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6NKS

Ternary complex crystal structure of K289M variant of DNA polymerase Beta with beta-gamma CHF analog of dGTP

Summary for 6NKS
Entry DOI10.2210/pdb6nks/pdb
DescriptorDNA polymerase beta, DNA (5'-D(P*GP*TP*CP*GP*G)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3'), ... (9 entities in total)
Functional Keywordsdna polymerase beta, conformational change, enzyme mechanism, lfer, transcription, transcription-dna complex, transcription/dna
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains4
Total formula weight48376.69
Authors
Batra, V.K.,Wilson, S.H. (deposition date: 2019-01-07, release date: 2020-01-08, Last modification date: 2024-03-13)
Primary citationBatra, V.K.,Alnajjar, K.S.,Sweasy, J.B.,McKenna, C.E.,Goodman, M.F.,Wilson, S.H.
Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography.
Biochemistry, 59:955-963, 2020
Cited by
PubMed: 31999437
DOI: 10.1021/acs.biochem.9b01072
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.349 Å)
Structure validation

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