6CQY

Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with EMPA and HI-6

Summary for 6CQY

Entry DOI	10.2210/pdb6cqy/pdb
Related	6CQT 6CQU 6CQV 6CQW 6CQX 6CQZ
Descriptor	Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	hydrolase cholinesterase, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	121302.47
Authors	Bester, S.M.,Guelta, M.A.,Pegan, S.D.,Height, J.J. (deposition date: 2018-03-16, release date: 2018-12-05, Last modification date: 2023-10-04)
Primary citation	Bester, S.M.,Guelta, M.A.,Cheung, J.,Winemiller, M.D.,Bae, S.Y.,Myslinski, J.,Pegan, S.D.,Height, J.J. Structural Insights of Stereospecific Inhibition of Human Acetylcholinesterase by VX and Subsequent Reactivation by HI-6. Chem. Res. Toxicol., 31:1405-1417, 2018 Cited by PubMed: 30462502 DOI: 10.1021/acs.chemrestox.8b00294 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.449 Å)

Structure validation