6HAW

Crystal structure of bovine cytochrome bc1 in complex with 2-pyrazolyl quinolone inhibitor WDH2G7

Summary for 6HAW

• Entry DOI: 10.2210/pdb6haw/pdb
• Descriptor: Cytochrome b-c1 complex subunit 1, mitochondrial, Cytochrome b-c1 complex subunit 9, 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, ... (24 entities in total)
• Functional Keywords: cytochrome bc1, malaria, electron transport
• Biological source: Bos taurus (cattle); More
• Total number of polymer chains: 10
• Total formula weight: 238530.04

Authors

Amporndanai, K.,Hong, W.D.,O'Neill, P.M.,Hasnain, S.S.,Antonyuk, S.V. (deposition date: 2018-08-08, release date: 2019-01-16, Last modification date: 2024-01-17)

• Primary citation: David Hong, W.,Leung, S.C.,Amporndanai, K.,Davies, J.,Priestley, R.S.,Nixon, G.L.,Berry, N.G.,Samar Hasnain, S.,Antonyuk, S.,Ward, S.A.,Biagini, G.A.,O'Neill, P.M.; Potent Antimalarial 2-Pyrazolyl Quinolonebc1(Qi) Inhibitors with Improved Drug-like Properties.; ACS Med Chem Lett, 9:1205-1210, 2018; PubMed: 30613327; DOI: 10.1021/acsmedchemlett.8b00371

Experimental method

X-RAY DIFFRACTION (3.45 Å)