6FSD

Mus musculus acetylcholinesterase in complex with 2-(4-Biphenylyloxy)-N-[3-(1-piperidinyl)propyl]-acetamide hydrochloride (10)

Summary for 6FSD

• Entry DOI: 10.2210/pdb6fsd/pdb
• Descriptor: Acetylcholinesterase, 2-(4-phenylphenoxy)-~{N}-(3-piperidin-1-ylpropyl)ethanamide, 2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL, ... (6 entities in total)
• Functional Keywords: inhibitor, hydrolase, acetylcholinesterase, protein binding
• Biological source: Mus musculus (Mouse)
• Total number of polymer chains: 2
• Total formula weight: 121685.58

Authors

Knutsson, S.,Engdahl, C.,Kumari, R.,Kindahl, T.,Forsgren, N.,Lindgren, C.,Kitur, S.,Kamau, L.,Ekstrom, F.,Linusson, A. (deposition date: 2018-02-19, release date: 2018-10-31, Last modification date: 2024-01-17)

• Primary citation: Knutsson, S.,Engdahl, C.,Kumari, R.,Forsgren, N.,Lindgren, C.,Kindahl, T.,Kitur, S.,Wachira, L.,Kamau, L.,Ekstrom, F.,Linusson, A.; Noncovalent Inhibitors of Mosquito Acetylcholinesterase 1 with Resistance-Breaking Potency.; J.Med.Chem., 61:10545-10557, 2018; PubMed: 30339371; DOI: 10.1021/acs.jmedchem.8b01060

Experimental method

X-RAY DIFFRACTION (2.7 Å)