6ENQ
Structure of human PPAR gamma LBD in complex with Lanifibranor (IVA337)
Summary for 6ENQ
| Entry DOI | 10.2210/pdb6enq/pdb |
| Descriptor | Peroxisome proliferator-activated receptor gamma, 4-[1-(1,3-benzothiazol-6-ylsulfonyl)-5-chloro-indol-2-yl]butanoic acid (3 entities in total) |
| Functional Keywords | nuclear hormone receptor, ppargamma modulator, lanifibranor, transcription |
| Biological source | Homo sapiens (Human) |
| Cellular location | Nucleus: P37231 |
| Total number of polymer chains | 2 |
| Total formula weight | 64853.47 |
| Authors | Boubia, B.,Poupardin, O.,Barth, M.,Amaudrut, J.,Broqua, P.,Tallandier, M.,Zeyer, D. (deposition date: 2017-10-06, release date: 2018-03-14, Last modification date: 2024-01-17) |
| Primary citation | Boubia, B.,Poupardin, O.,Barth, M.,Binet, J.,Peralba, P.,Mounier, L.,Jacquier, E.,Gauthier, E.,Lepais, V.,Chatar, M.,Ferry, S.,Thourigny, A.,Guillier, F.,Llacer, J.,Amaudrut, J.,Dodey, P.,Lacombe, O.,Masson, P.,Montalbetti, C.,Wettstein, G.,Luccarini, J.M.,Legendre, C.,Junien, J.L.,Broqua, P. Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR) alpha / gamma / delta Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate. J. Med. Chem., 61:2246-2265, 2018 Cited by PubMed: 29446942DOI: 10.1021/acs.jmedchem.7b01285 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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