6NEC

STRUCTURE OF RET PROTEIN TYROSINE KINASE DOMAIN IN COMPLEX WITH NINTEDANIB

Summary for 6NEC

• Entry DOI: 10.2210/pdb6nec/pdb
• Descriptor: Proto-oncogene tyrosine-protein kinase receptor Ret, methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate, FORMIC ACID, ... (4 entities in total)
• Functional Keywords: transferase, oncogene, ret, tyrosine kinase, atp-binding, thyroid cancer, non-small cell lung cancer, nintedanib, complex
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 72587.77

Authors

Terzyan, S.S.,Shen, T.,Wu, J.,Mooers, B.H.M. (deposition date: 2018-12-17, release date: 2019-06-05, Last modification date: 2023-10-11)

• Primary citation: Terzyan, S.S.,Shen, T.,Liu, X.,Huang, Q.,Teng, P.,Zhou, M.,Hilberg, F.,Cai, J.,Mooers, B.H.M.,Wu, J.; Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib.; J.Biol.Chem., 294:10428-10437, 2019; PubMed: 31118272; DOI: 10.1074/jbc.RA119.007682

Experimental method

X-RAY DIFFRACTION (1.87 Å)