6P67

Crystal Structure of a Complex of human IL-7Ralpha with an anti-IL-7Ralpha 2B8 Fab

Summary for 6P67

Entry DOI	10.2210/pdb6p67/pdb
Descriptor	Anti-IL-7R 2B8 Fab heavy chain, anti-IL-7R 2B8 Fab light chain, Interleukin-7 receptor subunit alpha, ... (7 entities in total)
Functional Keywords	interleukin-7 receptor extracellular dohmain, antibody 2b8 fab fragment, protein polymer, immune system
Biological source	Mus musculus (Mouse) More
Total number of polymer chains	12
Total formula weight	296908.01
Authors	Walsh, S.T.R.,Kashi, L.,Kohnhorst, C.L. (deposition date: 2019-06-03, release date: 2019-09-04, Last modification date: 2024-03-13)
Primary citation	Hixon, J.A.,Andrews, C.,Kashi, L.,Kohnhorst, C.L.,Senkevitch, E.,Czarra, K.,Barata, J.T.,Li, W.,Schneider, J.P.,Walsh, S.T.R.,Durum, S.K. New anti-IL-7R alpha monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models. Leukemia, 34:35-49, 2020 Cited by PubMed: 31439943 DOI: 10.1038/s41375-019-0531-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation