6RLT

Trypanosoma brucei Seryl-tRNA Synthetase in Complex with 5'-O-(N-(L-seryl)-Sulfamoyl)uridine

Summary for 6RLT

• Entry DOI: 10.2210/pdb6rlt/pdb
• Related: 6HDZ 6HE1 6HE3 6HHV 6HHW 6HHX 6HHY 6HHZ 6HI0
• Descriptor: Seryl-tRNA synthetase, putative, GLYCEROL, SODIUM ION, ... (6 entities in total)
• Functional Keywords: coil-coil, beta barrel, trna synthetase, inhibitor, complex, ligase
• Biological source: Trypanosoma brucei gambiense
• Total number of polymer chains: 2
• Total formula weight: 109940.04

Authors

Pang, L.,De Graef, S.,Strelkov, S.V.,Weeks, S.D. (deposition date: 2019-05-02, release date: 2020-01-08, Last modification date: 2024-01-24)

• Primary citation: Pang, L.,Nautiyal, M.,De Graef, S.,Gadakh, B.,Zorzini, V.,Economou, A.,Strelkov, S.V.,Van Aerschot, A.,Weeks, S.D.; Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.; Acs Chem.Biol., 15:407-415, 2020; PubMed: 31869198; DOI: 10.1021/acschembio.9b00887

Experimental method

X-RAY DIFFRACTION (1.84 Å)