRUGS AND RAMIFICATIONS FOR INHIBITOR DESIGN
分子名称:3C-like proteinase, (1S,3aR,6aS)-2-[(2S)-2-({(2S)-2-cyclohexyl-2-[(pyrazin-2-ylcarbonyl)amino]acetyl}amino)-3,3-dimethylbutanoyl]-N-[(2R,3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl]octahydrocyclopenta[c]pyrrole-1-carboxamide
著者Kneller, D.W., Kovalevsky, A., Coates, L.
登録日2020-07-10
公開日2020-07-22
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Extreme malleability of the SARS-CoV-2 3CL Mpro active site cavity facilitates binding of clinical antivirals: Prospects for repurposing existing drugs and ramifications for inhibitor design
To Be Published
6XQT
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EXTREME MALLEABILITY OF THE SARS-COV-2 3CL MPRO ACTIVE SITE CAVITY FACILITATES BINDING OF CLINICAL ANTIVIRALS: PROSPECTS FOR REPURPOSING EXISTING DRUGS AND RAMIFICATIONS FOR INHIBITOR DESIGN
分子名称:3C-like proteinase, (1R,2S,5S)-3-[N-({1-[(tert-butylsulfonyl)methyl]cyclohexyl}carbamoyl)-3-methyl-L-valyl]-N-{(1S)-1-[(1R)-2-(cyclopropyla mino)-1-hydroxy-2-oxoethyl]pentyl}-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
著者Kneller, D.W., Kovalevsky, A., Coates, L.
登録日2020-07-10
公開日2020-07-22
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Extreme malleability of the SARS-CoV-2 3CL Mpro active site cavity facilitates binding of clinical antivirals: Prospects for repurposing existing drugs and ramifications for inhibitor design
To Be Published
6XQU
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EXTREME MALLEABILITY OF THE SARS-COV-2 3CL MPRO ACTIVE SITE CAVITY FACILITATES BINDING OF CLINICAL ANTIVIRALS: PROSPECTS FOR REPURPOSING EXISTING DRUGS AND RAMIFICATIONS FOR INHIBITOR DESIGN
分子名称:3C-like proteinase, boceprevir (bound form)
著者Kneller, D.W., Kovalevsky, A., Coates, L.
登録日2020-07-10
公開日2020-07-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Extreme malleability of the SARS-CoV-2 3CL Mpro active site cavity facilitates binding of clinical antivirals: Prospects for repurposing existing drugs and ramifications for inhibitor design
To Be Published
6XQB
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SARS-COV-2 RDRP/RNA COMPLEX
分子名称:RNA-directed RNA polymerase, Non-structural protein 8, Non-structural protein 7, ...
著者Liu, B., Shi, W., Yang, Y.
登録日2020-07-09
公開日2020-07-29
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structure of SARS-CoV-2 RdRp/RNA complex at 3.4 Angstroms resolution
To Be Published
6XQD
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH SARECYCLINE, UUC-MRNA, AND DEACYLATED P-SITE TRNA AT 2.80A RESOLUTION
分子名称:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
著者Batool, Z., Lomakin, I.B., Bunick, C.G., Polikanov, Y.S.
登録日2020-07-09
公開日2020-08-05
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome
Proc.Natl.Acad.Sci.USA, 2020
167327
件を2020-08-05に公開中