このページはRCSBの David S. Goodsell博士による「Molecule of the Month」2005年2月の記事を日本語に訳したものです。転載・引用については利用規約をご覧下さい。
「今月の分子」一覧に戻る / この記事のRCSBオリジナルサイト(英語)を見る
:翻訳 工藤高裕 (PDBj)
主要組織適合性複合体(MHC、PDB:1hsa)

ウイルスは油断のならない敵なので、我々はそれに対して数多くの防衛を行わなければならない。抗体は我々にとっても最初の防衛線である。抗体はウイルスに結合し、血液細胞を動員して破壊する。しかしもしウイルスがこの防衛をすり抜け細胞内に入ると何が起こるのだろうか?そうなると抗体はウイルスを見つけ出す方法がなくなり、ウイルスは安全になる。...しかしこれで終わりという訳ではない。

各細胞は第2の防衛線を持っている。それは細胞内が何かおかしくなった時に免疫機構への信号を利用する。細胞は常時古くなったり使われなくなったりしたタンパク質を分解し、その断片を細胞表面に提示している。小さなペプチドは 主要組織適合性複合体 (major Histocompatibility Complex、MHC)に保持される。MHCはペプチドをつかみ、それを免疫機構が検査できるようにしている。こうすることで、免疫機構は細胞内で起こっていることを監視できる。もし細胞表面に提示されたペプチドが全て通常通りなら、免疫機構は細胞に対して何もしない。ところが細胞内でウイルスが複製されていると、ウイルスタンパク質に由来する通常は見られないペプチドが多くのMHCによって提示される。免疫機構はそんな細胞を見つけると殺してしまう。

ペプチドの提示

免疫機構で用いられる多くのタンパク質と同様に、MHCも柔軟な結合部位によってつながれたいくつかの機能部位で構成されている。ここに示したPDBエントリー 1hsa の構造は細胞外部分だけを示している。橙で示した大きな鎖の上端には溝があり、そこに赤で示したペプチドが結合している。またピンクで示した小さい方の鎖はこの構造を安定化させている。タンパク質全体の中で橙の鎖は細胞膜を越えて下の方に延び、タンパク質を細胞表面に付着させている。ところがこの部分は大変柔軟性が高く、X線結晶解析が困難であるため分析からは取り除かれている。

活動中のMHC

ツタウルシ(poison ivy)によるかゆくなる反応はMHC機構によって引き起こされる。ツタウルシの葉の表面にある樹脂は皮膚のタンパク質と反応する。この毒された細胞はタンパク質を分解し、MHC分子を使って断片を提示する。かゆい発疹は免疫機構がこの断片を攻撃することで引き起こされる。更に深刻なのは、皮膚や臓器を移植する際にMHCが組織拒絶反応の原因となることである。これがこのタンパク質の名前の由来となっている。「組織適合性」(histocompatibility)という語句は、提供者(donor、ドナー)と患者との間で相性がよい移植相手を探すのが難しいことを指している。各個人はそれぞれ固有のMHC分子のセットを持っている。その種類は何百種類もあるが、各個人が持っているのはそのうちのたった4種類である(これは2種類ずつ両親から受け取ったものである)。異なるMHC型の皮膚断片を移植すると、免疫機構が発動され移植した細胞は破壊されてしまうだろう。それを回避する方策は、親類などの似たMHC分子セットを持つ人の中から型が一致する提供者を探すことである。

がんとのつながり

MHC機構は身体が持つ天然の抗がん作用にとっても重要であるという証拠が増えつつある。がん細胞も通常の細胞と同じように自分のタンパク質を分解した断片を細胞表面に提示する。もしがん細胞の持つタンパク質が、認識可能ながん変異を持っているなら、これは免疫機構に何かおかしいことを伝える信号となる。

型と専門用語

左:I型MHC(PDB:1hsa) 右:II型MHC(PDB:1dlh)

主に2種類のMHCが体内で使われている。既に述べてきたI型MHC(class I MHC)は、ほとんどの細胞表面で見られるもので、ウイルス感染から細胞を守っている。上図左に示したPDBエントリー 1hsa がその一例である。一方II型MHC(class II MHC)は、変なペプチドが提示されているのを見つけると体内のタンパク質を拾い上げて免疫機構を刺激する仕事をしている抗原提示細胞に特化して見られる。I型MHCと同様に、II型MHCも細胞表面につながれ、小さなペプチドを提示する窪みも持っている。ところが細かく見るといくつかの違いがある。II型MHCは両方の鎖に膜貫通部位が見られ、ペプチド結合部位は2つの鎖の間の溝に存在している。上図右に示した(PDBエントリー 1dlh )がII型MHCの一例である。科学の世界ではよくあることだが、注意が必要な専門用語がある。ヒトMHC分子はHLA(Human Leukocyte (Leucocyte) Antigen、ヒト白血球抗原)と呼ばれることが多い。

さまざまな折りたたみの型

3つの免疫機構タンパク質。左:T細胞受容体(PDB:1tcr、4ドメイン) 中央:抗体(PDB:1igt、12ドメイン) 右:MHC(PDB:2hla、2ドメイン)
免疫機構タンパク質共通のドメイン構造。βシートがジスルフィド結合で結合されている。

多くの免疫機構タンパク質は似た折りたたみ単位で構築されている。それは、βシート(ブロック矢印)の積み重なりが中央にある2つのシステインアミノ酸(cysteine、黄色い球)の間でジスルフィド結合が形成され固定されたものである。この共通するドメイン構造は、PDBデータベースで免疫機構タンパク質を見ると度々現れる。ここには3つの例を示した。左はT細胞受容体(T-cell receptor、PDBエントリー 1tcr )でこのドメインが4つ集まってできている。中央は抗体(antibody、PDBエントリー 1igt )でこのドメインが12個集まってできている。右はMHC(PDBエントリー 2hla )でこのドメインが2つ集まってできている。これらの親密なドメイン単位のアミノ酸が似ていることは、多くの免疫機構タンパク質が似た祖先タンパク質から進化してきたことを示している。

なお、遺伝的視点からみたMHCに関する追加情報が、欧州バイオインフォマティクス研究所(EBI)の「 今月のタンパク質 」で提供されているので合わせて参照いただきたい。

構造をみる

同じMHCに異なるペプチド結合した構造。左:水疱性口内炎ウイルス由来のペプチドが結合したもの(PDB:2vaa) 右:センダイウイルス由来のペプチドが結合したもの(PDB:2vab)

MHC機構全体として1つの問題がある。それは、各細胞が提示するペプチドは何千種類もあるのに、各細胞は数種類のMHCしか作らないことである。このジレンマを解決する方法は、異なるペプチドと結合したMHCの初期の構造によって明らかになった。ここには2つの構造を示した。左に示したのはPDBエントリー 2vaa 、右に示したのは 2vab で、2つの異なるウイルスに由来するペプチドが同じMHCに結合している。別の似た一連の構造がPDBエントリー 1hhg1hhh1hhi1hhj1hhk で見ることができる。これらの構造を見ると、9個のアミノ酸でできているペプチドが2つのαらせんの間の溝の中に伸びた構造で保持されているのが分かる(上から見た図、上図上)。MHCタンパク質は、黄色い星印で示したチロシン(tyrosine)の各末端でペプチドをつかんでいる。2つの構造でこの3つの位置が似ていることに注目して欲しい。ペプチドはこの場所でMHCにつながれているが、他のアミノ酸は外側に伸びてタンパク質から外れている。来月の「今月の分子」( T細胞受容体 )では、どのようにして免疫機構がこの外側にさらされたペプチドを認識するのかについて見ていくことにしよう。

2005/01/26 にPDBでFASTA検索を行って決定した主要組織適合性複合体(MHC)に関係するエントリーの一覧をこちらのリストに掲載しています。

2005/01/26 FASTA検索による関連PDBエントリー一覧
このリストを閉じるには右上の×をクリックして下さい
PDB ID Title Authors Publication Year Journal Name Volume No First Page Pubmed ID
1hsa The three-dimensional structure of HLA-B27 at 2.1 A resolution suggests a general mechanism for tight peptide binding to MHC. D.R.Madden, J.C.Gorga, J.L.Strominger, D.C.Wiley 1992 Cell 70 1035 1525820
1ogt Dual, HLA-B27 subtype-dependent conformation of a self-peptide. M.Hulsmeyer, M.T.Fiorillo, F.Bettosini, R.Sorrentino, W.Saenger, A.Ziegler, B.Uchanska-Ziegler 2004 J.Exp.Med. 199 271 14734527
1of2
1jge Hla-B27 Subtypes Differentially Associated with Disease Exhibit Subtle Structural Alterations M.Hulsmeyer, R.C.Hillig, A.Volz, M.Ruhl, W.Schroder, W.Saenger, A.Ziegler, B.Uchanska-Ziegler 2002 J.Biol.Chem. 277 47844 12244049
1k5n
1uxs Allele-dependent similarity between viral and self-peptide presentation by HLA-B27 subtypes. M.T.Fiorillo, C.Ruckert, M.Hulsmeyer, R.Sorrentino, W.Saenger, A.Ziegler, B.Uchanska-Ziegler 2005 J.Biol.Chem. 280 2962 15537660
1uxw
1jgd Thermodynamic and Structural Analysis of Peptide-and Allele-Dependent Properties of Two Hla-B27 Subtypes Exhibiting Differential Disease Association R.C.Hillig, M.Huelsmeyer, W.Saenger, K.Welfle, R.Misselwitz, H.Welfle, Kozerski C., A.Volz, B.Uchanska-Ziegler, A.Ziegler 2004 J.Biol.Chem. 279 652 14555655
1sys Natural Hla Class I Polymorphism Controls the Pathway of Antigen Presentation and Susceptibility to Viral Evasion D.Zernich, A.W.Purcell, W.A.Macdonald, L.Kjer-Nielsen, L.K.Ely, N.Laham, T.Crockford, N.A.Mifsud, M.Bharadwaj, L.Chang, B.D.Tait, R.Holdsworth, A.G.Brooks, S.P.Bottomley, T.Beddoe, C.A.Peh, J.Rossjohn, J.Mccluskey 2004 J.Exp.Med. 200 13 15226359
1syv
1n2r A Naturally Selected Dimorphism within the Hla-B44 Supertype Alters Class I Structure, Peptide Repertoire, and T Cell Recognition. W.A.Macdonald, A.W.Purcell, N.A.Mifsud, L.K.Ely, D.S.Williams, L.Chang, J.J.Gorman, C.S.Clements, L.Kjer-Nielsen, D.M.Koelle, S.R.Burrows, B.D.Tait, R.Holdsworth, A.G.Brooks, G.O.Lovrecz, L.Lu, J.Rossjohn, J.Mccluskey 2003 J.Exp.Med. 198 679 12939341
1m6o A naturally selected dimorphism within the HLA-B44 supertype alters class I structure, peptide repertoire, and T cell recognition. W.Macdonald, A.W.Purcell, D.S.Williams, N.Mifsud, L.K.Ely, J.J.Gorman, C.S.Clements, L.Kjer-Nielsen, D.M.Koelle, A.G.Brooks, G.O.Lovrecz, L.Lu, J.Rossjohn, J.Mccluskey 2003 J.Exp.Med. 198 679 12939341
1agd Antagonist HIV-1 Gag peptides induce structural changes in HLA B8. S.W.Reid, S.McAdam, K.J.Smith, P.Klenerman, C.A.O'Callaghan, K.Harlos, B.K.Jakobsen, A.J.McMichael, J.I.Bell, D.I.Stuart, E.Y.Jones 1996 J Exp Med 184 2279 8976183
1agf
1age
1agc
1agb
1m05 The Structure of Hla-B8 Complexed to an Immunodominant Viral Determinant: Peptide-Induced Conformational Changes and a Mode of Mhc Class I Dimerization. L.Kjer-Nielsen, C.S.Clements, A.G.Brooks, A.W.Purcell, M.R.Fontes, J.Mccluskey, J.Rossjohn 2003 J.Immunol. 169 5153 12391232
1mi5 A Structural Basis for the Selection of Dominant Alphabeta T Cell Receptors in Antiviral Immunity L.Kjer-Nielsen, C.S.Clements, A.W.Purcell, A.G.Brooks, J.C.Whisstock, S.R.Burrows, J.Mccluskey, J.Rossjohn 2003 Immunity 18 53 12530975
1a1o Bound water structure and polymorphic amino acids act together to allow the binding of different peptides to MHC class I HLA-B53. K.J.Smith, S.W.Reid, K.Harlos, A.J.McMichael, D.I.Stuart, J.I.Bell, E.Y.Jones 1996 Immunity 4 215 8624812
1a1m
1e27 Nonstandard Peptide Binding Revealed by Crystal Structures of Hla-B5101 Complexed with HIV Immunodominant Epitopes K.Maenaka, T.Maenaka, H.Tomiyama, M.Takiguchi, D.I.Stuart, E.Y.Jones 2000 J.Immunol. 165 3260 10975842
1e28
1xh3 Conformational Restraints and Flexibility of 14-Meric Peptides in Complex with Hla-B3501. M.Probst-Kepper, H.J.Hecht, H.Herrmann, V.Janke, F.Ocklenburg, J.Klempnauer, B.J.Van Den Eynde, S.Weiss 2004 J.Immunol. 173 5610 15494511
1a9b Decamer-like conformation of a nona-peptide bound to HLA-B*3501 due to non-standard positioning of the C terminus. R.Menssen, P.Orth, A.Ziegler, W.Saenger 1999 J Mol Biol 285 645 9878435
1a9e
1a1n An altered position of the alpha 2 helix of MHC class I is revealed by the crystal structure of HLA-B*3501. K.J.Smith, S.W.Reid, D.I.Stuart, A.J.McMichael, E.Y.Jones, J.I.Bell 1996 Immunity 4 203 8624811
1cg9 Complex Recognition of the Supertypic Bw6-Determinant on Hla-B and-C Molecules by the Monoclonal Antibody Sfr8-B6 R.Menssen, P.Orth, A.Ziegler, W.Saenger n/a To be Published n/a n/a n/a
1qvo Structures of Hla-A1101 Complexed with Immunodominant Nonamer and Decamer HIV-1 Epitopes Clearly Reveal the Presence of a Middle, Secondary Anchor Residue. L.Li, M.Bouvier 2004 J.Immunol. 172 6175 15128805
1q94
1efx Crystal Structure of an Nk Cell Immunoglobulin-Like Receptor in Complex with its Class I Mhc Ligand. J.C.Boyington, S.A.Motyka, P.Schuck, A.G.Brooks, P.D.Sun 2000 Nature 405 537 10850706
1im9 Crystal Structure of the Human Natural Killer Cell Inhibitory Receptor Kir2Dl1 Bound to its Mhc Ligand Hla-Cw4 Q.R.Fan, E.O.Long, D.C.Wiley 2001 Nat.Immunol. 2 452 11323700
1qqd Structure of Hla-Cw4, a Ligand for the Kir2D Natural Killer Cell Inhibitory Receptor Q.R.Fan, D.C.Wiley 1999 J. Exp. Med. 190 1 10429675
1w72 An Mhc:Peptide-Restricted Antibody and Tcr Molecules Recognize Their Target by Distinct Binding Modes: Crystal Structure of Hla-A1:Mage-A1 in Complex with Fab-Hyb3 M.Hulsmeyer, P.Chames, R.C.Hillig, R.L.Stanfield, G.Held, P.G.Coulie, C.Alings, G.Wille, W.Saenger, B.Uchanska-Ziegler, H.R.Hoogenboom, A.Ziegler 2004 J.Biol.Chem. n/a n/a n/a
1oga A Structural Basis for Immunodominant Human T Cell Receptor Recognition G.B.E.Stewart-Jones, A.J.Mcmichael, J.I.Bell, D.I.Stuart, E.Y.Jones 2003 Nat.Immunol. 4 657 n/a
1akj Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2. G.F.Gao, J.Tormo, U.C.Gerth, J.R.Wyer, A.J.McMichael, D.I.Stuart, J.I.Bell, E.Y.Jones, B.K.Jakobsen 1997 Nature 387 630 9177355
1p7q Crystal Structure of Hla-A2 Bound to Lir-1, a Host and Viral Major Histocompatibility Complex Receptor. B.E.Willcox, L.M.Thomas, P.J.Bjorkman 2003 Nat.Immunol. 4 913 12897781
1i1y The Structural Basis for the Increased Immunogenicity of Two HIV-Reverse Transcriptase Peptide Variant/Class I Major Histocompatibility Complexes T.J.Kirksey, R.R.Pogue-Caley, J.A.Frelinger, E.J.Collins 1999 J.Biol.Chem. 274 37259 10601290
1i1f
1hhi The antigenic identity of peptide-MHC complexes: a comparison of the conformations of five viral peptides presented by HLA-A2. D.R.Madden, D.N.Garboczi, D.C.Wiley 1993 Cell 75 693 7694806
1hhg
1hhk
1hhh
1hhj
1i7u T Cell Activity Correlates with Oligomeric Peptide/Mhc Binding on T Cell Surface J.Busslep, R.Zhao, D.Donnini, D.Loftus, M.Saad, E.Appella, E.J.Collins n/a To be Published n/a n/a n/a
1i7t
1i7r
1qr1 Poor Binding of a Her-2/Neu Epitope (Gp2) to Hla-A2.1 Is due to a Lack of Interactions with the Center of the Peptide J. J.Kuhns, M. A.Batalia, S.Yan, E. J.Collins 1999 J.Biol.Chem. 274 36422 10593938
1jht Crystal Structures of Two Closely Related But Antigenically Distinct Hla-A2/Melanocyte-Melanoma Tumor-Antigen Peptide Complexes P.Sliz, O.Michielin, J.C.Cerottini, I.Luescher, P.Romero, M.Karplus, D.C.Wiley 2001 J.Immunol. 167 3276 11544315
