7NWG

Mammalian pre-termination 80S ribosome with Hybrid P/E- and A/P-site tRNA's bound by Blasticidin S.

This is a non-PDB format compatible entry.

Summary for 7NWG

• Entry DOI: 10.2210/pdb7nwg/pdb
• EMDB information: 12631
• Descriptor: 28S Ribosomal RNA, Ribosomal protein S5, 40S ribosomal protein S6, ... (89 entities in total)
• Functional Keywords: inhibitor 80s termination complex blasticidin s translation nmd, ribosome
• Biological source: Oryctolagus cuniculus; More
• Total number of polymer chains: 86
• Total formula weight: 3512377.55

Authors

Powers, K.T.,Yadav, S.K.N.,Bufton, J.C.,Schaffitzel, C. (deposition date: 2021-03-16, release date: 2021-07-07, Last modification date: 2023-01-11)

• Primary citation: Powers, K.T.,Stevenson-Jones, F.,Yadav, S.K.N.,Amthor, B.,Bufton, J.C.,Borucu, U.,Shen, D.,Becker, J.P.,Lavysh, D.,Hentze, M.W.,Kulozik, A.E.,Neu-Yilik, G.,Schaffitzel, C.; Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA.; Nucleic Acids Res., 49:7665-7679, 2021; PubMed: 34157102; DOI: 10.1093/nar/gkab532

Experimental method

ELECTRON MICROSCOPY (3.8 Å)