6BE6

ADAM10 Extracellular Domain

Summary for 6BE6

• Entry DOI: 10.2210/pdb6be6/pdb
• Related: 6BDZ
• Descriptor: Disintegrin and metalloproteinase domain-containing protein 10, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: adam10, membrane protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 203797.87

Authors

Seegar, T.C.M. (deposition date: 2017-10-24, release date: 2017-12-27, Last modification date: 2023-10-04)

• Primary citation: Seegar, T.C.M.,Killingsworth, L.B.,Saha, N.,Meyer, P.A.,Patra, D.,Zimmerman, B.,Janes, P.W.,Rubinstein, E.,Nikolov, D.B.,Skiniotis, G.,Kruse, A.C.,Blacklow, S.C.; Structural Basis for Regulated Proteolysis by the alpha-Secretase ADAM10.; Cell, 171:1638-1648.e7, 2017; PubMed: 29224781; DOI: 10.1016/j.cell.2017.11.014

Experimental method

X-RAY DIFFRACTION (2.8 Å)