7TOP

Yeast 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein PR20

This is a non-PDB format compatible entry.

Summary for 7TOP

• Entry DOI: 10.2210/pdb7top/pdb
• EMDB information: 26033 26034
• Descriptor: 25S rRNA, 60S ribosomal protein L8-A, 60S ribosomal protein L9-A, ... (49 entities in total)
• Functional Keywords: ribosomal binding peptide, als/ftd-associated dipeptide repeat protein, ribosome
• Biological source: Saccharomyces cerevisiae (baker's yeast); More
• Total number of polymer chains: 48
• Total formula weight: 1997884.64

Authors

Loveland, A.B.,Svidritskiy, E.,Susorov, D.,Lee, S.,Park, A.,Zvornicanin, S.,Demo, G.,Gao, F.B.,Korostelev, A.A. (deposition date: 2022-01-24, release date: 2022-05-25, Last modification date: 2024-02-21)

• Primary citation: Loveland, A.B.,Svidritskiy, E.,Susorov, D.,Lee, S.,Park, A.,Zvornicanin, S.,Demo, G.,Gao, F.B.,Korostelev, A.A.; Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.; Nat Commun, 13:2776-2776, 2022; PubMed: 35589706; DOI: 10.1038/s41467-022-30418-0

Experimental method

ELECTRON MICROSCOPY (2.4 Å)