6AO5

Crystal structure of human MST2 in complex with SAV1 SARAH domain

Summary for 6AO5

• Entry DOI: 10.2210/pdb6ao5/pdb
• Descriptor: Serine/threonine-protein kinase 3, Protein salvador homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (4 entities in total)
• Functional Keywords: hippo, mst autoactivation, dimerization, signaling protein
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm : Q13188; Nucleus : Q9H4B6
• Total number of polymer chains: 2
• Total formula weight: 53535.43

Authors

Tomchick, D.R.,Luo, X.,Ni, L. (deposition date: 2017-08-15, release date: 2017-11-08, Last modification date: 2023-10-04)

• Primary citation: Bae, S.J.,Ni, L.,Osinski, A.,Tomchick, D.R.,Brautigam, C.A.,Luo, X.; SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK.; Elife, 6:-, 2017; PubMed: 29063833; DOI: 10.7554/eLife.30278

Experimental method

X-RAY DIFFRACTION (2.955 Å)