6EZO

Eukaryotic initiation factor EIF2B in complex with ISRIB

Summary for 6EZO

• Entry DOI: 10.2210/pdb6ezo/pdb
• Related: 5b04
• EMDB information: 4162
• Descriptor: Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, Translation initiation factor eIF-2B subunit gamma, ... (6 entities in total)
• Functional Keywords: gef, complex, isrib, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 10
• Total formula weight: 528298.14

Authors

Faille, A.,Weis, F.,Zyryanova, A.,Warren, A.J.,Ron, D. (deposition date: 2017-11-16, release date: 2018-03-28, Last modification date: 2019-12-11)

• Primary citation: Zyryanova, A.F.,Weis, F.,Faille, A.,Alard, A.A.,Crespillo-Casado, A.,Sekine, Y.,Harding, H.P.,Allen, F.,Parts, L.,Fromont, C.,Fischer, P.M.,Warren, A.J.,Ron, D.; Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B.; Science, 359:1533-1536, 2018; PubMed: 29599245; DOI: 10.1126/science.aar5129

Experimental method

ELECTRON MICROSCOPY (4.1 Å)