6ALE

A V-to-F substitution in SK2 channels causes Ca2+ hypersensitivity and improves locomotion in a C. elegans ALS model

Summary for 6ALE

Entry DOI	10.2210/pdb6ale/pdb
Descriptor	Small conductance calcium-activated potassium channel protein 2, Calmodulin-2, SULFATE ION, ... (7 entities in total)
Functional Keywords	calcium binding protein, metal transport
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	28538.93
Authors	Nam, Y.W.,Zhang, M. (deposition date: 2017-08-07, release date: 2018-08-08, Last modification date: 2024-03-13)
Primary citation	Nam, Y.W.,Baskoylu, S.N.,Gazgalis, D.,Orfali, R.,Cui, M.,Hart, A.C.,Zhang, M. A V-to-F substitution in SK2 channels causes Ca2+hypersensitivity and improves locomotion in a C. elegans ALS model. Sci Rep, 8:10749-10749, 2018 Cited by PubMed: 30013223 DOI: 10.1038/s41598-018-28783-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation