SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborDownloads

6COX

CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2) COMPLEXED WITH A SELECTIVE INHIBITOR, SC-558 IN I222 SPACE GROUP

Summary for 6COX

DescriptorCYCLOOXYGENASE-2, PROTOPORPHYRIN IX CONTAINING FE, 1-PHENYLSULFONAMIDE-3-TRIFLUOROMETHYL-5-PARABROMOPHENYLPYRAZOLE
Functional KeywordsPEROXIDASE, DIOXYGENASE, CYCLOOXYGENASE, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, INFLAMMATION, ARTHRITIS, PROSTAGLANDIN, PROSTAGLANDIN SYNTHASE, OXIDOREDUCTASE,OXIDOREDUCTASE
Biological sourceMus musculus (house mouse)
Cellular locationMicrosome membrane; Peripheral membrane protein 
Organ source
Total number of polymer chains2
Total molecular weight138091.49
Authors
Kurumbail, R.,Stallings, W. (deposition date: 1996-12-18, release date: 1997-12-24, modification date: 2011-07-13)
Primary citation
Kurumbail, R.G.,Stevens, A.M.,Gierse, J.K.,McDonald, J.J.,Stegeman, R.A.,Pak, J.Y.,Gildehaus, D.,Miyashiro, J.M.,Penning, T.D.,Seibert, K.,Isakson, P.C.,Stallings, W.C.
Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents.
Nature, 384:644-648, 1996
PubMed: 8967954
DOI: 10.1038/384644a0
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)

More Asymmetric unit images

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entries available on 2014-09-17
00:00 UTC / 09:00 JST