1jf1
1lp9 A Correlation between Tcr Valpha Docking on Mhc and Cd8 Dependence: Implications for T Cell Selection. J.Buslepp, H.Wang, W.E.Biddison, E.Appella, E.J.Collins 2003 Immunity 19 595 14563323
1i4f High Resolution Structure of Hla-A0201 in Complex with a Tumor-Specific Antigenic Peptide Encoded by the Mage-A4 Gene R.C.Hillig, P.G.Coulie, V.Stroobant, W.Saenger, A.Ziegler, M.Huelsmeyer 2001 J.Mol.Biol. 310 1167 11502003
1duy The Structure and Stability of an Hla-A0201/Octameric Tax Peptide Complex with an Empty Conserved Peptide-N-Terminal Binding Site A.R.Khan, B.M.Baker, P.Ghosh, W.E.Biddison, D.C.Wiley 2000 J.Immunol. 164 6398 10843695
1duz
1im3 Antigen Presentation Subverted: Structure of the Human Cytomegalovirus Protein Us2 Bound to the Class I Molecule Hla-A2 B.E.Gewurz, R.Gaudet, D.Tortorella, E.W.Wang, H.L.Ploegh, D.C.Wiley 2001 Proc. Nat. Acad. Sci. USA 98 6794 11391001
1b0g Structural evidence of T cell xeno-reactivity in the absence of molecular mimicry. R.Zhao, D.J.Loftus, E.Appella, E.J.Collins 1999 J Exp Med 189 359 9892618
1bz9
2clr Three-dimensional structure of a peptide extending from one end of a class I MHC binding site. E.J.Collins, D.N.Garboczi, D.C.Wiley 1994 Nature 371 626 7935798
1eez Substitution of Anchor Residues Alters Conformation of Residues at the Center of Her-2/Neu Epitope (Gp2) Complexed to Hla-A2.1 A.K.Sharma, J.J.Kuhns, E.J.Collins n/a To be Published n/a n/a n/a
1eey
1bd2 Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids. Y.H.Ding, K.J.Smith, D.N.Garboczi, U.Utz, W.E.Biddison, D.C.Wiley 1998 Immunity 8 403 9586631
1ao7 Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. D.N.Garboczi, P.Ghosh, U.Utz, Q.R.Fan, W.E.Biddison, D.C.Wiley 1996 Nature 384 134 8906788
1qew Human Class I Histocompatibility Antigen (Hla-A 0201) Complex with a Nonameric Peptide from Melanoma-Associated Antigen 3 (Residues 271-279) P.Orth, C.Alings, W.Saenger, A.Ziegler n/a To be Published n/a n/a n/a
1b0r Crystal structures of HLA-A*0201 complexed with antigenic peptides with either the amino- or carboxyl-terminal group substituted by a methyl group. M.Bouvier, H.C.Guo, K.J.Smith, D.C.Wiley 1998 Proteins 33 97 9741848
1s9y Functional and Structural Characteristics of NY-Eso-1-Related Hla A2-Restricted Epitopes and the Design of a Novel Immunogenic Analogue A.I.Webb, M.A.Dunstone, W.Chen, M.I.Aguilar, Q.Chen, H.Jackson, L.Chang, L.Kjer-Nielsen, T.Beddoe, J.Mccluskey, J.Rossjohn, A.W.Purcell 2004 J.Biol.Chem. 279 23438 15004033
1s9w
1s9x
1qrn Four A6-Tcr/Peptide/Hla-A2 Structures that Generate Very Different T Cell Signals are Nearly Identical Y.H.Ding, B.M.Baker, D.N.Garboczi, W.E.Biddison, D.C.Wiley 1999 Immunity 11 45 10435578
1qse
1qsf
1hsb Different length peptides bind to HLA-Aw68 similarly at their ends but bulge out in the middle. H.C.Guo, T.S.Jardetzky, T.P.Garrett, W.S.Lane, J.L.Strominger, D.C.Wiley 1992 Nature 360 364 1448153
2hla Specificity pockets for the side chains of peptide antigens in HLA-Aw68. T.P.Garrett, M.A.Saper, P.J.Bjorkman, J.L.Strominger, D.C.Wiley 1989 Nature 342 692 2594067
3hla n/a M.A.Saper, P.J.Bjorkman, D.C.Wiley n/a To be Published n/a n/a n/a
1hla Structure of the human class I histocompatibility antigen, HLA-A2. P.J.Bjorkman, M.A.Saper, B.Samraoui, W.S.Bennett, J.L.Strominger, D.C.Wiley 1987 Nature 329 506 3309677
1kpr Hla-E Allelic Variants: Correlating Differential Expression, Peptide Affinities, Crystal Structures and Thermal Stabilities R.K.Strong, M.A.Holmes, P.Li, L.Braun-Jones, N.Lee, D.E.Geraghty 2003 J.Biol.Chem. 278 5082 12411439
1ktl
1mhe Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E. C.A.O'Callaghan, J.Tormo, B.E.Willcox, V.M.Braud, B.K.Jakobsen, D.I.Stuart, A.J.McMichael, J.I.Bell, E.Y.Jones 1998 Mol Cell 1 531 9660937
1kjm Crystal Structures of Two Rat Mhc Class Ia (RT1-A) Molecules that are Associated Differentially with Peptide Transporter Alleles Tap-A and Tap-B. M.G.Rudolph, J.Stevens, J.A.Speir, J.Trowsdale, G.W.Butcher, E.Joly, I.A.Wilson 2002 J.Mol.Biol. 324 975 12470953
1kjv
1ed3 Bulged Structures for an Unusually Long Peptide Bound to Rat Mhc Class Irt1-A(A) J.A.Speir, J.Stevens, E.Joly, G.W.Butcher, I.A.Wilson 2001 Immunity 14 81 11163232
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1k8d Promiscuous Antigen Presentation by the Nonclassical Mhc Ib Qa-2 is Enabled by a Shallow, Hydrophobic Groove and Self-Stabilized Peptide Conformation X.He, P.Tabaczewski, J.Ho, I.Stroynowski, K.C.Garcia 2001 Structure 9 1213 11738047
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1jn6 Highly Specific Anti-Estradiol Antibodies: Structural Characterisation and Binding Diversity. C.Monnet, F.Bettsworth, E.A.Stura, M.-H.Le Du, R.Menez, L.Derrien, S.Zinn-Justin, B.Gilquin, G.Sibai, N.Battail-Poirot, M.Jolivet, A.Menez, M.Arnaud, F.Ducancel, J.B.Charbonnier 2002 J.Mol.Biol. 315 699 11812141
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1mie High-Resolution Crystal Structure of the Fab-Fragments of a Family of Mouse Catalytic Antibodies with Esterase Activity S.N.Ruzheinikov, T.A.Muranova, S.E.Sedelnikova, L.J.Partridge, G.M.Blackburn, I.A.Murray, H.Kakinuma, N.Takashi, K.Shimazaki, J.Sun, Y.Nishi, D.W.Rice 2003 J.Mol.Biol. 332 423 12948492
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3hfm Structure of an antibody-antigen complex: crystal structure of the HyHEL-10 Fab-lysozyme complex. E.A.Padlan, E.W.Silverton, S.Sheriff, G.H.Cohen, S.J.Smith-Gill, D.R.Davies 1989 Proc. Nat. Acad. Sci. USA 86 5938 2762305
1nby Dissection of Binding Interactions in the Complex between the Anti-Lysozyme Antibody Hyhel-63 and its Antigen Y.Li, M.Urrutia, S.J.Smith-Gill, R.A.Mariuzza 2003 Biochemistry 42 11 12515535
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1opg Crystal structure of the OPG2 Fab. An antireceptor antibody that mimics an RGD cell adhesion site. R.Kodandapani, B.Veerapandian, T.J.Kunicki, K.R.Ely 1995 J Biol Chem 270 2268 7836460
1bm3 Conformational change in an anti-integrin antibody: structure of OPG2 Fab bound to a beta 3 peptide. R.Kodandapani, L.Veerapandian, C.Z.Ni, C.K.Chiou, R.M.Whittal, T.J.Kunicki, K.R.Ely 1998 Biochem Biophys Res Commun 251 61 9790907
1ndg X-Ray Snapshots of the Maturation of an Antibody Response to a Protein Antigen Y.Li, H.Li, F.Yang, S.J.Smith-Gill, R.A.Mariuzza 2003 Nat.Struct.Biol. 10 482 12740607
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1dqj Three-Dimensional Structure of the Free and Antigen-Bound Fab from Monoclonal Antilysozyme Antibody Hyhel-63 Y.Li, H.Li, S.J.Smith-Gill, R.A.Mariuzza 2000 Biochemistry 39 6296 10828942
1lo4 A Structural Basis for the Activity of Retro-Diels-Alder Catalytic Antibodies: Evidence for a Catalytic Aromatic Residue M.Hugot, N.Bensel, M.Vogel, M.T.Reymond, B.Stadler, J.L.Reymond, U.Baumann 2002 Proc. Nat. Acad. Sci. USA 99 9674 12093912
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1kcr Crystal Structure of an Antibody Bound to an Immunodominant Peptide Epitope: Novel Features in Peptide-Antibody Recognition D.T.Nair, K.Singh, N.Sahu, K.V.S.Rao, D.M.Salunke 2000 J.Immunol. 165 6949 11120821
