6N4Q

CryoEM structure of Nav1.7 VSD2 (actived state) in complex with the gating modifier toxin ProTx2

Summary for 6N4Q

Entry DOI	10.2210/pdb6n4q/pdb
EMDB information	0341
Descriptor	Nav1.7 VSD2-NavAb chimera, Beta/omega-theraphotoxin-Tp2a, Fab light chain, ... (4 entities in total)
Functional Keywords	voltage-gated sodium channel, gating modifier toxin, membrane protein
Biological source	Arcobacter butzleri (strain RM4018) More
Total number of polymer chains	12
Total formula weight	245187.65
Authors	Xu, H.,Rohou, A.,Arthur, C.P.,Estevez, A.,Ciferri, C.,Payandeh, J.,Koth, C.M. (deposition date: 2018-11-20, release date: 2019-01-23, Last modification date: 2019-12-18)
Primary citation	Xu, H.,Li, T.,Rohou, A.,Arthur, C.P.,Tzakoniati, F.,Wong, E.,Estevez, A.,Kugel, C.,Franke, Y.,Chen, J.,Ciferri, C.,Hackos, D.H.,Koth, C.M.,Payandeh, J. Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin. Cell, 176:702-, 2019 Cited by PubMed: 30661758 DOI: 10.1016/j.cell.2018.12.018 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.6 Å)

Structure validation