2QC8

Crystal structure of human glutamine synthetase in complex with ADP and methionine sulfoximine phosphate

Summary for 2QC8

Entry DOI	10.2210/pdb2qc8/pdb
Related	2OJW
Descriptor	Glutamine synthetase, MANGANESE (II) ION, CHLORIDE ION, ... (6 entities in total)
Functional Keywords	amino-acid biosynthesis, ligase, synthetase, structural genomics, structural genomics consortium, sgc
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P15104
Total number of polymer chains	10
Total formula weight	442524.46
Authors	Karlberg, T.,Lehtio, L.,Arrowsmith, C.H.,Berglund, H.,Busam, R.D.,Collins, R.,Dahlgren, L.G.,Edwards, A.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Hogbom, M.,Johansson, I.,Kallas, A.,Kotenyova, T.,Moche, M.,Nordlund, P.,Nyman, T.,Persson, C.,Sagemark, J.,Sundstrom, M.,Thorsell, A.G.,Van Den Berg, S.,Weigelt, J.,Holmberg-Schiavone, L.,Structural Genomics Consortium (SGC) (deposition date: 2007-06-19, release date: 2007-07-03, Last modification date: 2023-08-30)
Primary citation	Krajewski, W.W.,Collins, R.,Holmberg-Schiavone, L.,Jones, T.A.,Karlberg, T.,Mowbray, S.L. Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design. J.Mol.Biol., 375:217-228, 2008 Cited by PubMed: 18005987 DOI: 10.1016/j.jmb.2007.10.029 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation