6FN4
Apo form of UIC2 Fab complex of human-mouse chimeric ABCB1 (ABCB1HM)
Summary for 6FN4
| Entry DOI | 10.2210/pdb6fn4/pdb |
| Related | 6FN1 |
| EMDB information | 4281 4282 |
| Descriptor | Apo form of Human-mouse chimeric ABCB1 (ABCB1HM) in complex with Antigen binding fragment of UIC2., UIC2 Antigen Binding Fragment Light chain, UIC2 Antigen binding fragment Heavy chain, ... (5 entities in total) |
| Functional Keywords | membrane transport protein abcb1 abc exporter small molecule inhibitor antibody complex, membrane protein |
| Biological source | Homo sapiens More |
| Total number of polymer chains | 3 |
| Total formula weight | 191397.16 |
| Authors | Alam, A.,Locher, K.P. (deposition date: 2018-02-02, release date: 2018-02-21, Last modification date: 2021-06-02) |
| Primary citation | Alam, A.,Kung, R.,Kowal, J.,McLeod, R.A.,Tremp, N.,Broude, E.V.,Roninson, I.B.,Stahlberg, H.,Locher, K.P. Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1. Proc. Natl. Acad. Sci. U.S.A., 115:E1973-E1982, 2018 Cited by PubMed: 29440498DOI: 10.1073/pnas.1717044115 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (4.14 Å) |
Structure validation
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