6FUW

Cryo-EM structure of the human CPSF160-WDR33-CPSF30 complex bound to the PAS AAUAAA motif at 3.1 Angstrom resolution

Replaces:  6FBS

Summary for 6FUW

• Entry DOI: 10.2210/pdb6fuw/pdb
• EMDB information: 4225 4225
• Descriptor: Cleavage and polyadenylation specificity factor subunit 1, pre-mRNA 3' end processing protein WDR33, Cleavage and polyadenylation specificity factor subunit 4, ... (5 entities in total)
• Functional Keywords: 3' pre-mrna processing, polyadenylation, cpsf, beta propeller, aauaaa, rna binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 232646.51

Authors

Clerici, M.,Faini, M.,Jinek, M. (deposition date: 2018-02-28, release date: 2018-03-21, Last modification date: 2023-02-22)

• Primary citation: Clerici, M.,Faini, M.,Muckenfuss, L.M.,Aebersold, R.,Jinek, M.; Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex.; Nat. Struct. Mol. Biol., 25:135-138, 2018; PubMed: 29358758; DOI: 10.1038/s41594-017-0020-6

Experimental method

ELECTRON MICROSCOPY (3.07 Å)