6GE3

X-ray structure of TEAD4 (wildtype) complexed with YAP (wildtype): The role of residual flexibility and water molecules in the adaptation of a bound intrinsically disordered protein to mutations at a binding interface

Summary for 6GE3

• Entry DOI: 10.2210/pdb6ge3/pdb
• Descriptor: Transcriptional enhancer factor TEF-3, Transcriptional coactivator YAP1, MYRISTIC ACID, ... (5 entities in total)
• Functional Keywords: transcription factor, co-activator, transcription regulation, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 30471.50

Authors

Kallen, J. (deposition date: 2018-04-25, release date: 2018-09-19, Last modification date: 2018-10-31)

• Primary citation: Mesrouze, Y.,Bokhovchuk, F.,Izaac, A.,Meyerhofer, M.,Zimmermann, C.,Fontana, P.,Schmelzle, T.,Erdmann, D.,Furet, P.,Kallen, J.,Chene, P.; Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface.; Protein Sci., 27:1810-1820, 2018; PubMed: 30058229; DOI: 10.1002/pro.3493

Experimental method

X-RAY DIFFRACTION (1.85 Å)