6P78

queuine lyase from Clostridium spiroforme bound to SAM and queuine

Summary for 6P78

• Entry DOI: 10.2210/pdb6p78/pdb
• Descriptor: Queuine lyase, IRON/SULFUR CLUSTER, 2-amino-5-({[(1S,4S,5S)-4,5-dihydroxycyclopent-2-en-1-yl]amino}methyl)-1,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, ... (5 entities in total)
• Functional Keywords: metal ion binding, 4 iron 4 sulfur cluster binding, radical sam enzyme, c-n lyase activity, lyase
• Biological source: [Clostridium] spiroforme DSM 1552
• Total number of polymer chains: 1
• Total formula weight: 30961.44

Authors

Almo, S.C.,Grove, T.L. (deposition date: 2019-06-05, release date: 2019-09-18, Last modification date: 2019-12-18)

• Primary citation: Yuan, Y.,Zallot, R.,Grove, T.L.,Payan, D.J.,Martin-Verstraete, I.,Sepic, S.,Balamkundu, S.,Neelakandan, R.,Gadi, V.K.,Liu, C.F.,Swairjo, M.A.,Dedon, P.C.,Almo, S.C.,Gerlt, J.A.,de Crecy-Lagard, V.; Discovery of novel bacterial queuine salvage enzymes and pathways in human pathogens.; Proc.Natl.Acad.Sci.USA, 116:19126-19135, 2019; PubMed: 31481610; DOI: 10.1073/pnas.1909604116

Experimental method

X-RAY DIFFRACTION (1.726 Å)