6AK3

Crystal structure of the human prostaglandin E receptor EP3 bound to prostaglandin E2

Summary for 6AK3

Entry DOI	10.2210/pdb6ak3/pdb
Descriptor	Prostaglandin E2 receptor EP3 subtype,Soluble cytochrome b562, (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (3 entities in total)
Functional Keywords	gpcr, lipid, signaling protein, prostanoid receptor, membrane protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	94314.50
Authors	Morimoto, K.,Suno, R.,Iwata, S.,Kobayashi, T. (deposition date: 2018-08-29, release date: 2018-12-05, Last modification date: 2023-09-06)
Primary citation	Morimoto, K.,Suno, R.,Hotta, Y.,Yamashita, K.,Hirata, K.,Yamamoto, M.,Narumiya, S.,Iwata, S.,Kobayashi, T. Crystal structure of the endogenous agonist-bound prostanoid receptor EP3. Nat. Chem. Biol., 15:8-10, 2019 Cited by PubMed: 30510192 DOI: 10.1038/s41589-018-0171-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation