7SCJ

Cryo-EM structure of the human Exostosin-1 and Exostosin-2 heterodimer in complex with a 4-sugar oligosaccharide acceptor analog

Summary for 7SCJ

• Entry DOI: 10.2210/pdb7scj/pdb
• EMDB information: 25036
• Descriptor: Exostosin-1, Exostosin-2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: exostosin1, exostosin2, glycosyltransferase, heparan sulfate, acceptor, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 162801.60

Authors

Li, H.,Li, H. (deposition date: 2021-09-28, release date: 2022-09-28, Last modification date: 2023-05-17)

• Primary citation: Li, H.,Chapla, D.,Amos, R.A.,Ramiah, A.,Moremen, K.W.,Li, H.; Structural basis for heparan sulfate co-polymerase action by the EXT1-2 complex.; Nat.Chem.Biol., 19:565-574, 2023; PubMed: 36593275; DOI: 10.1038/s41589-022-01220-2

Experimental method

ELECTRON MICROSCOPY (3.4 Å)