8EST

REACTION OF PORCINE PANCREATIC ELASTASE WITH 7-SUBSTITUTED 3-ALKOXY-4-CHLOROISOCOUMARINS: DESIGN OF POTENT INHIBITORS USING THE CRYSTAL STRUCTURE OF THE COMPLEX FORMED WITH 4-CHLORO-3-ETHOXY-7-GUANIDINO-ISOCOUMARIN

Summary for 8EST

Entry DOI	10.2210/pdb8est/pdb
Descriptor	PORCINE PANCREATIC ELASTASE, SULFATE ION, CALCIUM ION, ... (5 entities in total)
Functional Keywords	hydrolase(serine proteinase)
Biological source	Sus scrofa (pig)
Cellular location	Secreted: P00772
Total number of polymer chains	1
Total formula weight	26363.88
Authors	Radhakrishnan, R.,Powers, J.C.,Meyerjunior, E.F. (deposition date: 1990-02-21, release date: 1992-10-15, Last modification date: 2011-07-13)
Primary citation	Powers, J.C.,Oleksyszyn, J.,Narasimhan, S.L.,Kam, C.M. Reaction of porcine pancreatic elastase with 7-substituted 3-alkoxy-4-chloroisocoumarins: design of potent inhibitors using the crystal structure of the complex formed with 4-chloro-3-ethoxy-7-guanidinoisocoumarin. Biochemistry, 29:3108-3118, 1990 Cited by PubMed: 2337582 DOI: 10.1021/bi00464a030 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.78 Å)

Structure validation