6ETV

Crystal structure of KDM4D with tetrazolhydrazide compound 2

Summary for 6ETV

Entry DOI	10.2210/pdb6etv/pdb
Descriptor	Lysine-specific demethylase 4D, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ZINC ION, ... (11 entities in total)
Functional Keywords	kdm4d, ligand binding, tetrazolylhydrazide, tetrazole, inhibitor design, cancer, epigenetics, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	40692.43
Authors	Malecki, P.H.,Link, A.,Weiss, M.S.,Heinemann, U. (deposition date: 2017-10-27, release date: 2019-02-27, Last modification date: 2024-01-17)
Primary citation	Malecki, P.H.,Ruger, N.,Roatsch, M.,Krylova, O.,Link, A.,Jung, M.,Heinemann, U.,Weiss, M.S. Structure-Based Screening of Tetrazolylhydrazide Inhibitors versus KDM4 Histone Demethylases. Chemmedchem, 14:1828-1839, 2019 Cited by PubMed: 31475772 DOI: 10.1002/cmdc.201900441 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.18 Å)

Structure validation