6CKC

Structure of PRMT5:MEP50 in complex with LLY-283, a potent and selective inhibitor of PRMT5, with antitumor activity

Summary for 6CKC

• Entry DOI: 10.2210/pdb6ckc/pdb
• Descriptor: Protein arginine N-methyltransferase 5, Methylosome protein 50, 7-[(5R)-5-C-phenyl-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, ... (4 entities in total)
• Functional Keywords: inhibitor, complex, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 111506.93

Authors

Antonysamy, S. (deposition date: 2018-02-27, release date: 2018-05-16, Last modification date: 2024-03-13)

• Primary citation: Bonday, Z.Q.,Cortez, G.S.,Grogan, M.J.,Antonysamy, S.,Weichert, K.,Bocchinfuso, W.P.,Li, F.,Kennedy, S.,Li, B.,Mader, M.M.,Arrowsmith, C.H.,Brown, P.J.,Eram, M.S.,Szewczyk, M.M.,Barsyte-Lovejoy, D.,Vedadi, M.,Guccione, E.,Campbell, R.M.; LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity.; ACS Med Chem Lett, 9:612-617, 2018; PubMed: 30034588; DOI: 10.1021/acsmedchemlett.8b00014

Experimental method

X-RAY DIFFRACTION (2.8 Å)