7JJM

Crystal structure of Importin alpha 2 in complex with LSD1 NLS

Summary for 7JJM

• Entry DOI: 10.2210/pdb7jjm/pdb
• Descriptor: Lysine-specific histone demethylase 1A, Importin subunit alpha-1, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: importin demethylase, protein transport
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 54150.73

Authors

Tu, W.J.,McGuaig, R.,Tan, H.Y.A.,Hardy, C.,Seddiki, N.,Ali, S.,Dahlstrom, J.E.,Bean, E.G.,Dunn, J.,Forwood, J.K.,Tsimbalyuk, S.,Smith, K.M.,Yip, D.,Malik, L.,Prasana, T.,Milburn, P.,Rao, S. (deposition date: 2020-07-27, release date: 2020-08-05, Last modification date: 2023-10-18)

• Primary citation: Tu, W.J.,McCuaig, R.D.,Tan, A.H.Y.,Hardy, K.,Seddiki, N.,Ali, S.,Dahlstrom, J.E.,Bean, E.G.,Dunn, J.,Forwood, J.,Tsimbalyuk, S.,Smith, K.,Yip, D.,Malik, L.,Prasanna, T.,Milburn, P.,Rao, S.; Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch.; Front Immunol, 11:1228-, 2020; DOI: 10.3389/fimmu.2020.01228

Experimental method

X-RAY DIFFRACTION (2.06 Å)