6FGB

Human FcRn extra-cellular domain complexed with Fab fragment of Rozanolixizumab

Summary for 6FGB

• Entry DOI: 10.2210/pdb6fgb/pdb
• Descriptor: IgG receptor FcRn large subunit p51, Beta-2-microglobulin, 1519.g57- Light chain, ... (7 entities in total)
• Functional Keywords: fcrn, rozanolixizumab, ecd, fab, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 97353.17

Authors

Sarkar, K.,Ceska, T.,Meier, C. (deposition date: 2018-01-10, release date: 2018-08-29, Last modification date: 2024-01-17)

• Primary citation: Smith, B.,Kiessling, A.,Lledo-Garcia, R.,Dixon, K.L.,Christodoulou, L.,Catley, M.C.,Atherfold, P.,D'Hooghe, L.E.,Finney, H.,Greenslade, K.,Hailu, H.,Kevorkian, L.,Lightwood, D.,Meier, C.,Munro, R.,Qureshi, O.,Sarkar, K.,Shaw, S.P.,Tewari, R.,Turner, A.,Tyson, K.,West, S.,Shaw, S.,Brennan, F.R.; Generation and characterization of a high affinity anti-human FcRn antibody, rozanolixizumab, and the effects of different molecular formats on the reduction of plasma IgG concentration.; MAbs, 10:1111-1130, 2018; PubMed: 30130439; DOI: 10.1080/19420862.2018.1505464

Experimental method

X-RAY DIFFRACTION (2.9 Å)