SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborDownloads

6COX

CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2) COMPLEXED WITH A SELECTIVE INHIBITOR, SC-558 IN I222 SPACE GROUP

Summary for 6COX
DescriptorCYCLOOXYGENASE-2, PROTOPORPHYRIN IX CONTAINING FE, 1-PHENYLSULFONAMIDE-3-TRIFLUOROMETHYL-5-PARABROMOPHENYLPYRAZOLE
Functional KeywordsPEROXIDASE, DIOXYGENASE, CYCLOOXYGENASE, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, INFLAMMATION, ARTHRITIS, PROSTAGLANDIN, PROSTAGLANDIN SYNTHASE, OXIDOREDUCTASE
Biological sourceMus musculus (house mouse)
Organ source
Total number of polymer chains2
Total molecular weight138091.49
Authors
Kurumbail, R.,Stallings, W. (deposition date: 1996-12-18, release date: 1997-12-24, modification date: 2011-07-13)
Primary citation
Kurumbail, R.G., Stevens, A.M., Gierse, J.K., McDonald, J.J., Stegeman, R.A., Pak, J.Y., Gildehaus, D., Miyashiro, J.M., Penning, T.D., Seibert, K., Isakson, P.C., Stallings, W.C.
Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents.
Nature, 384:644-648, 1996
PubMed: 8967954
DOI: 10.1038/384644a0
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
More Asymmetric unit images
no rotation
rotated about x axis by 90°
rotated about y axis by 90°

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