6VPC
Structure of the SpCas9 DNA adenine base editor - ABE8e
Summary for 6VPC
Entry DOI | 10.2210/pdb6vpc/pdb |
EMDB information | 21308 |
Descriptor | Cas9 (SpCas9) single-guide RNA (sgRNA), CRISPR-associated endonuclease Cas9, DNA target strand (TS), ... (7 entities in total) |
Functional Keywords | base editor, abe, cas9, crispr, dna binding protein-dna-rna complex, dna binding protein/dna/rna |
Biological source | Streptococcus pyogenes More |
Total number of polymer chains | 6 |
Total formula weight | 264575.83 |
Authors | Knott, G.J.,Lapinaite, A.,Doudna, J.A. (deposition date: 2020-02-03, release date: 2020-07-29, Last modification date: 2024-03-06) |
Primary citation | Lapinaite, A.,Knott, G.J.,Palumbo, C.M.,Lin-Shiao, E.,Richter, M.F.,Zhao, K.T.,Beal, P.A.,Liu, D.R.,Doudna, J.A. DNA capture by a CRISPR-Cas9-guided adenine base editor. Science, 369:566-571, 2020 Cited by PubMed: 32732424DOI: 10.1126/science.abb1390 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
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