1iai Crystal structure of an idiotype-anti-idiotype Fab complex. N.Ban, C.Escobar, R.Garcia, K.Hasel, J.Day, A.Greenwood, A.McPherson 1994 Proc. Nat. Acad. Sci. USA 91 1604 8127852
1aif Structure of an anti-idiotypic Fab against feline peritonitis virus-neutralizing antibody and a comparison with the complexed Fab. N.Ban, C.Escobar, K.W.Hasel, J.Day, A.Greenwood, A.McPherson 1995 FASEB J 9 107 7821749
1a3l An antibody exo Diels-Alderase inhibitor complex at 1.95 angstrom resolution. A.Heine, E.A.Stura, J.T.Yli-Kauhaluoma, C.Gao, Q.Deng, B.R.Beno, K.N.Houk, K.D.Janda, I.A.Wilson 1998 Science 279 1934 9506943
1ruq Probing the Antibody-Catalyzed Water-Oxidation Pathway at Atomic Resolution. X.Zhu, P.Wentworth Jr., A.D.Wentworth, A.Eschenmoser, R.A.Lerner, I.A.Wilson 2004 Proc. Nat. Acad. Sci. USA 110 2247 14982995
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1a5f Primary and tertiary structures of the Fab fragment of a monoclonal anti-E-selectin 7A9 antibody that inhibits neutrophil attachment to endothelial cells. A.Rodriguez-Romero, O.Almog, M.Tordova, Z.Randhawa, G.L.Gilliland 1998 J Biol Chem 273 11770 9565600
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1bbd Three-dimensional structure of the Fab fragment of a neutralizing antibody to human rhinovirus serotype 2. J.Tormo, E.Stadler, T.Skern, H.Auer, O.Kanzler, C.Betzel, D.Blaas, I.Fita 1992 Protein Sci 1 1154 1338980
1e6j Mutual Conformational Adaptations in Antigen and Antibody Upon Complex Formation between an Fab and HIV-1 Capsid Protein P24 S.Monaco-Malbet, C.Berthet-Colominas, A.Novelli, N.Battai, N.Piga, V.Cheynet, F.Mallet, S.Cusack 2000 Structure Fold.Des. 8 1069 n/a
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1ken An Antibody that Prevents the Hemagglutinin Low Ph Fusogenic Transition C.Barbey-Martin, B.Gigant, T.Bizebard, L.J.Calder, S.A.Wharton, J.J.Skehel, M.Knossow 2002 Virology 294 70 11886266
12e8 Structure of a monoclonal 2E8 Fab antibody fragment specific for the low-density lipoprotein-receptor binding region of apolipoprotein E refined at 1.9 A. S.Trakhanov, S.Parkin, R.Raffai, R.Milne, Y.M.Newhouse, K.H.Weisgraber, B.Rupp 1999 Acta Crystallogr., Sect.D 0 122 10089402
1c12 Insight in Odorant Perception: The Crystal Structure and Binding Characteristics of Antibody Fragments Directed Against the Musk Odorant Traseolide A.C.Langedijk, S.Spinelli, C.Anguille, P.Hermans, J.Nederlof, J.Butenandt, A.Honegger, C.Cambillau, A.Pluckthun 1999 J.Mol.Biol. 292 855 10525411
3ck0 Structures of Angiotensin II and a Phage-Display Selected Cyclic Peptide in Complex with Fab131: Making Angiotensin II Analogs Y.H.Pan, K.H.Lee, M.Li, P.Ronco, L.M.Amzel n/a To be Published n/a n/a n/a
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1kem Insights into antibody catalysis: structure of an oxygenation catalyst at 1.9-angstrom resolution. L.C.Hsieh-Wilson, P.G.Schultz, R.C.Stevens 1996 Proc. Nat. Acad. Sci. USA 93 5363 8643580
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4fab Three-dimensional structure of a fluorescein-Fab complex crystallized in 2-methyl-2,4-pentanediol. J.N.Herron, X.M.He, M.L.Mason, E.W.Voss Jr., A.B.Edmundson 1989 Proteins 5 271 2508085
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1h3p Structural and Functional Characterisation of a Monoclonal Antibody Specific for the Pres1 Region of Hepatitis B Virus J.C.Pizarro, B.Vulliez-Le-Normand, M.M.Riottot, A.Budkowska, G.A.Bentley 2001 FEBS Lett. 509 463 n/a
1sy6 Crystal Structure of the Human T Cell Receptor Cd3(Epsilon)(Gamma) Heterodimer Complexed to the Therapeutic Mab Okt3. L.Kjer-Nielsen, M.A.Dunstone, L.Kostenko, L.K.Ely, T.Beddoe, N.A.Mifsud, A.W.Purcell, A.G.Brooks, J.Mccluskey, J.Rossjohn 2004 Proc. Nat. Acad. Sci. USA 101 7675 15136729
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1dcl Three-dimensional structure of a light chain dimer crystallized in water. Conformational flexibility of a molecule in two crystal forms. K.R.Ely, J.N.Herron, M.Harker, A.B.Edmundson 1989 J Mol Biol 210 601 2515285
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1axt Immune versus natural selection: antibody aldolases with enzymic rates but broader scope. .3.Barbas 3rd, A.Heine, G.Zhong, T.Hoffmann, S.Gramatikova, R.Bjornestedt, B.List, J.Anderson, E.A.Stura, I.A.Wilson, R.A.Lerner 1997 Science 278 2085 9405338
1uz6 Structure of an Anti-Lewis X Fab Fragment in Complex with its Lewis X Antigen A.M.M.Van Roon, N.S.Pannu, J.P.M.De Vrind, G.A.Van Der Marel, J.H.Van Boom, C.H.Hokke, A.M.Deelder, J.P.Abrahams 2004 Structure 12 1227 n/a
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1t66 Three-Dimensional Structures of Idiotypically Related Fabs with Intermediate and High Affinity for Fluorescein. S.Terzyan, P.A.Ramsland, E.W.Voss Jr., J.N.Herron, A.B.Edmundson 2004 J.Mol.Biol. 339 1141 15178254
1fpt Structure of the complex between the Fab fragment of a neutralizing antibody for type 1 poliovirus and its viral epitope. M.W.Wien, D.J.Filman, E.A.Stura, S.Guillot, F.Delpeyroux, R.Crainic, J.M.Hogle 1995 Nat Struct Biol 2 232 7539711
1tqc Insight Into the Prpc-->Prpsc Conversion from the Structures of Antibody-Bound Ovine Prion Scrapie-Susceptibility Variants F.Eghiaian, J.Grosclaude, S.Lesceu, P.Debey, B.Doublet, E.Treguer, H.Rezaei, M.Knossow 2004 Proc. Nat. Acad. Sci. USA 101 10254 15240887
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1tpx Insight Into the Prpc-> Prpsc Conversion from the Structures of Antibody-Bound Ovine Prion Scrapie-Susceptibility Variants. F.Eghiaian, J.Grosclaude, S.Lesceu, P.Debey, B.Doublet, E.Treguer, H.Rezaei, M.Knossow 2004 Proc. Nat. Acad. Sci. USA 101 10254 15240887
1rmf STRUCTURE OF A MONOCLONAL ANTI-ICAM-1 ANTIBODY R6.5 FAB FRAGMENT AT 2.8 ANGSTROM RESOLUTION. M.J.Jedrzejas, J.Miglietta, J.A.Griffin, M.Luo 1995 Acta Crystallogr., Sect.D 51 380 n/a
1ty5 Structural Basis for Allostery in Integrins and Binding to Fibrinogen-Mimetic Therapeutics T.Xiao, J.Takagi, B.S.Coller, J.-H.Wang, T.A.Springer 2004 Nature 432 59 15378069
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1nd0 Structural Basis for Antibody Catalysis of a Cationic Cyclization Reaction X.Zhu, A.Heine, F.Monnat, K.N.Houk, K.D.Janda, I.A.Wilson 2003 J.Mol.Biol. 329 69 12742019
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1igi 26-10 Fab-digoxin complex: affinity and specificity due to surface complementarity. P.D.Jeffrey, R.K.Strong, L.C.Sieker, C.Y.Chang, R.L.Campbell, G.A.Petsko, E.Haber, M.N.Margolies, S.Sheriff 1993 Proc. Nat. Acad. Sci. USA 90 10310 8234291
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1a6t Antibody-mediated neutralization of human rhinovirus 14 explored by means of cryoelectron microscopy and X-ray crystallography of virus-Fab complexes. Z.Che, N.H.Olson, D.Leippe, W.M.Lee, A.G.Mosser, R.R.Rueckert, T.S.Baker, T.J.Smith 1998 J Virol 72 4610 9573224
1k6q The Crystal Structure of Murine Fab D3 at 2.4 A Resolution in Comparison with the Humanised Fab D3H44 (1.85A) Provides Structural Insight Into the Humanisation Process of the D3 Anti-Tissue Factor Antibody K.Faelber, R.F.Kelley, D.Kirchhofer, Y.A.Muller n/a To be Published n/a n/a n/a
1ghf Crystal structure of an anti-anti-idiotype shows it to be self-complementary. N.Ban, J.Day, X.Wang, S.Ferrone, A.McPherson 1996 J Mol Biol 255 617 8568901
1ct8 Diverse Structural Solutions to Catalysis in a Family of Antibodies B.Gigant, T.Tsumuraya, I.Fujii, M.Knossow 1999 Structure (London) 7 1385 10574796
1i8m Crystal Structure of an Antigen-Binding Fragment Bound to Single-Stranded DNA J.J.Tanner, A.A.Komissarov, S.L.Deutscher 2001 J.Mol.Biol. 314 807 11733999
1p7k Structure of an Anti-DNA Fab Complexed with a Non-DNA Ligand Provides Insights Into Cross-Reactivity and Molecular Mimicry. J.P.Schuermann, M.T.Henzl, S.L.Deutscher, J.J.Tanner 2004 Proteins: Struct., Funct., Genet. 57 269 15340914
1e4x Crossreactive Binding of a Circularized Peptide to an Anti-Tgfalpha Antibody Fab-Fragment M.Hahn, D.Winkler, R.Misselwitz, H.Wessner, K.Wlefle, G.Zahn, J.Schneider-Mergener, W.Hoehne n/a To be Published n/a n/a n/a
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1baf 2.9 A resolution structure of an anti-dinitrophenyl-spin-label monoclonal antibody Fab fragment with bound hapten. A.T.Brunger, D.J.Leahy, T.R.Hynes, R.O.Fox 1991 J Mol Biol 221 239 1920408
1fig Routes to catalysis: structure of a catalytic antibody and comparison with its natural counterpart. M.R.Haynes, E.A.Stura, D.Hilvert, I.A.Wilson 1994 Science 263 646 8303271
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1ejo A Multiply Substituted G-H Loop from Foot-and-Mouth Disease Virus in Complex with a Neutralizing Antibody: A Role for Water Molecules W.F.Ochoa, S.G.Kalko, M.G.Mateu, P.Gomes, D.Andreu, E.Domingo, I.Fita, N.Verdaguer 2000 J.Gen.Virol. 81 1495 10811933
1hil Structural evidence for induced fit as a mechanism for antibody-antigen recognition. J.M.Rini, U.Schulze-Gahmen, I.A.Wilson 1992 Science 255 959 1546293
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1afv Crystal structure of dimeric HIV-1 capsid protein. C.Momany, L.C.Kovari, A.J.Prongay, W.Keller, R.K.Gitti, B.M.Lee, A.E.Gorbalenya, L.Tong, J.McClure, L.S.Ehrlich, M.F.Summers, C.Carter, M.G.Rossmann 1996 Nat Struct Biol 3 763 8784350
1frg Crystal structure of a peptide complex of anti-influenza peptide antibody Fab 26/9. Comparison of two different antibodies bound to the same peptide antigen. M.E.Churchill, E.A.Stura, C.Pinilla, J.R.Appel, R.A.Houghten, D.H.Kono, R.S.Balderas, G.G.Fieser, U.Schulze-Gahmen, I.A.Wilson 1994 J Mol Biol 241 534 7520084
1qfu A complex of influenza hemagglutinin with a neutralizing antibody that binds outside the virus receptor binding site. D.Fleury, B.Barrere, T.Bizebard, R.S.Daniels, J.J.Skehel, M.Knossow 1999 Nat Struct Biol 6 530 10360354
1nsn The crystal structure of the antibody N10-staphylococcal nuclease complex at 2.9 A resolution. P.Bossart-Whitaker, C.Y.Chang, J.Novotny, D.C.Benjamin, S.Sheriff 1995 J Mol Biol 253 559 7473734
1ifh Detailed analysis of the free and bound conformations of an antibody. X-ray structures of Fab 17/9 and three different Fab-peptide complexes. U.Schulze-Gahmen, J.M.Rini, I.A.Wilson 1993 J Mol Biol 234 1098 8263915
1nak Recurring Conformation of the Human Immunodeficiency Virus Type 1 Gp120 V3 Loop. R.L.Stanfield, J.B.Ghiara, E.Ollmann Saphire, A.T.Profy, I.A.Wilson 2003 Virology 315 159 14592768
1il1 Structure of an Anti-HIV Monoclonal Fab Antibody Fragment Specific to a Gp120 C-4 Region Peptide M.B.Berry, K.A.Johnson, W.Radding, M.Fung, R.Liou, G.N.Phillips Jr. 2001 Proteins: Struct., Funct., Genet. 45 281 11599031
1mhh Evidence for Plasticity and Structural Mimicry at the Immunoglobulin Light Chain-Protein L Interface M.Graille, S.Harrison, M.P.Crump, S.C.Findlow, N.G.Housden, B.H.Muller, N.Battail-Poirot, G.Sibai, B.J.Sutton, M.J.Taussig, C.Jolivet-Reynaud, M.G.Gore, E.A.Stura 2002 J.Biol.Chem. 277 47500 12221088
1n64 Crystal Structure of a Hydrophobic Immunodominant Antigenic Site on Hepatitis C Virus Core Protein Complexed to Monoclonal Antibody 19D9D6. R.Menez, M.Bossus, B.H.Muller, G.Sibai, P.Dalbon, F.Ducancel, C.Jolivet-Reynaud, E.A.Stura 2003 J.Immunol. 170 1917 12574359
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1jgu Structural Basis for a Disfavored Elimination Reaction in Catalytic Antibody 1D4 N.A.Larsen, A.Heine, L.Crane, B.F.Cravatt, R.A.Lerner, I.A.Wilson 2001 J.Mol.Biol. 314 93 11724535
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1jrh Neutralizing epitopes on the extracellular interferon gamma receptor (IFNgammaR) alpha-chain characterized by homolog scanning mutagenesis and X-ray crystal structure of the A6 fab-IFNgammaR1-108 complex. S.Sogabe, F.Stuart, C.Henke, A.Bridges, G.Williams, A.Birch, F.K.Winkler, J.A.Robinson 1997 J Mol Biol 273 882 9367779
15c8 Ligand-Induced Conformational Changes in a Catalytic Antibody: Comparison of the Bound and Unbound Structure of Fab 5C8 K.Gruber, A.Heine, E.A.Stura, C.G.Shevlin, I.A.Wilson n/a To be Published n/a n/a n/a
1dbj Molecular basis of crossreactivity and the limits of antibody-antigen complementarity. J.H.Arevalo, M.J.Taussig, I.A.Wilson 1993 Nature 365 859 8413674
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1dba Three-dimensional structure of an anti-steroid Fab' and progesterone-Fab' complex. J.H.Arevalo, E.A.Stura, M.J.Taussig, I.A.Wilson 1993 J Mol Biol 231 103 8496956
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1c1e Evolution of Shape Complementarity and Catalytic Efficiency from a Primordial Antibody Template J.Xu, Q.Deng, J.Chen, K.N.Houk, J.Bartek, D.Hilvert, I.A.Wilson 1999 Science 286 2345 10600746
1h0d The Crystal Structure of Human Angiogenin in Complex with an Antitumor Neutralizing Antibody G.Chavali, A.Papageorgiou, K.Olson, J.Fett, G.Hu, R.Shapiro, K.R.Acharya 2003 Structure 11 875 n/a
1t4k The Origin of Enantioselectivity in Aldolase Antibodies: Crystal Structure, Site-Directed Mutagenesis, and Computational Analysis X.Zhu, F.Tanaka, Y.Hu, A.Heine, R.Fuller, G.Zhong, A.J.Olson, R.A.Lerner, C.F.Barbas, I.A.Wilson 2004 J.Mol.Biol. 343 1269 15491612
1l7t Crystal Structure of an in Vitro Affinity-and Specificity-Matured Anti-Testosterone Fab in Complex with Testosterone. Improved Affinity Results from Small Structural Changes within the Variable Domains J.Valjakka, A.Hemminki, S.Niemi, H.Soderlund, K.Takkinen, J.Rouvinen 2002 J.Biol.Chem. 277 44021 12196551
1vpo Crystal Structure of an in Vitro Affinity- and Specificity-Matured Anti-Testosterone Fab in Complex with Testosterone. Improved Affinity Results from Small Structural Changes within the Variable Domains J.M.Valjakka, A.Hemminki, S.Niemi, H.Soderlund, K.Takkinen, J.Rouvinen 2002 J.Biol.Chem. 277 44021 12196551
1clz The x-ray structure of an anti-tumour antibody in complex with antigen. P.D.Jeffrey, J.Bajorath, C.Y.Chang, D.Yelton, I.Hellstrom, K.E.Hellstrom, S.Sheriff 1995 Nat Struct Biol 2 466 7664109
1otu Gating the Selectivity Filter in Clc Chloride Channels R.Dutzler, E.B.Campbell, R.Mackinnon 2003 Science 300 108 12649487
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1fe8 Identification of the Collagen-Binding Site of the Von Willebrand Factor A3-Domain R.A.P.Romijn, B.Bouma, W.Wuyster, P.Gros, J.Kroon, J.J.Sixma, E.G.Huizinga 2001 J.Biol.Chem. 276 9985 11098050
