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6VPC

Structure of the SpCas9 DNA adenine base editor - ABE8e

Summary for 6VPC
Entry DOI10.2210/pdb6vpc/pdb
EMDB information21308
DescriptorCas9 (SpCas9) single-guide RNA (sgRNA), CRISPR-associated endonuclease Cas9, DNA target strand (TS), ... (7 entities in total)
Functional Keywordsbase editor, abe, cas9, crispr, dna binding protein-dna-rna complex, dna binding protein/dna/rna
Biological sourceStreptococcus pyogenes
More
Total number of polymer chains6
Total formula weight264575.83
Authors
Knott, G.J.,Lapinaite, A.,Doudna, J.A. (deposition date: 2020-02-03, release date: 2020-07-29, Last modification date: 2024-03-06)
Primary citationLapinaite, A.,Knott, G.J.,Palumbo, C.M.,Lin-Shiao, E.,Richter, M.F.,Zhao, K.T.,Beal, P.A.,Liu, D.R.,Doudna, J.A.
DNA capture by a CRISPR-Cas9-guided adenine base editor.
Science, 369:566-571, 2020
Cited by
PubMed: 32732424
DOI: 10.1126/science.abb1390
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (3.2 Å)
Structure validation

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