6M89

Crystal structure of the core catalytic domain of human inositol phosphate multikinase in complex with quercetin

Summary for 6M89

Entry DOI	10.2210/pdb6m89/pdb
Descriptor	Inositol polyphosphate multikinase,Inositol polyphosphate multikinase, 3,5,7,3',4'-PENTAHYDROXYFLAVONE (3 entities in total)
Functional Keywords	kinase, inositol, inositol polyphosphate, transferase, quercetin, flavonoid, inhibitor, natural product, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	30130.15
Authors	Wang, H.,Shears, S.B. (deposition date: 2018-08-21, release date: 2019-01-23, Last modification date: 2023-10-11)
Primary citation	Gu, C.,Stashko, M.A.,Puhl-Rubio, A.C.,Chakraborty, M.,Chakraborty, A.,Frye, S.V.,Pearce, K.H.,Wang, X.,Shears, S.B.,Wang, H. Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis. J. Med. Chem., 62:1443-1454, 2019 Cited by PubMed: 30624931 DOI: 10.1021/acs.jmedchem.8b01593 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation