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6BN7

Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET23 PROTAC.

Summary for 6BN7
Entry DOI10.2210/pdb6bn7/pdb
DescriptorDNA damage-binding protein 1, Protein cereblon, Bromodomain-containing protein 4, ... (5 entities in total)
Functional Keywordsprotac, degrader, e3 ligase, crbn, ligase
Biological sourceHomo sapiens (Human)
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Total number of polymer chains3
Total formula weight165480.97
Authors
Nowak, R.P.,DeAngelo, S.L.,Buckley, D.,Bradner, J.E.,Fischer, E.S. (deposition date: 2017-11-16, release date: 2018-05-30, Last modification date: 2023-10-04)
Primary citationNowak, R.P.,DeAngelo, S.L.,Buckley, D.,He, Z.,Donovan, K.A.,An, J.,Safaee, N.,Jedrychowski, M.P.,Ponthier, C.M.,Ishoey, M.,Zhang, T.,Mancias, J.D.,Gray, N.S.,Bradner, J.E.,Fischer, E.S.
Plasticity in binding confers selectivity in ligand-induced protein degradation.
Nat. Chem. Biol., 14:706-714, 2018
Cited by
PubMed: 29892083
DOI: 10.1038/s41589-018-0055-y
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.501 Å)
Structure validation

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