7TOR

Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein GR20

This is a non-PDB format compatible entry.

Summary for 7TOR

• Entry DOI: 10.2210/pdb7tor/pdb
• EMDB information: 26036
• Descriptor: 18S rRNA, 60S ribosomal protein L7, eL8, ... (85 entities in total)
• Functional Keywords: ribosomal binding peptide, als/ftd-associated dipeptide repeat protein, ribosome
• Biological source: Oryctolagus cuniculus (rabbit); More
• Total number of polymer chains: 86
• Total formula weight: 3184552.18

Authors

Loveland, A.B.,Svidritskiy, E.,Susorov, D.,Lee, S.,Park, A.,Zvornicanin, S.,Demo, G.,Gao, F.B.,Korostelev, A.A. (deposition date: 2022-01-24, release date: 2022-05-25, Last modification date: 2022-06-01)

• Primary citation: Loveland, A.B.,Svidritskiy, E.,Susorov, D.,Lee, S.,Park, A.,Zvornicanin, S.,Demo, G.,Gao, F.B.,Korostelev, A.A.; Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.; Nat Commun, 13:2776-2776, 2022; PubMed: 35589706; DOI: 10.1038/s41467-022-30418-0

Experimental method

ELECTRON MICROSCOPY (2.9 Å)