6AN1

Crystal structure of the complex between PPARgamma LBD and the ligand AM-879

Summary for 6AN1

Entry DOI	10.2210/pdb6an1/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, 4-({2-[(1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)methyl]phenoxy}methyl)benzoic acid (3 entities in total)
Functional Keywords	nuclear receptor, ligand binding domain, nuclear protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	65629.87
Authors	Veras, H.,Figueira, A.C.,le Maire, A. (deposition date: 2017-08-11, release date: 2018-02-14, Last modification date: 2024-03-13)
Primary citation	Ribeiro Filho, H.V.,Bernardi Videira, N.,Bridi, A.V.,Tittanegro, T.H.,Helena Batista, F.A.,de Carvalho Pereira, J.G.,de Oliveira, P.S.L.,Bajgelman, M.C.,Le Maire, A.,Figueira, A.C.M. Screening for PPAR Non-Agonist Ligands Followed by Characterization of a Hit, AM-879, with Additional No-Adipogenic and cdk5-Mediated Phosphorylation Inhibition Properties. Front Endocrinol (Lausanne), 9:11-11, 2018 Cited by PubMed: 29449830 DOI: 10.3389/fendo.2018.00011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.687 Å)

Structure validation