6RRK

Crystal structure of the central region of human cohesin subunit STAG1 in complex with RAD21 peptide

Summary for 6RRK

Entry DOI	10.2210/pdb6rrk/pdb
Descriptor	Cohesin subunit SA-1, Double-strand-break repair protein rad21 homolog (2 entities in total)
Functional Keywords	cohesin, stromal antigen, chromatid, gene regulation
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	114895.27
Authors	Newman, J.A.,katis, V.L.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Bountra, C.,Gileadi, O. (deposition date: 2019-05-20, release date: 2019-06-26, Last modification date: 2024-01-24)
Primary citation	van der Lelij, P.,Newman, J.A.,Lieb, S.,Jude, J.,Katis, V.,Hoffmann, T.,Hinterndorfer, M.,Bader, G.,Kraut, N.,Pearson, M.A.,Peters, J.M.,Zuber, J.,Gileadi, O.,Petronczki, M. STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers. Life Sci Alliance, 3:-, 2020 Cited by PubMed: 32467316 DOI: 10.26508/lsa.202000725 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.17 Å)

Structure validation