6B8J

Co-structure of human glycogen synthase kinase beta with a selective (5-imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine inhibitor

Summary for 6B8J

• Entry DOI: 10.2210/pdb6b8j/pdb
• Descriptor: Glycogen synthase kinase-3 beta, VAL-SEP-ARG-ARG, GLYCEROL, ... (5 entities in total)
• Functional Keywords: kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm : P49841
• Total number of polymer chains: 2
• Total formula weight: 48037.22

Authors

Bussiere, D.E. (deposition date: 2017-10-08, release date: 2017-11-08)

• Primary citation: Wagman, A.S.,Boyce, R.S.,Brown, S.P.,Fang, E.,Goff, D.,Jansen, J.M.,Le, V.P.,Levine, B.H.,Ng, S.C.,Ni, Z.J.,Nuss, J.M.,Pfister, K.B.,Ramurthy, S.,Renhowe, P.A.,Ring, D.B.,Shu, W.,Subramanian, S.,Zhou, X.A.,Shafer, C.M.,Harrison, S.D.,Johnson, K.W.,Bussiere, D.E.; Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3.; J. Med. Chem., 60:8482-8514, 2017; PubMed: 29016121; DOI: 10.1021/acs.jmedchem.7b00922

Experimental method

X-RAY DIFFRACTION (2.595 Å)