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6BLW

Zinc finger Domain of WT1(+KTS form) with M342R Mutation and 17+1mer Oligonucleotide with Triplet GGT

Summary for 6BLW
Entry DOI10.2210/pdb6blw/pdb
DescriptorWilms tumor protein, DNA (5'-D(P*GP*CP*GP*AP*AP*AP*TP*GP*GP*GP*AP*GP*GP*GP*TP*T)-3'), DNA (5'-D(*TP*AP*AP*CP*CP*CP*TP*CP*CP*CP*AP*TP*TP*TP*CP*GP*C)-3'), ... (7 entities in total)
Functional Keywordsprotein-dna complex wilms tumor suppressor protein zinc-fingers, dna binding protein-dna complex, dna binding protein/dna
Biological sourceHomo sapiens (Human)
More
Cellular locationNucleus . Isoform 1: Nucleus speckle . Isoform 4: Nucleus, nucleoplasm : P19544
Total number of polymer chains3
Total formula weight26862.75
Authors
Horton, J.R.,Cheng, X. (deposition date: 2017-11-11, release date: 2018-01-03, Last modification date: 2018-05-16)
Primary citationWang, D.,Horton, J.R.,Zheng, Y.,Blumenthal, R.M.,Zhang, X.,Cheng, X.
Role for first zinc finger of WT1 in DNA sequence specificity: Denys-Drash syndrome-associated WT1 mutant in ZF1 enhances affinity for a subset of WT1 binding sites.
Nucleic Acids Res., 46:3864-3877, 2018
Cited by
PubMed: 29294058
DOI: 10.1093/nar/gkx1274
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.835 Å)
Structure validation

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