7HVP

X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A COMPLEX BETWEEN A SYNTHETIC PROTEASE OF HUMAN IMMUNODEFICIENCY VIRUS 1 AND A SUBSTRATE-BASED HYDROXYETHYLAMINE INHIBITOR

Summary for 7HVP

Entry DOI	10.2210/pdb7hvp/pdb
Related PRD ID	PRD_000228
Descriptor	HIV-1 PROTEASE, INHIBITOR ACE-SER-LEU-ASN-PHE-PSI(CH(OH)-CH2N)-PRO-ILE VME (JG-365) (3 entities in total)
Functional Keywords	acid proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1
Cellular location	Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369
Total number of polymer chains	3
Total formula weight	22374.31
Authors	Swain, A.L.,Miller, M.M.,Green, J.,Rich, D.H.,Schneider, J.,Kent, S.B.H.,Wlodawer, A. (deposition date: 1990-09-13, release date: 1993-07-15, Last modification date: 2023-11-15)
Primary citation	Swain, A.L.,Miller, M.M.,Green, J.,Rich, D.H.,Schneider, J.,Kent, S.B.,Wlodawer, A. X-ray crystallographic structure of a complex between a synthetic protease of human immunodeficiency virus 1 and a substrate-based hydroxyethylamine inhibitor. Proc.Natl.Acad.Sci.USA, 87:8805-8809, 1990 Cited by PubMed: 2247451 DOI: 10.1073/pnas.87.22.8805 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation