7F29

Cryo-EM structure of the fibril formed by disaccharide-modified amyloid-beta(1-42)

Summary for 7F29

• Entry DOI: 10.2210/pdb7f29/pdb
• EMDB information: 31428
• Descriptor: Amyloid-beta A4 protein, beta-D-galactopyranose-(1-3)-2-amino-2-deoxy-alpha-D-galactopyranose, ACETIC ACID (3 entities in total)
• Functional Keywords: amyloid fibril, protein fibril
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 6
• Total formula weight: 25810.82

Authors

Xia, W.C.,Sun, Y.P.,Liu, C. (deposition date: 2021-06-10, release date: 2022-07-13)

• Primary citation: Liu, D.,Wei, Q.,Xia, W.,He, C.,Zhang, Q.,Huang, L.,Wang, X.,Sun, Y.,Ma, Y.,Zhang, X.,Wang, Y.,Shi, X.,Liu, C.,Dong, S.; O-Glycosylation Induces Amyloid-beta To Form New Fibril Polymorphs Vulnerable for Degradation; J.Am.Chem.Soc., 143:20216-20223, 2021; DOI: 10.1021/jacs.1c08607

Experimental method

ELECTRON MICROSCOPY (3.1 Å)