1v7m Structure of the Receptor-Binding Domain of Human Thrombopoietin Determined by Complexation with a Neutralizing Antibody Fragment M.D.Feese, T.Tamada, Y.Kato, Y.Maeda, M.Hirose, Y.Matsukura, H.Shigematsu, T.Muto, A.Matsumoto, H.Watarai, K.Ogami, T.Tahara, T.Kato, H.Miyazaki, R.Kuroki 2004 Proc. Nat. Acad. Sci. USA 101 1816 14769915
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6fab Three-dimensional structure of murine anti-p-azophenylarsonate Fab 36- 71. 1. X-ray crystallography, site-directed mutagenesis, and modeling of the complex with hapten. R.K.Strong, R.Campbell, D.R.Rose, G.A.Petsko, J.Sharon, M.N.Margolies 1991 Biochemistry 30 3739 2015229
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2f19 Three-Dimensional Structure of Two Crystal Forms of Fab R19.9, From a Monoclonal Anti-Arsonate Antibody M.-B.Lascombe, P.M.Alzari, R.J.Poljak, A.Nisonoff 1992 Proc. Nat. Acad. Sci. USA 89 9429 1409652
1fai Three-dimensional structure of two crystal forms of FabR19.9 from a monoclonal anti-arsonate antibody. M.B.Lascombe, P.M.Alzari, R.J.Poljak, A.Nisonoff 1992 Proc. Nat. Acad. Sci. USA 89 9429 1409652
1pz5 Structural Basis of Peptide-Carbohydrate Mimicry in an Antibody Combining Site. N.K.Vyas, M.N.Vyas, M.C.Chervenak, D.R.Bundle, B.M.Pinto, F.A.Quiocho 2003 Proc. Nat. Acad. Sci. USA 100 15023 14645714
1m7i Molecular Recognition of Oligosaccharide Epitopes by a Monoclonal Fab Specific for Shigella Flexneri Y Lipopolysaccharide: X-Ray Structures and Thermodynamics N.K.Vyas, M.N.Vyas, M.C.Chervenak, M.A.Johnson, B.M.Pinto, D.R.Bundle, F.A.Quiocho 2002 Biochemistry 41 13575 12427018
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1m71 Molecular Recognition of Oligosaccharide Epitopes by a Monoclonal Fab Specific for Shigella Flexneri Y Lipopolysaccharide: X-Ray Structures and Thermodyanamics N.K.Vyas, M.N.Vyas, M.C.Chervenak, M.A.Johnson, B.M.Pinto, D.R.Bundle, F.A.Quiocho 2002 Biochemistry 41 13575 12427018
1jfq Structural Analysis of Mutants of High-Affinity and Low-Affinity P-Azophenylarsonate-Specific Antibodies Generated by Alanine Scanning of Heavy Chain Complementarity-Determining Region 2. B.Parhami-Seren, M.Viswanathan, R.K.Strong, M.N.Margolies 2001 J.Immunol. 67 5129 11673524
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1qkz Crystal Structure of an Fab Fragment in Complex with a Meningococcal Serosubtype Antigen and a Protein G Domain J.P.Derrick, I.M.Feavers, M.C.J.Maiden 1999 J.Mol.Biol. 293 81 10512717
1iqw Crystal Structure of the Antigen-Binding Fragment of Apoptosis-Inducing Mouse Anti-Human Fas Monoclonal Antibody Hfe7A S.Ito, T.Takayama, H.Hanzawa, K.Ichikawa, J.Ohsumi, N.Serizawa, T.Hata, H Haruyama 2002 J.Biochem.(Tokyo) 131 137 11754745
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1sbs Structure of an Fab fragment against a C-terminal peptide of hCG at 2.0 A resolution. C.Fotinou, J.Beauchamp, P.Emsley, A.deHaan, W.J.Schielen, E.Bos, N.W.Isaacs 1998 J Biol Chem 273 22515 9712877
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1r24 The Role of Homophilic Binding in Anti-Tumor Antibody R24 Recognition of Molecular Surfaces. Demonstration of an Intermolecular Beta-Sheet Interaction between Vh Domains M.J.Kaminski, C.R Mackenzie, M.J.Mooibroek, T.E.Dahms, T.Hirama, A.N.Houghton, P.B.Chapman, S.V.Evans 1999 J.Biol.Chem. 274 5597 10026176
1for Structure determination of an Fab fragment that neutralizes human rhinovirus 14 and analysis of the Fab-virus complex. H.Liu, T.J.Smith, W.M.Lee, A.G.Mosser, R.R.Rueckert, N.H.Olson, R.H.Cheng, T.S.Baker 1994 J Mol Biol 240 127 8027997
1r0a Nonnucleoside Inhibitor Binding Affects the Interactions of the Fingers Subdomain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase with DNA. E.N.Peletskaya, A.A.Kogon, S.Tuske, E.Arnold, S.H.Hughes 2004 J.Virol. 78 3387 15016861
1t03 Structure of HIV-1 RT-DNA Complexes Before and After Incorporation of the Anti-Aids Drug Tenofovir S.Tuske, S.G.Sarafianos, A.D.Clark Jr., J.Ding, L.K.Naeger, K.L.White, M.D.Miller, C.S.Gibbs, P.L.Boyer, P.Clark, G.Wang, B.L.Gaffney, R.A.Jones, D.M.Jerina, S.H.Hughes, E.Arnold 2004 Nat.Struct.Mol.Biol. 11 469 15107837
1n6q Structures of HIV-1 Reverse Transcriptase with Pre-and Post-Translocation Aztmp-Terminated DNA S.G.Sarafianos, A.D.Clark Jr., K.Das, S.Tuske, J.J.Birktoft, I.Ilankumaran, A.R.Ramesha, J.M.Sayer, D.M.Jerina, P.L.Boyer, S.H.Hughes, E.Arnold 2002 Embo J. 21 6614 12456667
1n5y Structure of HIV-1 Reverse Transcriptase with Pre-Translocation and Post-Translocation Aztmp-Terminated DNA S.G.Sarafianos, A.D.Clark Jr., K.Das, S.Tuske, J.J.Birktoft, P.Ilankumaran, A.R.Ramesha, J.M.Sayer, D.M.Jerina, P.L.Boyer, S.H.Hughes, E.Arnold 2002 Embo J. 21 6614 12456667
1rjl Structural Investigation of B. Burgdorferi Ospb, a Bactericidal Fab Target M.Becker, J.Bunikis, B.D.Lade, J.J.Dunn, A.G.Barbour, C.L.Lawson n/a To be Published n/a n/a n/a
1psk The crystal structure of a Fab fragment to the melanoma-associated GD2 ganglioside. S.L.Pichla, R.Murali, R.M.Burnett 1997 J Struct Biol 119 6 9216084
1mex Antibody Catalysis of a Bimolecular Cycloaddition Reaction A.Heine, I.A.Wilson n/a To be Published n/a n/a n/a
1ncd Refined crystal structure of the influenza virus N9 neuraminidase-NC41 Fab complex. W.R.Tulip, J.N.Varghese, W.G.Laver, R.G.Webster, P.M.Colman 1992 J Mol Biol 227 122 1381757
1nca
1fbi Crystal structure of a cross-reaction complex between Fab F9.13.7 and guinea fowl lysozyme. J.Lescar, M.Pellegrini, H.Souchon, D.Tello, R.J.Poljak, N.Peterson, M.Greene, P.M.Alzari 1995 J Biol Chem 270 18067 7629116
1qbl Structural basis for the binding of an anti-cytochrome c antibody to its antigen: crystal structures of FabE8-cytochrome c complex to 1.8 A resolution and FabE8 to 2.26 A resolution. S.E.Mylvaganam, Y.Paterson, E.D.Getzoff 1998 J Mol Biol 281 301 9698550
1wej
1qbm
1mam Crystal structure to 2.45 A resolution of a monoclonal Fab specific for the Brucella A cell wall polysaccharide antigen. D.R.Rose, M.Przybylska, R.J.To, C.S.Kayden, R.P.Oomen, E.Vorberg, N.M.Young, D.R.Bundle 1993 Protein Sci 2 1106 8358294
1osp Crystal structure of Lyme disease antigen outer surface protein A complexed with an Fab. H.Li, J.J.Dunn, B.J.Luft, C.L.Lawson 1997 Proc. Nat. Acad. Sci. USA 94 3584 9108020
1ors X-Ray Structure of a Voltage-Dependent K+ Channel Y.Jiang, A.Lee, J.Chen, V.Ruta, M.Cadene, B.T.Chait, R.Mackinnon 2003 Nature 423 33 12721618
1orq
1igt Refined structure of an intact IgG2a monoclonal antibody. L.J.Harris, S.B.Larson, K.W.Hasel, A.McPherson 1997 Biochemistry 36 1581 9048542
1ncc Crystal structures of two mutant neuraminidase-antibody complexes with amino acid substitutions in the interface. W.R.Tulip, J.N.Varghese, R.G.Webster, W.G.Laver, P.M.Colman 1992 J Mol Biol 227 149 1522584
1ncb
1kb5 The three-dimensional structure of a T-cell antigen receptor V alpha V beta heterodimer reveals a novel arrangement of the V beta domain. D.Housset, G.Mazza, C.Gregoire, C.Piras, B.Malissen, J.C.Fontecilla-Camps 1997 EMBO J 16 4205 9250664
1emt X-Ray Crystal Structure of an Anti-Buckminsterfullerene Antibody Fab Fragment: Biomolecular Recognition of C60 B.C.Braden, F.A.Goldbaum, B.-X.Chen, A.N.Kirschner, S.R.Wilson, B.F.Erlanger 2000 Proc. Nat. Acad. Sci. USA 97 12193 11035793
1ai1 Structure-based design of a constrained peptide mimic of the HIV-1 V3 loop neutralization site. J.B.Ghiara, D.C.Ferguson, A.C.Satterthwait, H.J.Dyson, I.A.Wilson 1997 J Mol Biol 266 31 9054968
1mf2 Three-dimensional structure of an Fab-peptide complex: structural basis of HIV-1 protease inhibition by a monoclonal antibody. J.Lescar, R.Stouracova, M.M.Riottot, V.Chitarra, J.Brynda, M.Fabry, M.Horejsi, J.Sedlacek, G.A.Bentley 1997 J Mol Biol 267 1207 9150407
2hrp
1ob1 Crystal Structure of a Fab Complex Formed with Pfmsp1-19, the C-Terminal Fragment of Merozoite Surface Protein 1 from Plasmodium Falciparum: A Malaria Vaccine Candidate J.C.Pizarro, V.Chitarra, D.Verger, I.Holm, S.Petres, S.Dartville, F.Nato, S.Longacre, G.A.Bentley 2003 J.Mol.Biol. 328 1091 n/a
1acy Crystal structure of the principal neutralization site of HIV-1. J.B.Ghiara, E.A.Stura, R.L.Stanfield, A.T.Profy, I.A.Wilson 1994 Science 264 82 7511253
1ggb Major antigen-induced domain rearrangements in an antibody. R.L.Stanfield, M.Takimoto-Kamimura, J.M.Rini, A.T.Profy, I.A.Wilson 1993 Structure 1 83 8069628
1ggc
1cl7 Inhibition of the HIV-1 and HIV-2 Proteases by a Monoclonal Antibody J.Lescar, J.Brynda, P.Rezacova, R.Stouracova, M.-M.Riottot, V.Chitarra, M.Fabry, M.Horejsi, J.Sedlacek, G.A.Bentley 1999 Protein Sci. 8 2686 10631984
2pcp Crystal structure of monoclonal 6B5 Fab complexed with phencyclidine. K.Lim, S.M.Owens, L.Arnold, J.C.Sacchettini, D.S.Linthicum 1998 J Biol Chem 273 28576 9786848
1hyx A structural basis for transition-state stabilization in antibody-catalyzed hydrolysis: crystal structures of an abzyme at 1. 8 A resolution. O.Kristensen, D.G.Vassylyev, F.Tanaka, K.Morikawa, I.Fujii 1998 J Mol Biol 281 501 9698565
1hyy
1keg Crystal Structure of DNA (6-4) Photoproduct Dtt(6-4)Tt in Complex with the 64M-2 Antibody Fab Fragment Implies Increased Antibody-Binding Affinity by the Flanking Nucleotides H.Yokoyama, R.Mizutani, Y.Satow, K.Sato, Y.Komatsu, E.Ohtsuka, O.Nikaido n/a To be Published n/a n/a n/a
1ehl Crystal Structure of the 64M-2 Antibody Fab Fragment in Complex with a DNA Dt(6-4)T Photoproduct Formed by Ultraviolet Radiation H.Yokoyama, R.Mizutani, Y.Satow, Y.Komatsu, E.Ohtsuka, O.Nikaido 2000 J.Mol.Biol. 299 711 10835279
32c2 Structure of an Activity Suppressing Fab Fragment to Cytochrome P450 Aromatase: Insights Into the Antibody-Antigen Interactions M.W.Sawicki, P.C.Ng, B.M.Burkhart, V.Pletnev, T.Higashiyama, Y.Osawa, D.Ghosh 1999 Mol.Immunol. 36 423 10449095
1f11 Structure of the Fab Fragment from F124, a Monoclonal Antibody Specific for Hepatitis B Surface Antigen F.A.Saul, B.Vulliez-Le Normand, M.Passafiume, M.M.Riottot, G.A.Bentley 2000 Acta Crystallogr., Sect.D 56 945 10944330
1ggi Crystal structure of a human immunodeficiency virus type 1 neutralizing antibody, 50.1, in complex with its V3 loop peptide antigen. J.M.Rini, R.L.Stanfield, E.A.Stura, P.A.Salinas, A.T.Profy, I.A.Wilson 1993 Proc. Nat. Acad. Sci. USA 90 6325 8327513
2igf Crystal structures of an antibody to a peptide and its complex with peptide antigen at 2.8 A. R.L.Stanfield, T.M.Fieser, R.A.Lerner, I.A.Wilson 1990 Science 248 712 2333521
1igf
1i9j Structural Insights Into Steroid Hormone Binding J.Valjakka, K.Takkinenz, T.Teerinen, H.Soderlund, J.Rouvinen 2002 J.Biol.Chem. 277 4183 11707437
1i9i
1mcp Phosphocholine binding immunoglobulin Fab McPC603. An X-ray diffraction study at 2.7 A. Y.Satow, G.H.Cohen, E.A.Padlan, D.R.Davies 1986 J Mol Biol 190 593 3097327
2mcp Refined Crystal Structure of the Mcpc603 Fab-Phosphocholine Complex at 3.1 Angstroms Resolution E.A.Padlan, G.H.Cohen, D.R.Davies n/a To be Published n/a n/a n/a
1a0q A comparison of the crystallographic structures of two catalytic antibodies with esterase activity. J.L.Buchbinder, R.C.Stephenson, T.S.Scanlan, R.J.Fletterick 1998 J Mol Biol 282 1033 9753552
1oak Crystal structure of the von Willebrand factor A1 domain in complex with the function blocking NMC-4 Fab. R.Celikel, K.I.Varughese, ?.Madhusudan, A.Yoshioka, J.Ware, Z.M.Ruggeri 1998 Nat Struct Biol 5 189 9501911
1jgl Crystal Structure of a Recombinant Anti-Estradiol Fab Fragment in Complex with 17Beta-Estradiol U.Lamminmaki, J.A.Kankare 2001 J.Biol.Chem. 276 36687 11451948
1jhk
1fns Modulation of Von Willebrand Factor Conformation and Adhesive Function by an Internalized Water Molecule R.Celikel, Z.M.Ruggeri, K.I.Varughese 2000 Nat.Struct.Biol. 7 881 11017197
2h1p The Three-Dimensional Structures of a Polysaccharide Binding Antibody to Cryptococcus Neoformans and its Complex with a Peptide from a Phage Display Library: Implications for the Identification of Peptide Mimotopes A.C.M.Young, P.Valadon, A.Casadevall, M.D.Scharff, J.C.Sacchettini 1997 J.Mol.Biol. 274 622 9417940
1dqd Structure of Fab Hgr-2 F6, a Competitive Antagonist of the Glucagon Receptor L.M.Wright, A.M.Brzozowski, R.E.Hubbard, A.C.W.Pike, S.M.Roberts, R.N.Skovgaard, I.Svendsen, H.Vissing, R.P.Bywater 2000 Acta Crystallogr., Sect.D 56 573 10771426
1c5d The Crystal Structure of the Fab Fragment of a Rat Monoclonal Antibody Against the Main Immunogenic Region of the Human Muscle Acetylcholine Receptor M.Kontou, D.D.Leonidas, E.H.Vatzaki, P.Tsantili, A.Mamalaki, N.G.Oikonomakos, K.R.Acharya, S.J.Tzartos 2000 Eur.J.Biochem. 267 2389 10759865
1ahw The mechanism of an inhibitory antibody on TF-initiated blood coagulation revealed by the crystal structures of human tissue factor, Fab 5G9 and TF.G9 complex. M.Huang, R.Syed, E.A.Stura, M.J.Stone, R.S.Stefanko, W.Ruf, T.S.Edgington, I.A.Wilson 1998 J Mol Biol 275 873 9480775
1fgn
1plg Evidence for the extended helical nature of polysaccharide epitopes. The 2.8 A resolution structure and thermodynamics of ligand binding of an antigen binding fragment specific for alpha-(2-->8)-polysialic acid. S.V.Evans, B.W.Sigurskjold, H.J.Jennings, J.R.Brisson, R.To, W.C.Tse, E.Altman, M.Frosch, C.Weisgerber, H.D.Kratzin, et al. 1995 Biochemistry 34 6737 7538787
1lk3 Noncompetitive Antibody Neutralization of Il-10 Revealed by Protein Engineering and X-Ray Crystallography K.Josephson, B.C.Jones, L.J.Walter, R.Digiacomo, S.R.Indelicato, M.R.Walter 2002 Structure 10 981 12121653
1eo8 Structural Evidence for Recognition of a Single Epitope by Two Distinct Antibodies D.Fleury, R.S.Daniels, J.J.Skehel, M.Knossow, T.Bizebard 2000 Proteins: Struct., Funct., Genet. 40 572 10899782
1kno Crystal structure of the complex of a catalytic antibody Fab fragment with a transition state analog: structural similarities in esterase-like catalytic antibodies. J.B.Charbonnier, E.Carpenter, B.Gigant, B.Golinelli-Pimpaneau, Z.Eshhar, B.S.Green, M.Knossow 1995 Proc. Nat. Acad. Sci. USA 92 11721 8524836
1lhz Comparison of the Three-Dimensional Structures of a Human Bence-Jones Dimer Crystallized on Earth and Aboard Us Space Shuttle Mission Sts-95 S.S.Terzyan, C.R.Dewitt, P.A.Ramsland, P.C.Bourne, A.B.Edmundson 2003 J.Mol.Recog. 16 83 12720277
1lgv
1jvk Three-Dimensional Structure of an Immunoglobulin Light-Chain Dimer with Amyloidogenic Properties P.C.Bourne, P.A.Ramsland, L.Shan, Z.-C.Fan, C.R.Dewitt, B.B.Shultz, S.S.Terzyan, C.R.Moomaw, C.A.Slaughter, L.W.Guddat, A.B.Edmundson 2002 Acta Crystallogr., Sect.D 58 815 11976493
1aqk Three-dimensional structure of a human Fab with high affinity for tetanus toxoid. C.Faber, L.Shan, Z.Fan, L.W.Guddat, C.Furebring, M.Ohlin, C.A.Borrebaeck, A.B.Edmundson 1998 Immunotechnology 3 253 9530559
1cr9 Antibody Binding Defines a Structure for an Epitope that Participates in the Prpc-->Prpsc Conformational Change Z.F.Kanyo, K.M.Pan, R.A.Williamson, D.R.Burton, S.B.Prusiner, R.J.Fletterick, F.E.Cohen 1999 J.Mol.Biol. 293 855 10543972
1cu4
1ikf A conformation of cyclosporin A in aqueous environment revealed by the X-ray structure of a cyclosporin-Fab complex. D.Altschuh, O.Vix, B.Rees, J.C.Thierry 1992 Science 256 92 1566062
1yei Crossreactivity, efficiency and catalytic specificity of an esterase-like antibody. B.Gigant, J.Charbonnier, Z.Eshhar, B.S.Green, M.Knossow 1998 J Mol Biol 284 741 9826512
1yek
1yej
1kn4 Remarkable Remote Chiral Recognition in a Reaction Mediated by a Catalytic Antibody L.J.D'Souza, B.Gigant, M.Knossow, B.S.Green 2002 J.Am.Chem.Soc. 124 2114 11878955
1kn2
1yed Structural convergence in the active sites of a family of catalytic antibodies. J.B.Charbonnier, B.Golinelli-Pimpaneau, B.Gigant, D.S.Tawfik, R.Chap, D.G.Schindler, S.H.Kim, B.S.Green, Z.Eshhar, M.Knossow 1997 Science 275 1140 9027317
1yee
1yec
1q1j Structural Rationale for the Broad Neutralization of HIV-1 by Human Monoclonal Antibody 447-52D R.L.Stanfield, M.K.Gorny, C.Williams, S.Zolla-Pazner, I.A.Wilson 2004 Structure 12 193 n/a
1nl0 Crystal Structure of the Calcium-Stabilized Human Factor Ix Gla Domain Bound to a Conformation-Specific Anti-Factor Ix Antibody. M.Huang, B.C.Furie, B.Furie 2004 J.Biol.Chem. 279 14338 14722079
1ntl The Extended Multidomain Solution Structures of the Complement Protein Crry and its Chimaeric Conjugate Crry-Ig by Scattering, Analytical Ultracentrifugation and Constrained Modelling: Implications for Function and Therapy M.Aslam, J.M.Guthridge, B.K.Hack, R.J.Quigg, V.M.Holers, S.J.Perkins 2003 J.Mol.Biol. 329 525 12767833
1lil Pitfalls of molecular replacement: The structure determination of an immunoglobulin light-chain dimer. D.B.Huang, C.Ainsworth, A.Solomon, M.Schiffer 1996 Acta Crystallogr., Sect.D 52 1058 n/a
1tet Crystal structure of an anticholera toxin peptide complex at 2.3 A. M.Shoham 1993 J Mol Biol 232 1169 7690406
1cqk Structure of the Ch3 Domain from the Mak33 Antibody M.J.W.Thies, J.Mayer, J.Augustine, C.Frederick, H.Lilie, J.Buchner n/a To be Published n/a n/a n/a
1nfd Atomic structure of an alphabeta T cell receptor (TCR) heterodimer in complex with an anti-TCR fab fragment derived from a mitogenic antibody. J.Wang, K.Lim, A.Smolyar, M.Teng, J.Liu, A.G.Tse, J.Liu, R.E.Hussey, Y.Chishti, C.T.Thomson, R.M.Sweet, S.G.Nathenson, H.C.Chang, J.C.Sacchettini, E.L.Reinherz 1998 EMBO J 17 10 9427737
1iga The Fab and Fc fragments of IgA1 exhibit a different arrangement from that in IgG: a study by X-ray and neutron solution scattering and homology modelling. M.K.Boehm, J.M.Woof, M.A.Kerr, S.J.Perkins 1999 J Mol Biol 286 1421 10064707
1rzf Structural Basis of Tyrosine Sulfation and Vh-Gene Usage in Antibodies that Recognize the HIV Type 1 Coreceptor-Binding Site on Gp120 C.C.Huang, M.Venturi, S.Majeed, M.J.Moore, S.Phogat, M.-Y.Zhang, D.S.Dimitrov, W.A.Hendrickson, J.Robinson, J.Sodroski, R.Wyatt, H.Choe, M.Farzan, P.D.Kwong 2004 Proc. Nat. Acad. Sci. USA 101 2706 14981267
1igc The third IgG-binding domain from streptococcal protein G. An analysis by X-ray crystallography of the structure alone and in a complex with Fab. J.P.Derrick, D.B.Wigley 1994 J Mol Biol 243 906 7966308
1bln Preliminary crystallographic analysis of anti P-glycoprotein specific Fab MRK-16 in complex with its antigenic. S.Vasudevan, K.Johns, T.Tsuruo, D.R.Rose 1996 Protein and Peptide Letters 3 147 n/a
1yeg X-ray structures of a hydrolytic antibody and of complexes elucidate catalytic pathway from substrate binding and transition state stabilization through water attack and product release. B.Gigant, J.B.Charbonnier, Z.Eshhar, B.S.Green, M.Knossow 1997 Proc. Nat. Acad. Sci. USA 94 7857 9223277
1yeh
1yef
1l0y Crystal Structure of Two Superantigens from Streptococcus Pyogenes Complexed with Their Respective T Cell Receptor Ligands Reveal Novel Superantigen-T Cell Receptor Binding Modes and a Unique T Cell Signaling Complex H.Li, E.J.Sundberg, R.A.Mariuzza n/a To be Published n/a n/a n/a
1l0x Crystal Structure of Two Superantigen from Streptococcus Pyogenes Complexed with Their Respective T Cell Receptor Ligands Reveal Novel Superantigen-T Cell Receptor Binding Modes and a Unique T Cell Signaling Complex H.Li, E.J.Sundberg, R.A.Mariuzza n/a To be Published n/a n/a n/a
1jck Crystal structure of a T-cell receptor beta-chain complexed with a superantigen. B.A.Fields, E.L.Malchiodi, H.Li, X.Ysern, C.V.Stauffacher, P.M.Schlievert, K.Karjalainen, R.A.Mariuzza 1996 Nature 384 188 8906797
1sbb Three-dimensional structure of the complex between a T cell receptor beta chain and the superantigen staphylococcal enterotoxin B. H.Li, A.Llera, D.Tsuchiya, L.Leder, X.Ysern, P.M.Schlievert, K.Karjalainen, R.A.Mariuzza 1998 Immunity 9 807 9881971
1bec Crystal structure of the beta chain of a T cell antigen receptor. G.A.Bentley, G.Boulot, K.Karjalainen, R.A.Mariuzza 1995 Science 267 1984 7701320
2gfb Crystal structure of a catalytic antibody Fab with esterase-like activity. B.Golinelli-Pimpaneau, B.Gigant, T.Bizebard, J.Navaza, P.Saludjian, R.Zemel, D.S.Tawfik, Z.Eshhar, B.S.Green, M.Knossow 1994 Structure 2 175 8069632
1egj Structure of the Activation Domain of the Gm-Csf/Il-3/Il-5 Receptor Common Beta-Chain Bound to an Antagonist J.Rossjohn, W.J.Mckinstry, J.M.Woodcock, B.J.Mcclure, T.R.Hercus, M.W.Parker, A.F.Lopez, C.J.Bagley 2000 Blood 95 2491 10753826
1tcr An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex. K.C.Garcia, M.Degano, R.L.Stanfield, A.Brunmark, M.R.Jackson, P.A.Peterson, L.Teyton, I.A.Wilson 1996 Science 274 209 8824178
1kgc The 1.5 A Crystal Structure of a Highly Selected Antiviral T Cell Receptor Provides Evidence for a Structural Basis of Immunodominance L.Kjer-Nielsen, C.S.Clements, A.G.Brooks, A.W.Purcell, J.Mccluskey, J.Rossjohn 2002 Structure 10 1521 12429093
1ktk Structures of Two Streptococcal Superantigens Bound to Tcr Beta Chains Reveal Diversity in the Architecture of T Cell Signaling Complexes E.J.Sundberg, H.Li, A.S.Llera, J.K.Mccormick, J.Tormo, P.M.Schlievert, K.Karjalainen, R.A.Mariuzza 2002 Structure 10 687 12015151

主要組織適合性複合体(MHC)についてさらに知りたい方へ

以下の参考文献もご参照ください。

  • S. Sell 2001 Immunology, immunopathology and immunity. ASM Press , Washington, D. C.
  • K. Natarajan, H. Li, R. A. Mariuzza and D. H. Margulies 1999 MHC class I molecules, structure and function. Reviews in Immunogenetics 1 32-46
  • I. A. York and K. L. Rock 1996 Antigen processing and presentation by the class I major histocompatibility complex. Annual Review of Immunology 14 369-396
  • M. Matsumura, D. H. Fremont, P. A. Peterson and I. A. Wilson 1992 Emerging principles for the recognition of peptide antigens by MHC class I molecules. Science 257 927-934



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